HCPCS code Q4101: Skin substitute, apligraf, per square centimeter2026 Medicare rate & RVUs in Mississippi

Q4101 reports Apligraf supplied for wound treatment, measured by area and billed with the procedure used to apply the product.

CMS RVU26DEffective Oct 1, 2026One payment locality

In Mississippi, Medicare pays $109.57 for Q4101 in the office.

$109.57Office (non-facility)

Not available in this settingHospital or facility

−13.9%vs the national office rate ($127.26)

Check a contract rate as a % of Medicare · Q4101 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

On this page 11 sections

Rate in Mississippi
What Q4101 covers
Compared with other areas
Rate map
How it’s calculated
Payment rules
Related codes
Rate history
Where it applies
Billing questions
Sources

What Q4101 covers

Q4101 represents Apligraf, a living skin substitute used to support healing of chronic wounds such as venous leg ulcers and diabetic foot ulcers. Wound-care physicians, surgeons, podiatrists, and other clinicians may apply it in outpatient wound clinics or other settings where these wounds are treated. The code represents the product, not the clinician’s application service.

Report the quantity based on the square centimeters of Apligraf supplied, and document the wound, product used, and amount applied. Q4101 is an add-on code: report it only with a primary application procedure, and its payment falls within that procedure’s global period. CMS assigns no physician work RVUs and assigns practice-expense RVUs. CMS classifies Q4101 as technical-component-only; a separate code covers interpretation.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Mississippi compares for Q4101

Across 109 of 109 payment localities, the office rate for Q4101 runs from $109.31 in Arkansas to $183.51 in Santa Clara County, CA. Mississippi pays $109.57. The RVUs are the same everywhere; the geographic indexes change the dollars.

Q4101 in Mississippi vs other payment areas

Mississippi · this page$109.57
Los Angeles, CA · California$150.55+$40.98
Washington, DC area · District of Columbia$149.91+$40.34
Miami, FL · Florida$132.47+$22.90
Chicago, IL · Illinois$127.89+$18.32
Manhattan, NY · New York$147.87+$38.30
Alaska · Alaska$135.53+$25.96

Other areas in Mississippi first, then benchmark localities. Bars start at $0.

