HCPCS code Q4101: Skin substitute, apligraf, per square centimeter2026 Medicare rate & RVUs

Medicare pays $127.26 for Q4101 nationally in the office. Local office rates run $109.31–$183.51.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What Q4101 covers

Q4101 represents Apligraf, a living skin substitute used to support healing of chronic wounds such as venous leg ulcers and diabetic foot ulcers. Wound-care physicians, surgeons, podiatrists, and other clinicians may apply it in outpatient wound clinics or other settings where these wounds are treated. The code represents the product, not the clinician’s application service.

Report the quantity based on the square centimeters of Apligraf supplied, and document the wound, product used, and amount applied. Q4101 is an add-on code: report it only with a primary application procedure, and its payment falls within that procedure’s global period. CMS assigns no physician work RVUs and assigns practice-expense RVUs. CMS classifies Q4101 as technical-component-only; a separate code covers interpretation.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4101 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

Q4101 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the Q4101 rate is calculated

Each of Q4101’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for Q4101

The CMS indicators that decide how Q4101 is paid alongside other services.

Q4101 compared with similar codes

How to choose

15271Skin substitute graftFirst 25 cm², trunk/limbs

15271 reports the application procedure for qualifying trunk and extremity wounds; Q4101 reports the Apligraf product used with that procedure.

15275Skin substituteFace and other specified sites

15275 reports the application procedure for qualifying wounds at specified sites such as the head, neck, hands, feet, or genitalia; Q4101 reports the product.

Q4102Wound matrixOasis wound matrix

Q4102 identifies Oasis wound matrix, not Apligraf. Select the product code that matches the skin substitute supplied.

Codes related to Q4101

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates