FeeBase
Log inGet started
Menu

HCPCS code J0640: Leucovorin injection, per 50 mg2026 Medicare rate & RVUs

Leucovorin calcium injection is used for methotrexate rescue and with fluorouracil; Medicare does not accept J0640 for reporting.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare rate · J0640

Leucovorin injection, per 50 mg

Office or facility?

Work RVUs
0
Total RVUs
0.00
Global days
XXX

National rate · 2026

—

Not priced in the facility setting.

See every locality for J0640 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What J0640 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What J0640 covers

Leucovorin calcium, a form of folinic acid, is given by injection, usually intravenously or intramuscularly. Oncology teams use it to reduce the effects of methotrexate, and some chemotherapy regimens pair it with fluorouracil. The drug may be administered as part of cancer treatment or methotrexate rescue.

J0640 has Medicare physician fee schedule status I, meaning it is not a valid Medicare reporting code and Medicare uses a different code for the service. Its unit definition is 50 mg of leucovorin calcium, but that unit basis does not make J0640 valid for Medicare claims. The HCPCS pricing classification is Part B drug; when covered, Medicare generally pays from CMS quarterly Average Sales Price drug pricing files. Special Medicare coverage instructions apply.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where J0640 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

J0640 office and facility rates by payment locality
Payment localityOfficeFacility
AlabamaUnavailableUnavailable
AlaskaUnavailableUnavailable
ArizonaUnavailableUnavailable
ArkansasUnavailableUnavailable
Atlanta, GAUnavailableUnavailable
Austin, TXUnavailableUnavailable
Bakersfield, CAUnavailableUnavailable
Baltimore area, MDUnavailableUnavailable
Beaumont, TXUnavailableUnavailable
Brazoria, TXUnavailableUnavailable

J0640 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

View every state and territory as a table
J0640 office rate range by state
State / territoryOffice rate rangeLocalities
AKNo published base rate1
ALNo published base rate1
ARNo published base rate1
AZNo published base rate1
CANo published base rate29
CONo published base rate1
CTNo published base rate1
DCNo published base rate1
DENo published base rate1
FLNo published base rate3
GANo published base rate2
GUNo published base rate1
HINo published base rate1
IANo published base rate1
IDNo published base rate1
ILNo published base rate4
INNo published base rate1
KSNo published base rate1
KYNo published base rate1
LANo published base rate2
MANo published base rate2
MDNo published base rate3
MENo published base rate2
MINo published base rate2
MNNo published base rate1
MONo published base rate3
MSNo published base rate1
MTNo published base rate1
NCNo published base rate1
NDNo published base rate1
NENo published base rate1
NHNo published base rate1
NJNo published base rate2
NMNo published base rate1
NVNo published base rate1
NYNo published base rate5
OHNo published base rate1
OKNo published base rate1
ORNo published base rate2
PANo published base rate2
PRNo published base rate1
RINo published base rate1
SCNo published base rate1
SDNo published base rate1
TNNo published base rate1
TXNo published base rate8
UTNo published base rate1
VANo published base rate2
VINo published base rate1
VTNo published base rate1
WANo published base rate2
WINo published base rate1
WVNo published base rate1
WYNo published base rate1

How the J0640 rate is calculated

Each of J0640’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · J0640

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense0.00

0.00 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

0.0000

Conversion factor

$33.4009

Medicare rate

$0.00

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for J0640

J0640 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.

Place of service · J0640

Which rate does Medicare pay?

The POS code on the claim line (CMS-1500 box 24B).

POS 11 · non-facility rate · national

—

J0640 isn’t priced in this setting.

J0640 compared with similar codes

Compare codes · National

4 codes, side by side

Office or facility?

  • J0640

    Leucovorin injection, per 50 mg0 wRVU

    Not priced

  • J0643

    Leucovorin injection, per 1 mg0 wRVU

    Not priced

  • J0641

    Levoleucovorin injection, per 0.5 mg0 wRVU

    Not priced

  • J0644

    Avyxa leucovorin, per 1 mg0 wRVU

    Not priced

How to choose

J0643Leucovorin injectionPer 1 mg
J0643 identifies leucovorin calcium in 1 mg units; J0640 has a 50 mg unit basis and is not valid for Medicare reporting.
J0641Levoleucovorin injectionPer 0.5 mg
J0641 is for levoleucovorin, not leucovorin calcium. Choose based on the drug administered rather than treating the codes as interchangeable.
J0644Avyxa leucovorinPer 1 mg
J0644 identifies product-specific Avyxa leucovorin calcium. J0640 has a 50 mg unit basis and is not valid for Medicare reporting.

Codes related to J0640

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to J0640
CodeHow it relatesNational office range
Used instead
J0643Leucovorin injection, per 1 mgIdentifies injectable leucovorin calcium with a 1 mg unit basis.No office rate
J0641Levoleucovorin injection, per 0.5 mgIdentifies levoleucovorin, a distinct drug used in related treatment settings.No office rate
J0644Avyxa leucovorin, per 1 mgIdentifies the product-specific Avyxa leucovorin calcium injection.No office rate

J0640 billing questions

Can J0640 be submitted to Medicare for leucovorin calcium?

No. J0640 has Medicare status I and is not valid for Medicare reporting; Medicare uses a different code for this service.

How does J0640 differ from J0643?

Both identify injectable leucovorin calcium, but J0640 has a 50 mg unit basis and J0643 has a 1 mg unit basis.

What does one J0640 unit represent?

One unit represents 50 mg of leucovorin calcium. J0640 is not valid for Medicare reporting.

How does J0641 differ from J0640?

J0641 identifies levoleucovorin, a distinct drug. Select the code for the drug administered rather than treating the two drugs as interchangeable.

How does Medicare classify leucovorin calcium for payment?

The HCPCS pricing classification is Part B drug; when covered, Medicare generally pays from CMS quarterly ASP drug pricing files. J0640 itself is not valid for Medicare reporting, and special coverage instructions apply.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates

Did this answer your question about what J0640 pays?

Tell us what you were actually trying to work out. We’ll answer you directly, or build the page that does.

Fee sheets · Coming soon

Put J0640 and the rest of your codes on one sheet

Your codes at your locality, with payer contracts beside Medicare.

Join the waitlist