CPT code 96405: Intralesional chemotherapy, up to seven lesions2026 Medicare rate & RVUs in Virginia

Report 96405 when an antineoplastic drug is administered directly into one to seven lesions, such as in a dermatology or oncology setting.

CMS RVU26DEffective Oct 1, 2026One payment locality30.7K Medicare services in 2024

In Virginia, Medicare pays $83.09 for 96405 in the office and $23.33 when it’s performed in a hospital or facility.

$83.09Office (non-facility)
$23.33Hospital or facility
−1.7%vs the national office rate ($84.50)

Check a contract rate as a % of Medicare · 96405 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 96405 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Virginia
  2. What 96405 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 96405 covers

A physician or other qualified practitioner reports 96405 for administering chemotherapy directly into one or more lesions, with the code covering up to seven lesions. This is a local injection into the lesions, rather than systemic chemotherapy given subcutaneously, intramuscularly, or intravenously. Dermatology and oncology practices commonly provide this service for selected cutaneous lesions; the code represents the administration, not the drug product.

Document the antineoplastic agent, intralesional route, treated sites, and lesion count. Use the code for one through seven lesions; when more than seven are treated, compare the service with 96406. CMS assigns a 0-day global period, so same-day preoperative and postoperative care is included. When multiple procedures are performed in the same session, the highest-valued procedure is paid in full and other procedures are subject to the standard 50% reduction. Modifier 50 is inappropriate. CMS does not pay an assistant at surgery for this service, and co-surgeon and team-surgery billing are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Virginia compares for 96405

Across 109 of 109 payment localities, the office rate for 96405 runs from $74.69 in Arkansas to $115.18 in San Benito County, CA. Virginia pays $83.09. The RVUs are the same everywhere; the geographic indexes change the dollars.

96405 in Virginia vs other payment areas
  1. Virginia · this page$83.09
  2. Los Angeles, CA · California$96.98+$13.89
  3. Washington, DC area · District of Columbia$97.33+$14.24
  4. Miami, FL · Florida$88.75+$5.66
  5. Chicago, IL · Illinois$86.25+$3.16
  6. Manhattan, NY · New York$96.92+$13.83
  7. Alaska · Alaska$97.04+$13.95

Other areas in Virginia first, then benchmark localities. Bars start at $0.

Every other payment area

96405 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$75.80$22.61
ArkansasArkansas$74.69$22.48
ArizonaArizona$82.31$23.40
Bakersfield, CACalifornia$90.79$24.17
Chico, CACalifornia$90.68$24.06
El Centro, CACalifornia$90.69$24.06
Fresno, CACalifornia$90.68$24.06
Hanford, CACalifornia$90.68$24.06

96405 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$74.69

$102.93

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
96405 office rate range by state
State / territoryOffice rate rangeLocalities
AK$97.041
AL$75.801
AR$74.691
AZ$82.311
CA$90.68–$115.1829
CO$88.731
CT$90.151
DC$97.331
DE$83.701
FL$82.10–$88.753
GA$77.55–$85.822
GU$93.141
HI$93.141
IA$78.281
ID$78.691
IL$79.31–$87.194
IN$79.161
KS$77.661
KY$77.081
LA$76.86–$80.742
MA$88.08–$97.942
MD$85.39–$97.333
ME$78.83–$83.542
MI$78.88–$82.882
MN$85.721
MO$75.35–$81.333
MS$75.051
MT$84.501
NC$79.711
ND$83.911
NE$78.791
NH$87.091
NJ$91.38–$96.252
NM$79.221
NV$84.401
NY$80.90–$98.975
OH$78.761
OK$77.201
OR$83.94–$91.872
PA$79.03–$87.722
PR$85.221
RI$86.911
SC$79.331
SD$83.841
TN$78.021
TX$78.48–$88.268
UT$80.431
VA$83.09–$97.332
VI$85.221
VT$83.351
WA$88.00–$100.202
WI$81.031
WV$76.271
WY$84.241

See 96405 in every payment locality

How the 96405 rate is calculated

Each of 96405’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 96405

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.52

0.52 RVUs× 1.000 GPCI

Practice expense1.98

1.98 RVUs× 1.000 GPCI

Malpractice0.03

0.03 RVUs× 1.000 GPCI

Adjusted RVUs

2.5300

Conversion factor

$33.4009

Medicare rate

$84.50

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Virginia inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

