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CPT code 96450: Chemotherapy administration, into central nervous system2026 Medicare rate & RVUs in Indiana

Report this service when chemotherapy is delivered into the central nervous system, such as intrathecally, including access by spinal puncture.

CMS RVU26DEffective Oct 1, 2026One payment locality8.1K Medicare services in 2024

In Indiana, Medicare pays $150.91 for 96450 in the office and $63.28 when it’s performed in a hospital or facility.

$150.91Office (non-facility)
$63.28Hospital or facility
−6.3%vs the national office rate ($160.99)

Check a contract rate as a % of Medicare · 96450 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 96450 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Indiana
  2. What 96450 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 96450 covers

This service covers delivery of chemotherapy into the central nervous system, most commonly by an intrathecal route through a lumbar puncture. It may be performed in an oncology or hematology clinic, hospital outpatient department, or other setting where CNS-directed treatment is administered. Patients may receive it for conditions such as CNS leukemia or leptomeningeal disease. Administration through an intraventricular access device is also a CNS route.

Select this code based on the route of drug delivery, not the drug name or the diagnosis alone. Documentation should identify the medication, CNS route, access method, and completed administration. The spinal puncture used to access the treatment site is included in this service. The chemotherapy drug itself is separate from the administration service when separately reportable. CMS assigns a 0-day global period, so same-day preoperative and postoperative care is included. Modifier 50 is inappropriate. Assistant-at-surgery payment requires medical-necessity documentation; co-surgeons and team surgery are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Indiana compares for 96450

Across 109 of 109 payment localities, the office rate for 96450 runs from $143.89 in Arkansas to $210.95 in San Benito County, CA. Indiana pays $150.91. The RVUs are the same everywhere; the geographic indexes change the dollars.

96450 in Indiana vs other payment areas
  1. Indiana · this page$150.91
  2. Los Angeles, CA · California$180.77+$29.86
  3. Washington, DC area · District of Columbia$183.01+$32.10
  4. Miami, FL · Florida$172.46+$21.55
  5. Chicago, IL · Illinois$167.93+$17.02
  6. Manhattan, NY · New York$184.05+$33.14
  7. Alaska · Alaska$191.28+$40.37

Other areas in Indiana first, then benchmark localities. Bars start at $0.

Every other payment area

96450 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$145.81$63.10
ArkansasArkansas$143.89$62.69
ArizonaArizona$157.06$65.46
Bakersfield, CACalifornia$170.24$66.64
Chico, CACalifornia$169.79$66.19
El Centro, CACalifornia$169.82$66.22
Fresno, CACalifornia$169.79$66.19
Hanford, CACalifornia$169.79$66.19

96450 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$143.89

$191.28

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
96450 office rate range by state
State / territoryOffice rate rangeLocalities
AK$191.281
AL$145.811
AR$143.891
AZ$157.061
CA$169.79–$210.9529
CO$167.321
CT$171.101
DC$183.011
DE$159.511
FL$158.72–$172.463
GA$150.53–$163.772
GU$173.441
HI$173.441
IA$149.231
ID$150.111
IL$154.47–$167.934
IN$150.911
KS$148.571
KY$148.921
LA$148.70–$155.422
MA$166.44–$182.982
MD$162.38–$183.013
ME$150.81–$158.322
MI$152.44–$160.522
MN$160.751
MO$146.35–$155.953
MS$145.151
MT$160.981
NC$152.251
ND$158.211
NE$149.981
NH$164.721
NJ$173.17–$181.362
NM$153.201
NV$160.321
NY$154.34–$188.165
OH$151.881
OK$148.691
OR$159.18–$172.292
PA$152.11–$167.132
PR$162.081
RI$164.931
SC$152.291
SD$157.891
TN$149.251
TX$151.19–$166.668
UT$154.201
VA$157.83–$183.012
VI$162.081
VT$157.631
WA$166.12–$186.582
WI$153.341
WV$149.221
WY$159.781

See 96450 in every payment locality

How the 96450 rate is calculated

Each of 96450’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 96450

RVUs × geographic indexes × conversion factor

Office or facility?