Every other payment area

Q4101 in every other Medicare payment locality
Payment locality	Office	Facility
AlabamaAlabama	$111.35	—
ArkansasArkansas	$109.31	—
ArizonaArizona	$123.31	—
Bakersfield, CACalifornia	$139.47	—
Chico, CACalifornia	$139.47	—
El Centro, CACalifornia	$139.47	—
Fresno, CACalifornia	$139.47	—
Hanford, CACalifornia	$139.47	—
Madera, CACalifornia	$139.47	—
Merced, CACalifornia	$139.47	—
Modesto, CACalifornia	$139.47	—
Napa, CACalifornia	$167.73	—
Oxnard, CACalifornia	$150.42	—
Redding, CACalifornia	$139.47	—
Rest of CaliforniaCalifornia	$139.47	—
Riverside, CACalifornia	$139.47	—
Sacramento, CACalifornia	$148.00	—
Salinas, CACalifornia	$147.49	—
San Diego, CACalifornia	$152.20	—
Marin County, CACalifornia	$179.43	—
San Francisco, CACalifornia	$179.43	—
San Benito County, CACalifornia	$183.51	—
Santa Clara County, CACalifornia	$183.51	—
San Luis Obispo, CACalifornia	$144.95	—
Santa Cruz, CACalifornia	$154.62	—
Santa Maria, CACalifornia	$148.38	—
Santa Rosa, CACalifornia	$156.27	—
Stockton, CACalifornia	$139.47	—
Vallejo, CACalifornia	$167.73	—
Visalia, CACalifornia	$139.47	—
Yuba City, CACalifornia	$139.47	—
ColoradoColorado	$135.40	—
ConnecticutConnecticut	$137.06	—
DelawareDelaware	$125.73	—
Fort Lauderdale, FLFlorida	$128.91	—
Rest of FloridaFlorida	$121.66	—
Atlanta, GAGeorgia	$129.29	—
Rest of GeorgiaGeorgia	$113.51	—
Hawaii, Guam, HIHawaii	$144.69	—
IowaIowa	$116.44	—
IdahoIdaho	$117.08	—
East St. Louis, ILIllinois	$117.08	—
Rest of IllinoisIllinois	$116.19	—
Suburban Chicago, ILIllinois	$130.69	—
IndianaIndiana	$117.97	—
KansasKansas	$115.04	—
KentuckyKentucky	$113.13	—
New Orleans, LALouisiana	$119.75	—
Rest of LouisianaLouisiana	$112.62	—
Metropolitan Boston, MAMassachusetts	$151.95	—
Rest of MassachusettsMassachusetts	$134.00	—
Baltimore area, MDMaryland	$136.55	—
Rest of MarylandMaryland	$128.78	—
Rest of MaineMaine	$117.08	—
Southern Maine, MEMaine	$126.11	—
Detroit, MIMichigan	$122.80	—
Rest of MichiganMichigan	$116.19	—
MinnesotaMinnesota	$130.95	—
Metropolitan Kansas City, MOMissouri	$119.49	—
Metropolitan St. Louis, MOMissouri	$121.15	—
Rest of MissouriMissouri	$109.70	—
MontanaMontana	$127.26	—
North CarolinaNorth Carolina	$118.73	—
North DakotaNorth Dakota	$127.26	—
NebraskaNebraska	$117.46	—
New HampshireNew Hampshire	$132.47	—
Northern New JerseyNew Jersey	$147.62	—
Rest of New JerseyNew Jersey	$138.97	—
New MexicoNew Mexico	$116.70	—
NevadaNevada	$127.38	—
NYC suburbs and Long Island, NYNew York	$151.31	—
Poughkeepsie and northern NYC suburbs, NYNew York	$139.35	—
Queens, NYNew York	$150.42	—
Rest of New YorkNew York	$120.89	—
OhioOhio	$116.19	—
OklahomaOklahoma	$113.64	—
Portland, OROregon	$141.38	—
Rest of OregonOregon	$126.75	—
Metropolitan Philadelphia, PAPennsylvania	$132.47	—
Rest of PennsylvaniaPennsylvania	$116.82	—
Puerto RicoPuerto Rico	$128.66	—
Rhode IslandRhode Island	$131.46	—
South CarolinaSouth Carolina	$117.59	—
South DakotaSouth Dakota	$127.26	—
TennesseeTennessee	$115.68	—
Austin, TXTexas	$134.64	—
Beaumont, TXTexas	$115.80	—
Brazoria, TXTexas	$126.11	—
Dallas, TXTexas	$126.75	—
Fort Worth, TXTexas	$125.48	—
Galveston, TXTexas	$126.37	—
Houston, TXTexas	$126.37	—
Rest of TexasTexas	$120.77	—
UtahUtah	$119.62	—
VirginiaVirginia	$125.09	—
Virgin Islands, VIUnited States Virgin Islands	$128.66	—
VermontVermont	$125.98	—
Rest of WashingtonWashington	$134.00	—
King County, WAWashington	$156.14	—
WisconsinWisconsin	$121.91	—
West VirginiaWest Virginia	$110.59	—
WyomingWyoming	$127.26	—

Q4101 rates by state

Office rate range in each state. Select a state to see its payment localities.

ME WI VT NH MT ND MN MI NY MA RI WA ID WY SD IA IL IN OH PA NJ CT OR NV UT CO NE MO KY WV VA MD DE CA AZ NM KS OK AR TN NC SC DC TX LA MS AL GA FL AK HI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View every state and territory as a table

Q4101 office rate range by state
State / territory	Office rate range	Localities
AK	$135.53	1
AL	$111.35	1
AR	$109.31	1
AZ	$123.31	1
CA	$139.47–$183.51	29
CO	$135.40	1
CT	$137.06	1
DC	$149.91	1
DE	$125.73	1
FL	$121.66–$132.47	3
GA	$113.51–$129.29	2
GU	$144.69	1
HI	$144.69	1
IA	$116.44	1
ID	$117.08	1
IL	$116.19–$130.69	4
IN	$117.97	1
KS	$115.04	1
KY	$113.13	1
LA	$112.62–$119.75	2
MA	$134.00–$151.95	2
MD	$128.78–$149.91	3
ME	$117.08–$126.11	2
MI	$116.19–$122.80	2
MN	$130.95	1
MO	$109.70–$121.15	3
MS	$109.57	1
MT	$127.26	1
NC	$118.73	1
ND	$127.26	1
NE	$117.46	1
NH	$132.47	1
NJ	$138.97–$147.62	2
NM	$116.70	1
NV	$127.38	1
NY	$120.89–$151.31	5
OH	$116.19	1
OK	$113.64	1
OR	$126.75–$141.38	2
PA	$116.82–$132.47	2
PR	$128.66	1
RI	$131.46	1
SC	$117.59	1
SD	$127.26	1
TN	$115.68	1
TX	$115.80–$134.64	8
UT	$119.62	1
VA	$125.09–$149.91	2
VI	$128.66	1
VT	$125.98	1
WA	$134.00–$156.14	2
WI	$121.91	1
WV	$110.59	1
WY	$127.26	1

See Q4101 in every payment locality

How the Q4101 rate is calculated

Each of Q4101’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q4101

RVUs × geographic indexes × conversion factor

Office or facility?

Your ZIP

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense3.81

3.81 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

3.8100

Conversion factor

$33.4009

Medicare rate

$127.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Mississippi inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

18,201

Code: Q4101
Physician work: 0.00
Practice expense: 3.81
Malpractice: 0.00

GPCI2026.csv

Locality: Mississippi
Physician work: 1.000
Practice expense: 0.861
Malpractice: 0.739

Office calculation for Q4101 in Mississippi
Component	RVU	Locality factor	Adjusted
Physician work	0.00	× 1.000	0.0000
Practice expense	3.81	× 0.861	3.2804
Malpractice	0.00	× 0.739	0.0000
Total RVUs			3.2804
Conversion factor			× 33.4009

Office rate, Mississippi$109.57

Office: (0 × 1 + 3.81 × 0.861 + 0 × 0.739) × $33.4009 = $109.57

Open Q4101 in the RVU calculator

Payment rules and modifiers for Q4101

The CMS indicators that decide how Q4101 is paid alongside other services.

CMS payment indicators · Q4101

Skin substitute, apligraf, per square centimeter

Rule	CMS value	What it means
Global period	ZZZ	Add-on code: falls within the primary procedure’s global period.
Multiple procedures	0	No multiple-procedure reduction.
Bilateral (modifier 50)	0	The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)	0	Not paid without supporting documentation.
Co-surgeons (62)	0	Not permitted.
Team surgery (66)	0	Not permitted.
Professional/technical	3	Technical component only.

Codes related to Q4101

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q4101
Code	How it relates	Office range, Mississippi
Primary code
15271	Skin substitute graft, first 25 cm², trunk/limbsPrimary skin-substitute application procedure for qualifying trunk and extremity wounds.	$141.95
15275	Skin substitute, face and other specified sitesPrimary skin-substitute application procedure for qualifying wounds at other specified sites.	$145.49
Used instead
Q4102	Wound matrix, oasis wound matrixOasis wound matrix is a different skin-substitute product.	$109.57
Q4121	Skin substitute, theraSkin per square centimeterTheraSkin is a different skin-substitute product.	$109.57

How Q4101 has changed in Mississippi

Q4101 · Office / nonfacility

$109.57

Effective 2026-10-01

Compare with release effective

A rate is unavailable in one of these releases, so a change cannot be calculated.

