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HCPCS Q4378: Wound matrixMedicare rate & RVUs

Reports each square centimeter of Renew FT Matrix supplied with a primary wound procedure that applies a matrix to a treated wound bed.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare pays $127.26 for Q4378 nationally in the office. Local office rates run $109.31–$183.51.

Medicare rate · Q4378

Wound matrix

Work RVUs
0
Total RVUs
3.81
Global days
ZZZ

National rate · 2026

$127.26

Office setting, before claim adjustments.

See every locality for Q4378 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

On this page 10 sections
  1. Medicare rate
  2. What Q4378 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q4378 covers

Q4378 identifies the Renew FT Matrix product used in wound care. A clinician applies the matrix to a prepared wound bed as part of treatment; the product line represents the material, not the work of preparing the site or applying it. It is reported by the area of product supplied, rather than by the number of wounds or applications. The related application service is generally reported separately.

Report the product only with a primary procedure, using documentation that identifies Renew FT Matrix and supports the square-centimeter quantity supplied. CMS treats Q4378 as an add-on, paid within the primary procedure’s global period. CMS also classifies it as technical-component-only; a separate code covers interpretation. The product code does not replace the application procedure code, and its units should reflect the area documented for the product used.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4378 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 payment localities

$109.31 to $183.51

$109.31$146.41$183.51
One dot per payment locality, office / nonfacility. Hover a dot to see the locality; select it to open that rate.

109 of 109 payment localities

Q4378 office and facility rates by payment locality
Payment localityOfficeFacility
Alabama$111.35Unavailable
Alaska*$135.53Unavailable
Arizona$123.31Unavailable
Arkansas$109.31Unavailable
Atlanta$129.29Unavailable
Austin$134.64Unavailable
Bakersfield$139.47Unavailable
Baltimore/Surr. Cntys$136.55Unavailable
Beaumont$115.80Unavailable
Brazoria$126.11Unavailable

Q4378 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
Q4378 office rate range by state
State / territoryOffice rate rangeLocalities
AK$135.531
AL$111.351
AR$109.311
AZ$123.311
CA$139.47–$183.5129
CO$135.401
CT$137.061
DC$149.911
DE$125.731
FL$121.66–$132.473
GA$113.51–$129.292
GU$144.691
HI$144.691
IA$116.441
ID$117.081
IL$116.19–$130.694
IN$117.971
KS$115.041
KY$113.131
LA$112.62–$119.752
MA$134.00–$151.952
MD$128.78–$149.913
ME$117.08–$126.112
MI$116.19–$122.802
MN$130.951
MO$109.70–$121.153
MS$109.571
MT$127.261
NC$118.731
ND$127.261
NE$117.461
NH$132.471
NJ$138.97–$147.622
NM$116.701
NV$127.381
NY$120.89–$151.315
OH$116.191
OK$113.641
OR$126.75–$141.382
PA$116.82–$132.472
PR$128.661
RI$131.461
SC$117.591
SD$127.261
TN$115.681
TX$115.80–$134.648
UT$119.621
VA$125.09–$149.912
VI$128.661
VT$125.981
WA$134.00–$156.142
WI$121.911
WV$110.591
WY$127.261

How the Q4378 rate is calculated

Each of Q4378’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q4378

RVUs × geographic indexes × conversion factor

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense3.81

3.81 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

3.8100

Conversion factor

$33.4009

Medicare rate

$127.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q4378

The CMS indicators that decide how Q4378 is paid alongside other services.

CMS payment indicators · Q4378

Wound matrix

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical3Technical component only.

Q4378 compared with similar codes

Compare codes · National

5 codes, side by side

  • Q4378

    Wound matrix0 wRVU

    $127.26

  • 15271

    Skin substitute graft1.46 wRVU

    $157.99+$30.73

  • 15275

    Skin substitute1.78 wRVU

    $160.32+$33.06

  • Q4377

    Skin substitute0 wRVU

    $127.26+$0.00

  • Q4379

    Wound graft0 wRVU

    $127.26+$0.00

How to choose

15271Skin substitute graft
This is an application procedure for qualifying trunk or extremity sites; Q4378 reports Renew FT Matrix supplied with the primary procedure.
15275Skin substitute
This application procedure covers qualifying head, neck, hand, foot, or genital sites. Q4378 identifies the product, not the application or anatomical site.
Q4377Skin substitute
Q4377 identifies Trigraft FT, whereas Q4378 identifies Renew FT Matrix. Report the product actually supplied.
Q4379Wound graft
Q4379 identifies Amniodefend FT, not Renew FT Matrix. The product-specific code follows the material used.

Codes related to Q4378

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q4378
CodeHow it relatesNational office range
Primary code
15271Skin substitute graftPrimary application procedure for a skin substitute graft on qualifying trunk or extremity sites.$140.17–$205.27
15275Skin substitutePrimary application procedure for a skin substitute graft on qualifying head, neck, hand, foot, or genital sites.$143.80–$205.40
Used instead
Q4377Skin substituteIdentifies Trigraft FT, a different wound matrix product.$109.31–$183.51
Q4379Wound graftIdentifies Amniodefend FT, a different wound matrix product.$109.31–$183.51

Q4378 billing questions

Is Q4378 the wound application procedure?

No. It identifies the Renew FT Matrix product by square centimeter. Report the wound application procedure separately when performed.

What should support the units?

Document the product used and the square-centimeter area supplied. Do not base units on the number of wounds alone.

Can Q4378 be reported by itself?

No. CMS identifies it as an add-on code that must be billed with a primary procedure.

How does the global-period rule affect this code?

Payment for Q4378 is within the primary procedure’s global period. It is not separately paid outside that procedure’s global period.

Is there a separate professional interpretation component?

CMS classifies Q4378 as technical-component-only, with interpretation covered by a separate code.

How is Q4378 different from Q4377 or Q4379?

Those codes identify Trigraft FT and Amniodefend FT, respectively. Select the code matching the product actually supplied; their product quantities are not interchangeable.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for Q4378PPRRVU2026_Oct_nonQPP.csv, line 18,464 (RVU26D)

Open CMS sourceHow we calculate rates

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