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HCPCS Q4222: Wound matrixMedicare rate & RVUs

Q4222 reports ProgenaMatrix supplied for wound treatment, measured by square centimeter and billed with the associated primary procedure.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare pays $127.26 for Q4222 nationally in the office. Local office rates run $109.31–$183.51.

Medicare rate · Q4222

Wound matrix

Work RVUs
0
Total RVUs
3.81
Global days
ZZZ

National rate · 2026

$127.26

Office setting, before claim adjustments.

See every locality for Q4222 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

On this page 10 sections
  1. Medicare rate
  2. What Q4222 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q4222 covers

Q4222 identifies ProgenaMatrix supplied for use as a wound matrix, with quantity measured in square centimeters. It represents the product, not the clinician’s wound evaluation or application work. A physician or other qualified practitioner may place the material during treatment of a skin wound in an office or facility setting, alongside the primary wound procedure.

Report Q4222 only with a primary procedure; CMS treats it as an add-on and pays it within that procedure’s global period. Document the product used and the square-centimeter quantity represented by the units billed. The code is technical-component-only, with a separate code covering interpretation. CMS assigns no physician-work RVU to Q4222; its RVUs reflect practice expense.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4222 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 payment localities

$109.31 to $183.51

$109.31$146.41$183.51
One dot per payment locality, office / nonfacility. Hover a dot to see the locality; select it to open that rate.

109 of 109 payment localities

Q4222 office and facility rates by payment locality
Payment localityOfficeFacility
Alabama$111.35Unavailable
Alaska*$135.53Unavailable
Arizona$123.31Unavailable
Arkansas$109.31Unavailable
Atlanta$129.29Unavailable
Austin$134.64Unavailable
Bakersfield$139.47Unavailable
Baltimore/Surr. Cntys$136.55Unavailable
Beaumont$115.80Unavailable
Brazoria$126.11Unavailable

Q4222 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
Q4222 office rate range by state
State / territoryOffice rate rangeLocalities
AK$135.531
AL$111.351
AR$109.311
AZ$123.311
CA$139.47–$183.5129
CO$135.401
CT$137.061
DC$149.911
DE$125.731
FL$121.66–$132.473
GA$113.51–$129.292
GU$144.691
HI$144.691
IA$116.441
ID$117.081
IL$116.19–$130.694
IN$117.971
KS$115.041
KY$113.131
LA$112.62–$119.752
MA$134.00–$151.952
MD$128.78–$149.913
ME$117.08–$126.112
MI$116.19–$122.802
MN$130.951
MO$109.70–$121.153
MS$109.571
MT$127.261
NC$118.731
ND$127.261
NE$117.461
NH$132.471
NJ$138.97–$147.622
NM$116.701
NV$127.381
NY$120.89–$151.315
OH$116.191
OK$113.641
OR$126.75–$141.382
PA$116.82–$132.472
PR$128.661
RI$131.461
SC$117.591
SD$127.261
TN$115.681
TX$115.80–$134.648
UT$119.621
VA$125.09–$149.912
VI$128.661
VT$125.981
WA$134.00–$156.142
WI$121.911
WV$110.591
WY$127.261

How the Q4222 rate is calculated

Each of Q4222’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q4222

RVUs × geographic indexes × conversion factor

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense3.81

3.81 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

3.8100

Conversion factor

$33.4009

Medicare rate

$127.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q4222

The CMS indicators that decide how Q4222 is paid alongside other services.

CMS payment indicators · Q4222

Wound matrix

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical3Technical component only.

Q4222 compared with similar codes

Compare codes · National

4 codes, side by side

  • Q4222

    Wound matrix0 wRVU

    $127.26

  • Q4221

    Wound product0 wRVU

    $127.26+$0.00

  • Q4223

    Ocular membrane product0 wRVU

    $127.26+$0.00

  • Q4220

    Skin substitute0 wRVU

    $127.26+$0.00

How to choose

Q4221Wound product
Q4221 identifies Amniowrap2, while Q4222 identifies ProgenaMatrix. Select the code matching the product supplied.
Q4223Ocular membrane product
Q4223 identifies Dermabind SL optic rather than ProgenaMatrix. Both descriptors use square-centimeter units, but the product identity determines the code.
Q4220Skin substitute
Q4220 identifies Bellacell HD or SureDerm. Q4222 is specific to ProgenaMatrix, so the products are not distinguished by unit of measure alone.

Codes related to Q4222

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q4222
CodeHow it relatesNational office range
Used instead
Q4221Wound productAmniowrap2 is another named wound product measured per square centimeter.$109.31–$183.51
Q4223Ocular membrane productDermabind SL optic is a different named product with per-square-centimeter reporting.$109.31–$183.51
Q4224Wound matrixHHF10-P is another named product reported per square centimeter.$109.31–$183.51
Q4220Skin substituteBellacell HD or SureDerm is a different named product with square-centimeter reporting.$109.31–$183.51

Q4222 billing questions

Can Q4222 be billed by itself?

No. CMS identifies it as an add-on code that must be billed with a primary procedure and is paid within that procedure’s global period.

How should the units be determined?

Use the square-centimeter quantity of ProgenaMatrix represented by the units billed. Documentation should identify the product and quantity supplied.

Does Q4222 report the wound assessment or application work?

No. Q4222 identifies the product; the primary procedure reports the associated wound service.

Does Q4222 include interpretation?

No. CMS classifies Q4222 as technical-component-only; a separate code covers interpretation.

Can another per-square-centimeter wound product be reported as Q4222?

No. Q4222 is specific to ProgenaMatrix. Use the code for the product actually supplied, such as Q4221 or Q4223 when that named product is used.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for Q4222PPRRVU2026_Oct_nonQPP.csv, line 18,313 (RVU26D)

Open CMS sourceHow we calculate rates

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