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

January 1, 2026
RVU26A
No ratechanged to$109.57
Held through RVU26B, RVU26C, RVU26D.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D, RVU15A, RVU15B, RVU15C, RVU15D, RVU16A, RVU16B, RVU16C, RVU16D, RVU17A, RVU17B, RVU17C, RVU17D, RVU18AR1, RVU18B, RVU18C, RVU18D, RVU19A, RVU19B, RVU19C, RVU19D, RVU20A, RVU20B, RVU20C, RVU20D, RVU21A, RVU21B, RVU21C, RVU21D, RVU22A, RVU22B, RVU22C, RVU22D, RVU23A, RVU23B, RVU23C, RVU23D, RVU24A, RVU24AR, RVU24B, RVU24C, RVU24D, RVU25A, RVU25B, RVU25C, RVU25D.

Rates in every CMS release
Effective from	Office	Facility	CMS release
2026-10-01	$109.57	Not available in this setting	RVU26D
2026-07-01	$109.57	Not available in this setting	RVU26C
2026-04-01	$109.57	Not available in this setting	RVU26B
2026-01-01	$109.57	Not available in this setting	RVU26A
2025-10-01	Separate payment rules apply	Separate payment rules apply	RVU25D
2025-07-01	Separate payment rules apply	Separate payment rules apply	RVU25C
2025-04-01	Separate payment rules apply	Separate payment rules apply	RVU25B
2025-01-01	Separate payment rules apply	Separate payment rules apply	RVU25A
2024-10-01	Separate payment rules apply	Separate payment rules apply	RVU24D
2024-07-01	Separate payment rules apply	Separate payment rules apply	RVU24C
2024-04-01	Separate payment rules apply	Separate payment rules apply	RVU24B
2024-03-09	Separate payment rules apply	Separate payment rules apply	RVU24AR
2024-01-01	Separate payment rules apply	Separate payment rules apply	RVU24A
2023-10-01	Separate payment rules apply	Separate payment rules apply	RVU23D
2023-07-01	Separate payment rules apply	Separate payment rules apply	RVU23C
2023-04-01	Separate payment rules apply	Separate payment rules apply	RVU23B
2023-01-01	Separate payment rules apply	Separate payment rules apply	RVU23A
2022-10-01	Separate payment rules apply	Separate payment rules apply	RVU22D
2022-07-01	Separate payment rules apply	Separate payment rules apply	RVU22C
2022-04-01	Separate payment rules apply	Separate payment rules apply	RVU22B
2022-01-01	Separate payment rules apply	Separate payment rules apply	RVU22A
2021-10-01	Separate payment rules apply	Separate payment rules apply	RVU21D
2021-07-01	Separate payment rules apply	Separate payment rules apply	RVU21C
2021-04-01	Separate payment rules apply	Separate payment rules apply	RVU21B
2021-01-01	Separate payment rules apply	Separate payment rules apply	RVU21A
2020-10-01	Separate payment rules apply	Separate payment rules apply	RVU20D
2020-07-01	Separate payment rules apply	Separate payment rules apply	RVU20C
2020-04-01	Separate payment rules apply	Separate payment rules apply	RVU20B
2020-01-01	Separate payment rules apply	Separate payment rules apply	RVU20A
2019-10-01	Separate payment rules apply	Separate payment rules apply	RVU19D
2019-07-01	Separate payment rules apply	Separate payment rules apply	RVU19C
2019-04-01	Separate payment rules apply	Separate payment rules apply	RVU19B
2019-01-01	Separate payment rules apply	Separate payment rules apply	RVU19A
2018-10-01	Separate payment rules apply	Separate payment rules apply	RVU18D
2018-07-01	Separate payment rules apply	Separate payment rules apply	RVU18C
2018-04-01	Separate payment rules apply	Separate payment rules apply	RVU18B
2018-01-01	Separate payment rules apply	Separate payment rules apply	RVU18AR1
2017-10-01	Separate payment rules apply	Separate payment rules apply	RVU17D
2017-07-01	Separate payment rules apply	Separate payment rules apply	RVU17C
2017-04-01	Separate payment rules apply	Separate payment rules apply	RVU17B
2017-01-01	Separate payment rules apply	Separate payment rules apply	RVU17A
2016-10-01	Separate payment rules apply	Separate payment rules apply	RVU16D
2016-07-01	Separate payment rules apply	Separate payment rules apply	RVU16C
2016-04-01	Separate payment rules apply	Separate payment rules apply	RVU16B
2016-01-01	Separate payment rules apply	Separate payment rules apply	RVU16A
2015-10-01	Separate payment rules apply	Separate payment rules apply	RVU15D
2015-07-01	Separate payment rules apply	Separate payment rules apply	RVU15C
2015-04-01	Separate payment rules apply	Separate payment rules apply	RVU15B
2015-01-01	Separate payment rules apply	Separate payment rules apply	RVU15A
2014-10-01	Separate payment rules apply	Separate payment rules apply	RVU14D
2014-07-01	Separate payment rules apply	Separate payment rules apply	RVU14C
2014-04-01	Separate payment rules apply	Separate payment rules apply	RVU14B
2014-01-01	Separate payment rules apply	Separate payment rules apply	RVU14A
2013-10-01	Separate payment rules apply	Separate payment rules apply	RVU13D
2013-07-01	Separate payment rules apply	Separate payment rules apply	RVU13C
2013-04-01	Separate payment rules apply	Separate payment rules apply	RVU13B
2013-01-01	Separate payment rules apply	Separate payment rules apply	RVU13AR

