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HCPCS code J0643: Leucovorin injection, per 1 mg2026 Medicare rate & RVUs

Injectable leucovorin calcium is reported in 1 mg units for methotrexate rescue or as part of certain fluorouracil cancer regimens.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare rate · J0643

Leucovorin injection, per 1 mg

Office or facility?

Work RVUs
0
Total RVUs
0.00
Global days
XXX

National rate · 2026

—

Not priced in the facility setting.

See every locality for J0643 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What J0643 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What J0643 covers

J0643 identifies injectable leucovorin calcium not otherwise specified. Leucovorin is used as rescue after high-dose methotrexate and alongside fluorouracil in cancer treatment. Oncology clinicians administer it by injection, commonly in outpatient oncology offices and infusion centers. Choose the appropriate leucovorin code for the product supplied; J0643 is the not-otherwise-specified option.

One unit represents 1 mg of leucovorin calcium, so reported units match the administered milligram dose. CMS assigns physician fee schedule status E, excluding J0643 from the physician fee schedule by regulation. When Medicare covers the drug, payment is under another method; as a Part B drug, it is generally priced using CMS quarterly Average Sales Price drug pricing files. Special Medicare coverage instructions apply.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where J0643 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

J0643 office and facility rates by payment locality
Payment localityOfficeFacility
AlabamaUnavailableUnavailable
AlaskaUnavailableUnavailable
ArizonaUnavailableUnavailable
ArkansasUnavailableUnavailable
Atlanta, GAUnavailableUnavailable
Austin, TXUnavailableUnavailable
Bakersfield, CAUnavailableUnavailable
Baltimore area, MDUnavailableUnavailable
Beaumont, TXUnavailableUnavailable
Brazoria, TXUnavailableUnavailable

J0643 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

View every state and territory as a table
J0643 office rate range by state
State / territoryOffice rate rangeLocalities
AKNo published base rate1
ALNo published base rate1
ARNo published base rate1
AZNo published base rate1
CANo published base rate29
CONo published base rate1
CTNo published base rate1
DCNo published base rate1
DENo published base rate1
FLNo published base rate3
GANo published base rate2
GUNo published base rate1
HINo published base rate1
IANo published base rate1
IDNo published base rate1
ILNo published base rate4
INNo published base rate1
KSNo published base rate1
KYNo published base rate1
LANo published base rate2
MANo published base rate2
MDNo published base rate3
MENo published base rate2
MINo published base rate2
MNNo published base rate1
MONo published base rate3
MSNo published base rate1
MTNo published base rate1
NCNo published base rate1
NDNo published base rate1
NENo published base rate1
NHNo published base rate1
NJNo published base rate2
NMNo published base rate1
NVNo published base rate1
NYNo published base rate5
OHNo published base rate1
OKNo published base rate1
ORNo published base rate2
PANo published base rate2
PRNo published base rate1
RINo published base rate1
SCNo published base rate1
SDNo published base rate1
TNNo published base rate1
TXNo published base rate8
UTNo published base rate1
VANo published base rate2
VINo published base rate1
VTNo published base rate1
WANo published base rate2
WINo published base rate1
WVNo published base rate1
WYNo published base rate1

How the J0643 rate is calculated

Each of J0643’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · J0643

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense0.00

0.00 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

0.0000

Conversion factor

$33.4009

Medicare rate

$0.00

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for J0643

J0643 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.

Place of service · J0643

Which rate does Medicare pay?

The POS code on the claim line (CMS-1500 box 24B).

POS 11 · non-facility rate · national

—

J0643 isn’t priced in this setting.

J0643 compared with similar codes

Compare codes · National

5 codes, side by side

Office or facility?

  • J0643

    Leucovorin injection, per 1 mg0 wRVU

    Not priced

  • J0640

    Leucovorin injection, per 50 mg0 wRVU

    Not priced

  • J0644

    Avyxa leucovorin, per 1 mg0 wRVU

    Not priced

  • J0641

    Levoleucovorin injection, per 0.5 mg0 wRVU

    Not priced

  • J0642

    Levoleucovorin injection, khapzory, per 0.5 mg0 wRVU

    Not priced

How to choose

J0640Leucovorin injectionPer 50 mg
J0640 also describes leucovorin calcium injection. J0643 specifies a 1 mg unit; choose according to the applicable product code and descriptor.
J0644Avyxa leucovorinPer 1 mg
J0644 identifies leucovorin calcium as the Avyxa product. J0643 is the not-otherwise-specified leucovorin calcium code.
J0641Levoleucovorin injectionPer 0.5 mg
J0641 is for levoleucovorin, not leucovorin calcium, and its billing unit is 0.5 mg.
J0642Levoleucovorin injectionKhapzory, per 0.5 mg
J0642 identifies the Khapzory levoleucovorin product in 0.5 mg units; J0643 identifies leucovorin calcium in 1 mg units.

Codes related to J0643

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to J0643
CodeHow it relatesNational office range
Same family
J0640Leucovorin injection, per 50 mgAnother HCPCS code for leucovorin calcium injection.No office rate
J0644Avyxa leucovorin, per 1 mgIdentifies the Avyxa leucovorin calcium product.No office rate
Used instead
J0641Levoleucovorin injection, per 0.5 mgIdentifies levoleucovorin, a different injectable used in similar treatment settings.No office rate
J0642Levoleucovorin injection, khapzory, per 0.5 mgIdentifies the Khapzory levoleucovorin product rather than leucovorin calcium.No office rate

J0643 billing questions

What does one J0643 unit represent?

One unit represents 1 mg of leucovorin calcium. Report units to match the administered dose in milligrams.

How is J0643 different from J0640?

Both codes identify leucovorin calcium injection. J0643 specifies a 1 mg unit; select the code that matches the product and applicable HCPCS descriptor.

When should J0643 be distinguished from J0644?

J0643 is the not-otherwise-specified leucovorin calcium code. J0644 identifies the Avyxa product.

Is J0643 the code for levoleucovorin?

No. J0643 is for leucovorin calcium. J0641 and J0642 identify levoleucovorin products.

How does Medicare treat J0643?

Its physician fee schedule status is E, so it is excluded from the physician fee schedule. When covered, it is paid under another method; as a Part B drug, it is generally priced using CMS quarterly ASP drug pricing files. Special Medicare coverage instructions apply.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates

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