HCPCS code J3299: Xipere injection, per 1 mg2026 Medicare rate & RVUs

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What J3299 covers

Xipere is a triamcinolone acetonide suspension administered into the suprachoroidal space of the eye. Ophthalmologists, often retina specialists, use it to treat macular edema associated with uveitis. The drug is supplied for suprachoroidal use, a route distinct from intravitreal injection. Its administration is commonly reported with CPT 67516, the procedure code for suprachoroidal drug injection.

J3299 represents 1 mg of Xipere; the labeled 4 mg dose is reported as 4 units. CMS assigns this code physician fee schedule status E, meaning it is excluded from the physician fee schedule. When Medicare covers the drug, it is a Part B drug generally priced through CMS quarterly ASP drug pricing files. Coverage is left to the Medicare contractor's judgment, and a covered item is paid under another payment method rather than the physician fee schedule.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where J3299 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

J3299 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the J3299 rate is calculated

Each of J3299’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for J3299

J3299 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.

J3299 compared with similar codes

How to choose

J3300Triamcinolone injectionPreservative-free, per 1 mg

J3300 identifies preservative-free triamcinolone by the milligram for intravitreal use. J3299 is specific to Xipere for suprachoroidal use.

J3301Triamcinolone injectionPer 10 mg

J3301 reports triamcinolone acetonide not otherwise specified in 10 mg units. J3299 identifies the specific Xipere product in 1 mg units.

67516Eye injectionSuprachoroidal route

CPT 67516 reports the suprachoroidal injection procedure; J3299 reports the Xipere drug quantity administered.

67028Intravitreal injectionMedication delivered into vitreous cavity

CPT 67028 is for intravitreal injection. CPT 67516 is the procedure code associated with suprachoroidal delivery of Xipere.

Codes related to J3299

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates