HCPCS code J0641: Levoleucovorin injection, per 0.5 mg2026 Medicare rate & RVUs in Texas
Reports injectable levoleucovorin used for methotrexate rescue or with fluorouracil in certain cancer regimens, in 0.5 mg billing units.
CMS doesn’t publish an office rate for J0641 in Texas.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What J0641 covers
Levoleucovorin is the active isomer of folinic acid. Oncology teams administer it by injection, typically intravenously, for rescue after high-dose methotrexate and as part of certain fluorouracil regimens, including treatment of colorectal cancer. The drug is commonly administered in physician offices and hospital outpatient oncology settings. Report this code for levoleucovorin that is not identified by a more specific product code.
CMS assigns this HCPCS Level II drug code physician fee schedule status E, meaning it is excluded from the physician fee schedule. When Medicare covers the drug, payment follows another method; CMS classifies it as a Part B drug generally priced using its quarterly Average Sales Price files. Special Medicare coverage instructions apply. Each unit represents 0.5 mg of levoleucovorin, so units reflect the administered dose in 0.5 mg increments.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where J0641 pays more and less in Texas
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
8 of 8 payment localities
| Payment locality | Office | Facility |
|---|---|---|
| Austin, TX | Unavailable | Unavailable |
| Beaumont, TX | Unavailable | Unavailable |
| Brazoria, TX | Unavailable | Unavailable |
| Dallas, TX | Unavailable | Unavailable |
| Fort Worth, TX | Unavailable | Unavailable |
| Galveston, TX | Unavailable | Unavailable |
| Houston, TX | Unavailable | Unavailable |
| Rest of Texas | Unavailable | Unavailable |
How the J0641 rate is calculated
Each of J0641’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · J0641
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense0.00
0.00 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
0.0000
Conversion factor
$33.4009
Medicare rate
$0.00
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for J0641
J0641 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.
Place of service · J0641
Which rate does Medicare pay?
The POS code on the claim line (CMS-1500 box 24B).
POS 11 · non-facility rate · national
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J0641 isn’t priced in this setting.
J0641 compared with similar codes
Compare codes · National
4 codes, side by side
How to choose
- J0642Levoleucovorin injectionKhapzory, per 0.5 mg
- J0642 identifies Khapzory, a specific levoleucovorin product. J0641 is for levoleucovorin not otherwise specified.
- J0640Leucovorin injectionPer 50 mg
- J0640 identifies leucovorin calcium injection. J0641 identifies levoleucovorin, so choose according to the drug administered.
- J0643Leucovorin injectionPer 1 mg
- J0643 identifies leucovorin calcium injection in 1 mg units; J0641 is levoleucovorin in 0.5 mg units.
J0641 billing questions
How many units should be reported?
One unit represents 0.5 mg of levoleucovorin. Report units based on the administered dose in 0.5 mg increments.
When should J0641 be used instead of J0642?
J0641 is for levoleucovorin not otherwise specified. Use J0642 when the administered product is Khapzory.
How does J0641 differ from leucovorin calcium codes?
J0641 identifies levoleucovorin, the active isomer. J0640 and J0643 identify leucovorin calcium; select the code that matches the drug administered.
Is J0641 paid under the physician fee schedule?
No. CMS assigns status E, excluding it from the physician fee schedule. When Medicare covers the drug, it generally uses the Part B drug pricing method based on quarterly ASP files.
Is levoleucovorin commonly reported with fluorouracil?
Yes. The drugs may be administered together in certain cancer regimens, including colorectal cancer treatment; J9190 identifies injectable fluorouracil.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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