CPT code 88342: Antibody stain, first single antibody per specimen2026 Medicare rate & RVUs in Oklahoma

Report 88342 for the first single-antibody immunohistochemical or immunocytochemical stain on each specimen when a pathologist interprets stained tissue or cells.

CMS RVU26DEffective Oct 1, 2026One payment locality2.4M Medicare services in 2024

In Oklahoma, Medicare pays $100.78 for 88342 in the office.

$100.78Office (non-facility)
Not available in this settingHospital or facility
−8.6%vs the national office rate ($110.22)

Check a contract rate as a % of Medicare · 88342 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 88342 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Oklahoma
  2. What 88342 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 88342 covers

Code 88342 covers the first single-antibody immunohistochemical or immunocytochemical stain on a tissue or cytology specimen, such as a cell block. A histology laboratory prepares the stained material, and a pathologist interprets the result to characterize a tumor, identify metastatic carcinoma in a lymph node, or investigate an infectious organism. These services may be performed in hospital, independent, or office-based laboratories.

Report one unit per separately identifiable specimen receiving a single-antibody stain, not per slide or tissue block. Use 88341 for additional single-antibody stains on that specimen and 88344 for a multiplex antibody stain procedure. Controls are included rather than counted as additional units. Documentation should identify the specimen, antibodies, and findings. CMS recognizes a technical component (modifier TC) for stain preparation, reagents, staff, and equipment, and a professional component (modifier 26) for interpretation. An entity performing both reports the global service without a modifier. A pathologist interpreting staining performed by a hospital laboratory generally reports 88342 with modifier 26.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Oklahoma compares for 88342

Across 109 of 109 payment localities, the office rate for 88342 runs from $97.65 in Arkansas to $150.80 in San Benito County, CA. Oklahoma pays $100.78. The RVUs are the same everywhere; the geographic indexes change the dollars.

88342 in Oklahoma vs other payment areas
  1. Oklahoma · this page$100.78
  2. Los Angeles, CA · California$126.82+$26.04
  3. Washington, DC area · District of Columbia$126.98+$26.20
  4. Miami, FL · Florida$114.80+$14.02
  5. Chicago, IL · Illinois$111.68+$10.90
  6. Manhattan, NY · New York$126.14+$25.36
  7. Alaska · Alaska$126.92+$26.14

Other areas in Oklahoma first, then benchmark localities. Bars start at $0.

Every other payment area

88342 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$99.08—
ArkansasArkansas$97.65—
ArizonaArizona$107.43—
Bakersfield, CACalifornia$118.73—
Chico, CACalifornia$118.64—
El Centro, CACalifornia$118.64—
Fresno, CACalifornia$118.64—
Hanford, CACalifornia$118.64—

88342 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$97.65

$134.72

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
88342 office rate range by state
State / territoryOffice rate rangeLocalities
AK$126.921
AL$99.081
AR$97.651
AZ$107.431
CA$118.64–$150.8029
CO$115.911
CT$117.501
DC$126.981
DE$109.231
FL$106.74–$114.803
GA$100.97–$111.812
GU$121.841
HI$121.841
IA$102.441
ID$102.921
IL$103.04–$113.244
IN$103.541
KS$101.551
KY$100.531
LA$100.21–$105.192
MA$115.05–$127.932
MD$111.44–$126.983
ME$103.02–$109.192
MI$102.75–$107.642
MN$112.271
MO$98.22–$106.063
MS$97.981
MT$110.221
NC$104.161
ND$109.831
NE$103.121
NH$113.701
NJ$119.19–$125.592
NM$103.151
NV$110.201
NY$105.68–$128.665
OH$102.671
OK$100.781
OR$109.68–$120.052
PA$103.07–$114.322
PR$111.171
RI$113.451
SC$103.521
SD$109.781
TN$102.011
TX$102.36–$115.238
UT$104.941
VA$108.55–$126.982
VI$111.171
VT$109.021
WA$114.96–$130.952
WI$106.111
WV$99.131
WY$110.051

See 88342 in every payment locality

How the 88342 rate is calculated

Each of 88342’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 88342

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.68

0.68 RVUs× 1.000 GPCI

Practice expense2.60

2.60 RVUs× 1.000 GPCI

Malpractice0.02

0.02 RVUs× 1.000 GPCI

Adjusted RVUs

3.3000

Conversion factor

$33.4009

Medicare rate

$110.22

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Oklahoma inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