12,797

Code
96405
Physician work
0.52
Practice expense
1.98
Malpractice
0.03

GPCI2026.csv

106

Locality
Virginia
Physician work
1.000
Practice expense
0.983
Malpractice
0.706
Office calculation for 96405 in Virginia
ComponentRVULocality factorAdjusted
Physician work0.52× 1.0000.5200
Practice expense1.98× 0.9831.9463
Malpractice0.03× 0.7060.0212
Total RVUs2.4875
Conversion factor× 33.4009

Office rate, Virginia$83.09

Office: (0.52 × 1 + 1.98 × 0.983 + 0.03 × 0.706) × $33.4009 = $83.09

Facility: (0.52 × 1 + 0.16 × 0.983 + 0.03 × 0.706) × $33.4009 = $23.33

Open 96405 in the RVU calculator

Payment rules and modifiers for 96405

The CMS indicators that decide how 96405 is paid alongside other services.

CMS payment indicators · 96405

Intralesional chemotherapy, up to seven lesions

RuleCMS valueWhat it means
Global period000Same-day global: pre- and post-op care on the day of the procedure is included.
Multiple procedures2Standard reduction: highest-valued procedure at 100%, others at 50%.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

What modifiers do to the payment

Modifier 51 · payment effect

With and without the modifier

96405 without 51 · national office

$84.50

Intralesional chemotherapy, up to seven lesions

96405-51 · Second procedure: 50%

$42.25

When this isn’t the highest-valued procedure in the session, Medicare pays 50% of its fee schedule amount (the highest is paid at 100%).

When to use modifier 51

How 96405 has changed in Virginia

96405 · Office / nonfacility

$83.09

Effective 2026-10-01

The base rate is $4.71 higher than on 2025-10-01, moving from $78.38 to $83.09 (6.0%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $78.38changed to$83.09

    • Conversion factor 32.3465 changed to 33.4009
    • Practice expense RVU 1.91 changed to 1.98
    • Work GPCI 1.002 changed to 1.000
    • Practice expense GPCI 0.984 changed to 0.983
    • Malpractice GPCI 0.755 changed to 0.706

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $81.64changed to$78.38

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 1.94 changed to 1.91

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $80.31changed to$81.64

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $84.16changed to$80.31

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 1.95 changed to 1.94
    • Malpractice RVU 0.04 changed to 0.03
    • Work GPCI 1.000 changed to 1.002
    • Practice expense GPCI 0.990 changed to 0.984
    • Malpractice GPCI 0.826 changed to 0.755
  5. January 1, 2023

    RVU23A

    $86.38changed to$84.16

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense GPCI 0.995 changed to 0.990
    • Malpractice GPCI 0.897 changed to 0.826

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $87.10changed to$86.38

    • Conversion factor 34.8931 changed to 34.6062

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $84.12changed to$87.10

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 1.80 changed to 1.95
    • Malpractice RVU 0.03 changed to 0.04
    • Practice expense GPCI 0.991 changed to 0.995
    • Malpractice GPCI 0.903 changed to 0.897

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $82.26changed to$84.12

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 1.76 changed to 1.80
    • Practice expense GPCI 0.986 changed to 0.991
    • Malpractice GPCI 0.908 changed to 0.903

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $81.46changed to$82.26

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 1.74 changed to 1.76

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $81.81changed to$81.46

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 1.76 changed to 1.74
    • Practice expense GPCI 0.985 changed to 0.986
    • Malpractice GPCI 0.866 changed to 0.908

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $81.45changed to$81.81

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense GPCI 0.983 changed to 0.985
    • Malpractice GPCI 0.824 changed to 0.866

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $81.45changed to$81.45

    • Conversion factor 35.9335 changed to 35.8043
    • Malpractice RVU 0.02 changed to 0.03

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $81.04changed to$81.45

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $79.85changed to$81.04

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 1.72 changed to 1.76
    • Malpractice RVU 0.03 changed to 0.02
    • Practice expense GPCI 0.980 changed to 0.983
    • Malpractice GPCI 0.778 changed to 0.824

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $82.26changed to$79.85

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 1.92 changed to 1.72
    • Practice expense GPCI 0.977 changed to 0.980
    • Malpractice GPCI 0.731 changed to 0.778