Work1.53

1.53 RVUs× 1.000 GPCI

Practice expense3.15

3.15 RVUs× 1.000 GPCI

Malpractice0.14

0.14 RVUs× 1.000 GPCI

Adjusted RVUs

4.8200

Conversion factor

$33.4009

Medicare rate

$160.99

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Indiana inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

12,811

Code
96450
Physician work
1.53
Practice expense
3.15
Malpractice
0.14

GPCI2026.csv

52

Locality
Indiana
Physician work
1.000
Practice expense
0.927
Malpractice
0.486
Office calculation for 96450 in Indiana
ComponentRVULocality factorAdjusted
Physician work1.53× 1.0001.5300
Practice expense3.15× 0.9272.9201
Malpractice0.14× 0.4860.0680
Total RVUs4.5181
Conversion factor× 33.4009

Office rate, Indiana$150.91

Office: (1.53 × 1 + 3.15 × 0.927 + 0.14 × 0.486) × $33.4009 = $150.91

Facility: (1.53 × 1 + 0.32 × 0.927 + 0.14 × 0.486) × $33.4009 = $63.28

Open 96450 in the RVU calculator

Payment rules and modifiers for 96450

The CMS indicators that decide how 96450 is paid alongside other services.

CMS payment indicators · 96450

Chemotherapy administration, into central nervous system

RuleCMS valueWhat it means
Global period000Same-day global: pre- and post-op care on the day of the procedure is included.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

Codes related to 96450

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to 96450
CodeHow it relatesOffice range, Indiana
Used instead
96401Chemotherapy injection, subcutaneous or intramuscular, nonhormonalFor chemotherapy delivered subcutaneously or intramuscularly rather than into the CNS.$66.49
96440Pleural chemotherapy, with thoracentesisFor chemotherapy delivered into the pleural cavity rather than the central nervous system.$714.63
96446Chemotherapy administration, peritoneal cavity via catheterFor chemotherapy delivered into the peritoneal cavity rather than the central nervous system.$144.66

How 96450 has changed in Indiana

96450 · Office / nonfacility

$150.91

Effective 2026-10-01

The base rate is $7.21 higher than on 2025-10-01, moving from $143.70 to $150.91 (5.0%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $143.70changed to$150.91

    • Conversion factor 32.3465 changed to 33.4009
    • Practice expense RVU 3.08 changed to 3.15
    • Malpractice RVU 0.15 changed to 0.14
    • Practice expense GPCI 0.922 changed to 0.927
    • Malpractice GPCI 0.485 changed to 0.486

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $150.79changed to$143.70

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 3.18 changed to 3.08
    • Malpractice RVU 0.14 changed to 0.15

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $148.33changed to$150.79

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $154.74changed to$148.33

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 3.26 changed to 3.18
    • Practice expense GPCI 0.911 changed to 0.922
    • Malpractice GPCI 0.475 changed to 0.485

  5. January 1, 2023

    RVU23A

    $159.84changed to$154.74

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 3.37 changed to 3.26
    • Malpractice RVU 0.12 changed to 0.14
    • Practice expense GPCI 0.900 changed to 0.911
    • Malpractice GPCI 0.465 changed to 0.475

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $167.61changed to$159.84

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 3.57 changed to 3.37
    • Malpractice RVU 0.13 changed to 0.12

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $169.69changed to$167.61

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 3.43 changed to 3.57
    • Malpractice RVU 0.12 changed to 0.13
    • Practice expense GPCI 0.910 changed to 0.900
    • Malpractice GPCI 0.422 changed to 0.465

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $172.04changed to$169.69

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 3.48 changed to 3.43
    • Practice expense GPCI 0.919 changed to 0.910
    • Malpractice GPCI 0.379 changed to 0.422

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $173.83changed to$172.04

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 3.54 changed to 3.48

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $171.96changed to$173.83

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 3.48 changed to 3.54
    • Practice expense GPCI 0.920 changed to 0.919
    • Malpractice GPCI 0.498 changed to 0.379

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $172.52changed to$171.96

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 3.49 changed to 3.48
    • Practice expense GPCI 0.921 changed to 0.920
    • Malpractice GPCI 0.617 changed to 0.498

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $172.81changed to$172.52

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 3.48 changed to 3.49

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $171.95changed to$172.81

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $170.85changed to$171.95

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 3.44 changed to 3.48
    • Malpractice RVU 0.11 changed to 0.12
    • Practice expense GPCI 0.922 changed to 0.921
    • Malpractice GPCI 0.615 changed to 0.617

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $169.60changed to$170.85

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 3.67 changed to 3.44
    • Practice expense GPCI 0.923 changed to 0.922
    • Malpractice GPCI 0.613 changed to 0.615