11,251

Code
88342
Physician work
0.68
Practice expense
2.60
Malpractice
0.02

GPCI2026.csv

86

Locality
Oklahoma
Physician work
1.000
Practice expense
0.893
Malpractice
0.777
Office calculation for 88342 in Oklahoma
ComponentRVULocality factorAdjusted
Physician work0.68× 1.0000.6800
Practice expense2.60× 0.8932.3218
Malpractice0.02× 0.7770.0155
Total RVUs3.0173
Conversion factor× 33.4009

Office rate, Oklahoma$100.78

Office: (0.68 × 1 + 2.6 × 0.893 + 0.02 × 0.777) × $33.4009 = $100.78

Open 88342 in the RVU calculator

Payment rules and modifiers for 88342

The CMS indicators that decide how 88342 is paid alongside other services.

CMS payment indicators · 88342

Antibody stain, first single antibody per specimen

RuleCMS valueWhat it means
Global periodXXXThe global surgery concept doesn’t apply.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical1Diagnostic test with separate professional (26) and technical (TC) components.

What modifiers do to the payment

Modifier 26 · payment effect

With and without the modifier

88342 without 26 · national office

$110.22

Antibody stain, first single antibody per specimen

88342-26 · Professional component

$32.73

Pays only the interpretation and report.

When to use modifier 26

How 88342 has changed in Oklahoma

88342 · Office / nonfacility

$100.78

Effective 2026-10-01

The base rate is $1.24 higher than on 2025-10-01, moving from $99.54 to $100.78 (1.2%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $99.54changed to$100.78

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.70 changed to 0.68
    • Practice expense RVU 2.65 changed to 2.60
    • Practice expense GPCI 0.891 changed to 0.893
    • Malpractice GPCI 0.813 changed to 0.777

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $96.80changed to$99.54

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 2.46 changed to 2.65

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $95.22changed to$96.80

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $92.12changed to$95.22

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 2.26 changed to 2.46
    • Practice expense GPCI 0.886 changed to 0.891
    • Malpractice GPCI 0.798 changed to 0.813
  5. January 1, 2023

    RVU23A

    $93.06changed to$92.12

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 2.24 changed to 2.26
    • Practice expense GPCI 0.881 changed to 0.886
    • Malpractice GPCI 0.782 changed to 0.798

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $96.29changed to$93.06

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 2.32 changed to 2.24

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $97.83changed to$96.29

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 2.25 changed to 2.32
    • Practice expense GPCI 0.886 changed to 0.881
    • Malpractice GPCI 0.868 changed to 0.782

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $99.47changed to$97.83

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 2.28 changed to 2.25
    • Malpractice RVU 0.03 changed to 0.02
    • Practice expense GPCI 0.891 changed to 0.886
    • Malpractice GPCI 0.954 changed to 0.868

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $102.25changed to$99.47

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 2.37 changed to 2.28

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $98.58changed to$102.25

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 2.29 changed to 2.37
    • Practice expense GPCI 0.882 changed to 0.891
    • Malpractice GPCI 0.900 changed to 0.954

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $96.84changed to$98.58

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 2.27 changed to 2.29
    • Practice expense GPCI 0.872 changed to 0.882
    • Malpractice GPCI 0.845 changed to 0.900

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $82.48changed to$96.84

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 1.81 changed to 2.27
    • Malpractice RVU 0.02 changed to 0.03