Price Q4101 for an earlier date of service

Where the Mississippi rate applies

Mississippi is a Medicare payment area, not a city. Our Census mapping connects it to 427 cities and communities in Mississippi. Some span more than one payment area; confirm with the service ZIP.

Abbeville
Aberdeen
Ackerman
Agricola
Alcorn State University
Algoma
Alligator
Amory

Browse all communities in Mississippi

Q4101 billing questions

Does Q4101 report the Apligraf application?

No. Q4101 reports the Apligraf product; report the applicable skin-substitute application procedure separately as the primary service.

What is the unit of service?

Q4101 is measured per square centimeter. Document the wound area treated and the amount of Apligraf used.

Can Q4101 be billed by itself?

No. It is an add-on code and must be reported with a primary procedure, such as the applicable skin-substitute application code.

How does the global-period rule affect payment?

Q4101 is paid within the primary procedure’s global period. Its payment is tied to that procedure rather than treated as a separate standalone service.

Does Q4101 include an interpretation?

No. CMS classifies Q4101 as technical-component-only, and a separate code covers interpretation.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate

RVUs for Q4101PPRRVU2026_Oct_nonQPP.csv, line 18,201 (RVU26D)

18,198Q4074,,Iloprost non-comp unit dose,E,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00

18,199Q4081,,"Epoetin alfa, 100 units esrd",E,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00

18,200Q4082,,Drug/bio noc part b drug cap,E,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00

18,201Q4101,,Apligraf,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00

18,202Q4102,,Oasis wound matrix,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00

18,203Q4103,,Oasis burn matrix,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00

18,204Q4104,,Integra bmwd,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00

Geographic factors for MississippiGPCI2026.csv, line 67 (RVU26D)

6408202,MI,01,DETROIT,1.000,0.965,1.686

6508202,MI,99,REST OF MICHIGAN,1.000,0.913,1.129

6606202,MN,00,MINNESOTA,1.000,1.029,0.296

6707302,MS,00,MISSISSIPPI,1.000,0.861,0.739

6805302,MO,02,METROPOLITAN KANSAS CITY,1.000,0.939,0.977

6905302,MO,01,METROPOLITAN ST. LOUIS,1.000,0.952,1.002

7005302,MO,99,REST OF MISSOURI,1.000,0.862,0.974

Open CMS source How we calculate rates

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What Q4101 covers

How Mississippi compares for Q4101

Every other payment area

Q4101 rates by state

How the Q4101 rate is calculated

Payment rules and modifiers for Q4101

Codes related to Q4101

How Q4101 has changed in Mississippi

Where the Mississippi rate applies

Q4101 billing questions

Does Q4101 report the Apligraf application?

What is the unit of service?

Can Q4101 be billed by itself?

How does the global-period rule affect payment?

Does Q4101 include an interpretation?

Where these rates come from

Did this answer your question about what Q4101 pays in Mississippi?

Put Q4101 and the rest of your codes on one sheet