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HCPCS code Q5125: Releuko injection, per 1 mcg2026 Medicare rate & RVUs

Reports filgrastim-ayow, a filgrastim biosimilar used to support neutrophil production, with each billing unit representing 1 microgram.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare rate · Q5125

Releuko injection, per 1 mcg

Office or facility?

Work RVUs
0
Total RVUs
0.00
Global days
XXX

National rate · 2026

—

Not priced in the facility setting.

See every locality for Q5125 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What Q5125 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q5125 covers

Q5125 identifies filgrastim-ayow (Releuko), a biosimilar medicine that stimulates neutrophil production. It is used in oncology care to reduce neutropenia-related infection risk in patients receiving myelosuppressive cancer treatment. Clinicians administer filgrastim by subcutaneous injection or intravenous infusion; oncology and hematology practices, infusion centers, and hospitals may report the drug when furnished to a patient.

For Medicare, Q5125 has physician fee schedule status E and is excluded from that schedule. When covered, it is a Part B drug generally paid using CMS quarterly ASP drug pricing files. Coverage is left to the Medicare contractor’s judgment. Each unit represents 1 microgram of filgrastim-ayow, so the reported unit count corresponds to the administered dose in micrograms.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q5125 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

Q5125 office and facility rates by payment locality
Payment localityOfficeFacility
AlabamaUnavailableUnavailable
AlaskaUnavailableUnavailable
ArizonaUnavailableUnavailable
ArkansasUnavailableUnavailable
Atlanta, GAUnavailableUnavailable
Austin, TXUnavailableUnavailable
Bakersfield, CAUnavailableUnavailable
Baltimore area, MDUnavailableUnavailable
Beaumont, TXUnavailableUnavailable
Brazoria, TXUnavailableUnavailable

Q5125 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

View every state and territory as a table
Q5125 office rate range by state
State / territoryOffice rate rangeLocalities
AKNo published base rate1
ALNo published base rate1
ARNo published base rate1
AZNo published base rate1
CANo published base rate29
CONo published base rate1
CTNo published base rate1
DCNo published base rate1
DENo published base rate1
FLNo published base rate3
GANo published base rate2
GUNo published base rate1
HINo published base rate1
IANo published base rate1
IDNo published base rate1
ILNo published base rate4
INNo published base rate1
KSNo published base rate1
KYNo published base rate1
LANo published base rate2
MANo published base rate2
MDNo published base rate3
MENo published base rate2
MINo published base rate2
MNNo published base rate1
MONo published base rate3
MSNo published base rate1
MTNo published base rate1
NCNo published base rate1
NDNo published base rate1
NENo published base rate1
NHNo published base rate1
NJNo published base rate2
NMNo published base rate1
NVNo published base rate1
NYNo published base rate5
OHNo published base rate1
OKNo published base rate1
ORNo published base rate2
PANo published base rate2
PRNo published base rate1
RINo published base rate1
SCNo published base rate1
SDNo published base rate1
TNNo published base rate1
TXNo published base rate8
UTNo published base rate1
VANo published base rate2
VINo published base rate1
VTNo published base rate1
WANo published base rate2
WINo published base rate1
WVNo published base rate1
WYNo published base rate1

How the Q5125 rate is calculated

Each of Q5125’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q5125

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense0.00

0.00 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

0.0000

Conversion factor

$33.4009

Medicare rate

$0.00

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q5125

Q5125 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.

Place of service · Q5125

Which rate does Medicare pay?

The POS code on the claim line (CMS-1500 box 24B).

POS 11 · non-facility rate · national

—

Q5125 isn’t priced in this setting.

Q5125 compared with similar codes

Compare codes · National

4 codes, side by side

Office or facility?

  • Q5125

    Releuko injection, per 1 mcg0 wRVU

    Not priced

  • Q5101

    Zarxio injection, per 1 mcg0 wRVU

    Not priced

  • Q5110

    Nivestym, per 1 mcg0 wRVU

    Not priced

  • Q5120

    Pegfilgrastim-bmez, per 0.5 mg0 wRVU

    Not priced

How to choose

Q5101Zarxio injectionPer 1 mcg
Use Q5101 for filgrastim-sndz; Q5125 identifies filgrastim-ayow. Both are filgrastim biosimilars and use a 1-microgram unit.
Q5110NivestymPer 1 mcg
Q5110 identifies filgrastim-aafi, while Q5125 identifies filgrastim-ayow. Select the code matching the product administered.
Q5120Pegfilgrastim-bmezPer 0.5 mg
Q5120 identifies pegfilgrastim-bmez, a longer-acting related medicine reported in 0.5-mg units. Q5125 identifies filgrastim-ayow in 1-microgram units.

Codes related to Q5125

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q5125
CodeHow it relatesNational office range
Same family
Q5101Zarxio injection, per 1 mcgIdentifies filgrastim-sndz, another filgrastim biosimilar, billed per 1 microgram.No office rate
Q5110Nivestym, per 1 mcgIdentifies filgrastim-aafi, another filgrastim biosimilar, billed per 1 microgram.No office rate
Used instead
Q5120Pegfilgrastim-bmez, per 0.5 mgIdentifies pegfilgrastim-bmez, a longer-acting related neutrophil-stimulating drug with a different unit dose.No office rate

Q5125 billing questions

What drug does Q5125 identify?

It identifies filgrastim-ayow, marketed as Releuko, a biosimilar to filgrastim. It is used to stimulate neutrophil production.

How many units should be reported?

Each unit represents 1 microgram. Calculate units from the administered dose in micrograms.

How does Q5125 differ from Q5101 or Q5110?

Those codes identify different filgrastim biosimilars: Q5101 is filgrastim-sndz, and Q5110 is filgrastim-aafi. Q5125 is specific to filgrastim-ayow.

Does Medicare pay Q5125 under the physician fee schedule?

No. CMS assigns status E, excluding the code from the physician fee schedule. When covered, it is a Part B drug generally paid using CMS quarterly ASP drug pricing files.

Does Medicare automatically cover the drug?

No. Coverage is left to the Medicare contractor’s judgment.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates

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