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $82.26

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$83.09$23.33RVU26D
2026-07-01$83.09$23.33RVU26C
2026-04-01$83.09$23.33RVU26B
2026-01-01$83.09$23.33RVU26A
2025-10-01$78.38$27.45RVU25D
2025-07-01$78.38$27.45RVU25C
2025-04-01$78.38$27.45RVU25B
2025-01-01$78.38$27.45RVU25A
2024-10-01$81.64$27.92RVU24D
2024-07-01$81.64$27.92RVU24C
2024-04-01$81.64$27.92RVU24B
2024-03-09$81.64$27.92RVU24AR
2024-01-01$80.31$27.47RVU24A
2023-10-01$84.16$28.81RVU23D
2023-07-01$84.16$28.81RVU23C
2023-04-01$84.16$28.81RVU23B
2023-01-01$84.16$28.81RVU23A
2022-10-01$86.38$28.88RVU22D
2022-07-01$86.38$28.88RVU22C
2022-04-01$86.38$28.88RVU22B
2022-01-01$86.38$28.88RVU22A
2021-10-01$87.10$29.12RVU21D
2021-07-01$87.10$29.12RVU21C
2021-04-01$87.10$29.12RVU21B
2021-01-01$87.10$29.12RVU21A
2020-10-01$84.12$30.12RVU20D
2020-07-01$84.12$30.12RVU20C
2020-04-01$84.12$30.12RVU20B
2020-01-01$84.12$30.12RVU20A
2019-10-01$82.26$30.03RVU19D
2019-07-01$82.26$30.03RVU19C
2019-04-01$82.26$30.03RVU19B
2019-01-01$82.26$30.03RVU19A
2018-10-01$81.46$30.35RVU18D
2018-07-01$81.46$30.35RVU18C
2018-04-01$81.46$30.35RVU18B
2018-01-01$81.46$30.35RVU18AR1
2017-10-01$81.81$30.55RVU17D
2017-07-01$81.81$30.55RVU17C
2017-04-01$81.81$30.55RVU17B
2017-01-01$81.81$30.55RVU17A
2016-10-01$81.45$30.06RVU16D
2016-07-01$81.45$30.06RVU16C
2016-04-01$81.45$30.06RVU16B
2016-01-01$81.45$30.06RVU16A
2015-10-01$81.45$29.87RVU15D
2015-07-01$81.45$29.87RVU15C
2015-04-01$81.04$29.73RVU15B
2015-01-01$81.04$29.73RVU15A
2014-10-01$79.85$30.00RVU14D
2014-07-01$79.85$30.00RVU14C
2014-04-01$79.85$30.00RVU14B
2014-01-01$79.85$30.00RVU14A
2013-10-01$82.26$29.41RVU13D
2013-07-01$82.26$29.41RVU13C
2013-04-01$82.26$29.41RVU13B
2013-01-01$82.26$29.41RVU13AR

Price 96405 for an earlier date of service

Where the Virginia rate applies

Virginia is a Medicare payment area, not a city. Our Census mapping connects it to 628 cities and communities in Virginia. Some span more than one payment area; confirm with the service ZIP.

  • Abbs Valley
  • Abingdon
  • Accomac
  • Adwolf
  • Afton
  • Alberta
  • Aldie
  • Allison Gap

Browse all communities in Virginia

96405 billing questions

How many lesions can be reported with 96405?

96405 covers administration into one through seven lesions. For treatment of more than seven lesions, compare the service with 96406 rather than reporting 96405 for every lesion.

How is 96405 different from 11900?

96405 is for intralesional chemotherapy. Code 11900 is for intralesional injection of a substance other than chemotherapy, for up to seven lesions.

Is the chemotherapy drug included in 96405?

No. The code represents administration; report a separately payable drug product under its applicable code when the practice supplies it and documentation supports separate reporting.

Should modifier 50 be used when lesions are on both sides?

No. CMS identifies bilateral adjustment as inappropriate for 96405. Report the service based on the number of treated lesions, not as a bilateral procedure.

What documentation supports 96405?

Record the drug, intralesional route, lesion locations, and number of lesions treated. The count supports choosing 96405 for up to seven lesions or 96406 for more than seven.

How does CMS handle other procedures performed in the same session?

The highest-valued procedure is paid in full, and other procedures in the same session are subject to the standard multiple procedure reduction. CMS does not pay an assistant at surgery for 96405.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 96405PPRRVU2026_Oct_nonQPP.csv, line 12,797 (RVU26D)
Geographic factors for VirginiaGPCI2026.csv, line 106 (RVU26D)

Open CMS sourceHow we calculate rates

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