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $82.06changed to$82.48

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    No ratechanged to$82.06

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $102.73changed toNo rate

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $102.73

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$100.78Not available in this settingRVU26D
2026-07-01$100.78Not available in this settingRVU26C
2026-04-01$100.78Not available in this settingRVU26B
2026-01-01$100.78Not available in this settingRVU26A
2025-10-01$99.54Not available in this settingRVU25D
2025-07-01$99.54Not available in this settingRVU25C
2025-04-01$99.54Not available in this settingRVU25B
2025-01-01$99.54Not available in this settingRVU25A
2024-10-01$96.80Not available in this settingRVU24D
2024-07-01$96.80Not available in this settingRVU24C
2024-04-01$96.80Not available in this settingRVU24B
2024-03-09$96.80Not available in this settingRVU24AR
2024-01-01$95.22Not available in this settingRVU24A
2023-10-01$92.12Not available in this settingRVU23D
2023-07-01$92.12Not available in this settingRVU23C
2023-04-01$92.12Not available in this settingRVU23B
2023-01-01$92.12Not available in this settingRVU23A
2022-10-01$93.06Not available in this settingRVU22D
2022-07-01$93.06Not available in this settingRVU22C
2022-04-01$93.06Not available in this settingRVU22B
2022-01-01$93.06Not available in this settingRVU22A
2021-10-01$96.29Not available in this settingRVU21D
2021-07-01$96.29Not available in this settingRVU21C
2021-04-01$96.29Not available in this settingRVU21B
2021-01-01$96.29Not available in this settingRVU21A
2020-10-01$97.83Not available in this settingRVU20D
2020-07-01$97.83Not available in this settingRVU20C
2020-04-01$97.83Not available in this settingRVU20B
2020-01-01$97.83Not available in this settingRVU20A
2019-10-01$99.47Not available in this settingRVU19D
2019-07-01$99.47Not available in this settingRVU19C
2019-04-01$99.47Not available in this settingRVU19B
2019-01-01$99.47Not available in this settingRVU19A
2018-10-01$102.25Not available in this settingRVU18D
2018-07-01$102.25Not available in this settingRVU18C
2018-04-01$102.25Not available in this settingRVU18B
2018-01-01$102.25Not available in this settingRVU18AR1
2017-10-01$98.58Not available in this settingRVU17D
2017-07-01$98.58Not available in this settingRVU17C
2017-04-01$98.58Not available in this settingRVU17B
2017-01-01$98.58Not available in this settingRVU17A
2016-10-01$96.84Not available in this settingRVU16D
2016-07-01$96.84Not available in this settingRVU16C
2016-04-01$96.84Not available in this settingRVU16B
2016-01-01$96.84Not available in this settingRVU16A
2015-10-01$82.48Not available in this settingRVU15D
2015-07-01$82.48Not available in this settingRVU15C
2015-04-01$82.06Not available in this settingRVU15B
2015-01-01$82.06Not available in this settingRVU15A
2014-10-01Separate payment rules applySeparate payment rules applyRVU14D
2014-07-01Separate payment rules applySeparate payment rules applyRVU14C
2014-04-01Separate payment rules applySeparate payment rules applyRVU14B
2014-01-01Separate payment rules applySeparate payment rules applyRVU14A
2013-10-01$102.73Not available in this settingRVU13D
2013-07-01$102.73Not available in this settingRVU13C
2013-04-01$102.73Not available in this settingRVU13B
2013-01-01$102.73Not available in this settingRVU13AR

Price 88342 for an earlier date of service

Where the Oklahoma rate applies

Oklahoma is a Medicare payment area, not a city. Our Census mapping connects it to 846 cities and communities in Oklahoma. Some span more than one payment area; confirm with the service ZIP.

  • Lahoma
  • Achille
  • Ada
  • Adair
  • Adams
  • Adamson
  • Addington
  • Afton

Browse all communities in Oklahoma

88342 billing questions

How many units of this code can be reported when several antibodies are run on one specimen?

Report one unit of 88342 for the first single-antibody stain on that specimen. Report each additional single-antibody stain on the same specimen with add-on code 88341.

If two separate specimens each receive single-antibody stains, can this code be reported twice?

Yes. Report 88342 once for each separately identifiable specimen receiving a single-antibody stain, with 88341 for additional single-antibody stains on each specimen.

Are control slides billed separately?

No. Positive and negative controls run with the stain are included and are not counted as additional units.

When should 88360 or 88361 be used instead?

Use 88360 for manual or 88361 for computer-assisted quantitative or semiquantitative tumor immunostaining, such as ER, PR, or HER2 scoring. Do not also report 88342 for the same antibody on the same specimen.

Which modifier does a pathologist use when the hospital lab performs the staining?

The pathologist reports modifier 26 for the interpretation; the hospital performs the technical work. An entity performing both components reports the global code without a modifier.

Does a stain with two antibodies on one slide count here?

Use 88344 when the service is a multiplex antibody stain procedure. Combining antibodies in a cocktail does not, by itself, establish that a multiplex procedure was performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 88342PPRRVU2026_Oct_nonQPP.csv, line 11,251 (RVU26D)
Geographic factors for OklahomaGPCI2026.csv, line 86 (RVU26D)

Open CMS sourceHow we calculate rates

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