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HCPCS code Q5101: Zarxio injection, per 1 mcg2026 Medicare rate & RVUs

Reports filgrastim-sndz, a filgrastim biosimilar used to support neutrophil recovery, with each unit representing 1 microgram of drug.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare rate · Q5101

Zarxio injection, per 1 mcg

Office or facility?

Work RVUs
0
Total RVUs
0.00
Global days
XXX

National rate · 2026

—

Not priced in the facility setting.

See every locality for Q5101 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What Q5101 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q5101 covers

Q5101 identifies Zarxio (filgrastim-sndz), a biosimilar granulocyte colony-stimulating factor used to increase neutrophils. Clinicians commonly use filgrastim products for patients with chemotherapy-related neutropenia, certain other severe neutropenia conditions, or to mobilize blood-forming stem cells. Administration may be subcutaneous or intravenous, depending on the clinical use and treatment plan. Oncology practices and infusion centers commonly report the drug code for the product administered.

CMS assigns this code physician fee schedule status E, meaning it is excluded from the physician fee schedule; when Medicare covers it, payment is under another method. CMS classifies it as a Part B drug, generally priced from quarterly Average Sales Price files when covered, and assigns special Medicare coverage instructions. Each unit represents 1 microgram of filgrastim-sndz, so report units based on the administered drug dose.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q5101 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

Q5101 office and facility rates by payment locality
Payment localityOfficeFacility
AlabamaUnavailableUnavailable
AlaskaUnavailableUnavailable
ArizonaUnavailableUnavailable
ArkansasUnavailableUnavailable
Atlanta, GAUnavailableUnavailable
Austin, TXUnavailableUnavailable
Bakersfield, CAUnavailableUnavailable
Baltimore area, MDUnavailableUnavailable
Beaumont, TXUnavailableUnavailable
Brazoria, TXUnavailableUnavailable

Q5101 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

View every state and territory as a table
Q5101 office rate range by state
State / territoryOffice rate rangeLocalities
AKNo published base rate1
ALNo published base rate1
ARNo published base rate1
AZNo published base rate1
CANo published base rate29
CONo published base rate1
CTNo published base rate1
DCNo published base rate1
DENo published base rate1
FLNo published base rate3
GANo published base rate2
GUNo published base rate1
HINo published base rate1
IANo published base rate1
IDNo published base rate1
ILNo published base rate4
INNo published base rate1
KSNo published base rate1
KYNo published base rate1
LANo published base rate2
MANo published base rate2
MDNo published base rate3
MENo published base rate2
MINo published base rate2
MNNo published base rate1
MONo published base rate3
MSNo published base rate1
MTNo published base rate1
NCNo published base rate1
NDNo published base rate1
NENo published base rate1
NHNo published base rate1
NJNo published base rate2
NMNo published base rate1
NVNo published base rate1
NYNo published base rate5
OHNo published base rate1
OKNo published base rate1
ORNo published base rate2
PANo published base rate2
PRNo published base rate1
RINo published base rate1
SCNo published base rate1
SDNo published base rate1
TNNo published base rate1
TXNo published base rate8
UTNo published base rate1
VANo published base rate2
VINo published base rate1
VTNo published base rate1
WANo published base rate2
WINo published base rate1
WVNo published base rate1
WYNo published base rate1

How the Q5101 rate is calculated

Each of Q5101’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q5101

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense0.00

0.00 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

0.0000

Conversion factor

$33.4009

Medicare rate

$0.00

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q5101

Q5101 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.

Place of service · Q5101

Which rate does Medicare pay?

The POS code on the claim line (CMS-1500 box 24B).

POS 11 · non-facility rate · national

—

Q5101 isn’t priced in this setting.

Q5101 compared with similar codes

Compare codes · National

5 codes, side by side

Office or facility?

  • Q5101

    Zarxio injection, per 1 mcg0 wRVU

    Not priced

  • Q5110

    Nivestym, per 1 mcg0 wRVU

    Not priced

  • Q5125

    Releuko injection, per 1 mcg0 wRVU

    Not priced

  • Q5108

    Fulphila injection, per 0.5 mg0 wRVU

    Not priced

  • J1442

    Filgrastim injection, per 1 microgram0 wRVU

    Not priced

How to choose

Q5110NivestymPer 1 mcg
Q5110 identifies Nivestym, a different filgrastim biosimilar. Q5101 is specific to filgrastim-sndz (Zarxio).
Q5125Releuko injectionPer 1 mcg
Q5125 identifies Releuko, not Zarxio. Select the code for the filgrastim product actually administered.
Q5108Fulphila injectionPer 0.5 mg
Q5108 is for pegfilgrastim-jmdb (Fulphila), a different, longer-acting drug. Q5101 is for filgrastim-sndz and counts each microgram.
J1442Filgrastim injectionPer 1 microgram
J1442 identifies filgrastim rather than the filgrastim-sndz biosimilar. Use Q5101 when the administered product is Zarxio.

Codes related to Q5101

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q5101
CodeHow it relatesNational office range
Same family
Q5110Nivestym, per 1 mcgNivestym is another filgrastim biosimilar reported with its own code.No office rate
Q5125Releuko injection, per 1 mcgReleuko is another filgrastim biosimilar reported with its own code.No office rate
Used instead
Q5108Fulphila injection, per 0.5 mgFulphila is a pegfilgrastim product used for neutrophil support with a different drug and dosing schedule.No office rate

Q5101 billing questions

When should Q5101 be used instead of another filgrastim code?

Use Q5101 for filgrastim-sndz (Zarxio). Other filgrastim biosimilar products have their own HCPCS codes, including Q5110 for Nivestym and Q5125 for Releuko.

How many units should be reported?

Each unit represents 1 microgram. Divide the administered filgrastim-sndz dose in micrograms by 1 to determine the drug units.

What should documentation identify?

Document the Zarxio product administered and the dose in micrograms; each microgram supports one Q5101 unit.

How does Medicare treat Q5101?

CMS excludes Q5101 from the physician fee schedule with status E. When Medicare covers the drug, it is paid under another method; CMS identifies it as a Part B drug generally priced through quarterly ASP files and assigns special coverage instructions.

Is Q5101 interchangeable for billing with pegfilgrastim codes?

No. Q5101 represents filgrastim-sndz per microgram; pegfilgrastim products have separate codes and dosing units.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates

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