HCPCS Q4222: Wound matrixMedicare rate & RVUs in Florida
Q4222 reports ProgenaMatrix supplied for wound treatment, measured by square centimeter and billed with the associated primary procedure.
Medicare pays $121.66–$132.47 for Q4222 in the office in Florida, from Rest Of Florida to Miami. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 9 sections
What Q4222 covers
Q4222 identifies ProgenaMatrix supplied for use as a wound matrix, with quantity measured in square centimeters. It represents the product, not the clinician’s wound evaluation or application work. A physician or other qualified practitioner may place the material during treatment of a skin wound in an office or facility setting, alongside the primary wound procedure.
Report Q4222 only with a primary procedure; CMS treats it as an add-on and pays it within that procedure’s global period. Document the product used and the square-centimeter quantity represented by the units billed. The code is technical-component-only, with a separate code covering interpretation. CMS assigns no physician-work RVU to Q4222; its RVUs reflect practice expense.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4222 pays more and less in Florida
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
3 payment localities
$121.66 to $132.47
| Payment locality | Office | Facility |
|---|---|---|
| Fort Lauderdale | $128.91 | Unavailable |
| Miami | $132.47 | Unavailable |
| Rest Of Florida | $121.66 | Unavailable |
How the Q4222 rate is calculated
Each of Q4222’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4222
RVUs × geographic indexes × conversion factor
Swap in your local Medicare rate.
Work 0.00Practice expense 3.81Malpractice 0.00
All indexes start at 1.000 (the national rate). Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4222
The CMS indicators that decide how Q4222 is paid alongside other services.
CMS payment indicators · Q4222
Wound matrix
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4222 compared with similar codes
Compare codes
Q4222 vs Q4221 vs Q4223 vs Q4220: national Medicare rates
Swap in your local Medicare rate.
How to choose
- Q4221Wound product
- Q4221 identifies Amniowrap2, while Q4222 identifies ProgenaMatrix. Select the code matching the product supplied.
- Q4223Ocular membrane product
- Q4223 identifies Dermabind SL optic rather than ProgenaMatrix. Both descriptors use square-centimeter units, but the product identity determines the code.
- Q4220Skin substitute
- Q4220 identifies Bellacell HD or SureDerm. Q4222 is specific to ProgenaMatrix, so the products are not distinguished by unit of measure alone.
Q4222 billing questions
Can Q4222 be billed by itself?
No. CMS identifies it as an add-on code that must be billed with a primary procedure and is paid within that procedure’s global period.
How should the units be determined?
Use the square-centimeter quantity of ProgenaMatrix represented by the units billed. Documentation should identify the product and quantity supplied.
Does Q4222 report the wound assessment or application work?
No. Q4222 identifies the product; the primary procedure reports the associated wound service.
Does Q4222 include interpretation?
No. CMS classifies Q4222 as technical-component-only; a separate code covers interpretation.
Can another per-square-centimeter wound product be reported as Q4222?
No. Q4222 is specific to ProgenaMatrix. Use the code for the product actually supplied, such as Q4221 or Q4223 when that named product is used.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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