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $169.60

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$150.91$63.28RVU26D
2026-07-01$150.91$63.28RVU26C
2026-04-01$150.91$63.28RVU26B
2026-01-01$150.91$63.28RVU26A
2025-10-01$143.70$70.04RVU25D
2025-07-01$143.70$70.04RVU25C
2025-04-01$143.70$70.04RVU25B
2025-01-01$143.70$70.04RVU25A
2024-10-01$150.79$71.30RVU24D
2024-07-01$150.79$71.30RVU24C
2024-04-01$150.79$71.30RVU24B
2024-03-09$150.79$71.30RVU24AR
2024-01-01$148.33$70.13RVU24A
2023-10-01$154.74$72.62RVU23D
2023-07-01$154.74$72.62RVU23C
2023-04-01$154.74$72.62RVU23B
2023-01-01$154.74$72.62RVU23A
2022-10-01$159.84$73.25RVU22D
2022-07-01$159.84$73.25RVU22C
2022-04-01$159.84$73.25RVU22B
2022-01-01$159.84$73.25RVU22A
2021-10-01$167.61$74.34RVU21D
2021-07-01$167.61$74.34RVU21C
2021-04-01$167.61$74.34RVU21B
2021-01-01$167.61$74.34RVU21A
2020-10-01$169.69$77.08RVU20D
2020-07-01$169.69$77.08RVU20C
2020-04-01$169.69$77.08RVU20B
2020-01-01$169.69$77.08RVU20A
2019-10-01$172.04$77.31RVU19D
2019-07-01$172.04$77.31RVU19C
2019-04-01$172.04$77.31RVU19B
2019-01-01$172.04$77.31RVU19A
2018-10-01$173.83$77.89RVU18D
2018-07-01$173.83$77.89RVU18C
2018-04-01$173.83$77.89RVU18B
2018-01-01$173.83$77.89RVU18AR1
2017-10-01$171.96$78.52RVU17D
2017-07-01$171.96$78.52RVU17C
2017-04-01$171.96$78.52RVU17B
2017-01-01$171.96$78.52RVU17A
2016-10-01$172.52$78.87RVU16D
2016-07-01$172.52$78.87RVU16C
2016-04-01$172.52$78.87RVU16B
2016-01-01$172.52$78.87RVU16A
2015-10-01$172.81$78.82RVU15D
2015-07-01$172.81$78.82RVU15C
2015-04-01$171.95$78.43RVU15B
2015-01-01$171.95$78.43RVU15A
2014-10-01$170.85$78.70RVU14D
2014-07-01$170.85$78.70RVU14C
2014-04-01$170.85$78.70RVU14B
2014-01-01$170.85$78.70RVU14A
2013-10-01$169.60$75.08RVU13D
2013-07-01$169.60$75.08RVU13C
2013-04-01$169.60$75.08RVU13B
2013-01-01$169.60$75.08RVU13AR

Price 96450 for an earlier date of service

Where the Indiana rate applies

Indiana is a Medicare payment area, not a city. Our Census mapping connects it to 974 cities and communities in Indiana. Some span more than one payment area; confirm with the service ZIP.

  • Aberdeen
  • Abington
  • Adams
  • Adams Lake
  • Advance
  • Akron
  • Alamo
  • Albany

Browse all communities in Indiana

96450 billing questions

When should 96450 be selected instead of another chemotherapy administration code?

Use it when chemotherapy is delivered into the central nervous system, such as intrathecally or through an intraventricular access device. Select other administration codes for different routes, such as subcutaneous, intramuscular, or intravenous delivery.

Is the spinal puncture separately reported with 96450?

The puncture used to gain access for the CNS chemotherapy administration is included in this service.

Does 96450 include the chemotherapy drug?

The code represents the administration service, not the drug product. Report the drug separately when it is separately billable and supported by the claim documentation.

Can modifier 50 be used for bilateral CNS administration?

No. CMS identifies bilateral adjustment as inappropriate for this code.

What documentation supports 96450?

Record the medication, the CNS route, the access method, and that administration was completed. CMS assigns a 0-day global period, so same-day preoperative and postoperative care is included.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 96450PPRRVU2026_Oct_nonQPP.csv, line 12,811 (RVU26D)
Geographic factors for IndianaGPCI2026.csv, line 52 (RVU26D)

Open CMS sourceHow we calculate rates

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