CPT code 88350: Immunofluorescence, each additional antibody stain2026 Medicare rate & RVUs in South Dakota
Reports each additional single-antibody immunofluorescence stain performed after the first stain, such as in renal or skin biopsy evaluation.
In South Dakota, Medicare pays $106.44 for 88350 in the office.
Check a contract rate as a % of Medicare · 88350 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88350 covers
A pathology laboratory performs an additional immunofluorescence stain to detect a specific antibody or immune reactant in tissue. The pathologist interprets the staining pattern and reports the findings. Common settings include evaluation of renal biopsy tissue for immune deposits and direct immunofluorescence studies of skin biopsies when an autoimmune blistering disorder is suspected. Laboratory staff prepare and stain the tissue; the pathologist provides the diagnostic interpretation.
Report 88350 for each additional single-antibody stain after the first stain reported with 88346. The record should identify the tissue studied, the antibodies tested, and the results supporting each stain. This is an add-on code, so it is billed with its primary procedure and paid within that procedure’s global period. Modifier 26 identifies the professional interpretation, while modifier TC identifies the technical work, equipment, and staff; reporting without either modifier represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How South Dakota compares for 88350
Across 109 of 109 payment localities, the office rate for 88350 runs from $94.31 in Arkansas to $147.09 in San Benito County, CA. South Dakota pays $106.44. The RVUs are the same everywhere; the geographic indexes change the dollars.
- South Dakota · this page$106.44
- Los Angeles, CA · California$123.34+$16.90
- Washington, DC area · District of Columbia$123.46+$17.02
- Miami, FL · Florida$111.46+$5.02
- Chicago, IL · Illinois$108.32+$1.88
- Manhattan, NY · New York$122.58+$16.14
- Alaska · Alaska$121.91+$15.47
Other areas in South Dakota first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $95.74 | — |
| ArkansasArkansas | $94.31 | — |
| ArizonaArizona | $104.09 | — |
| Bakersfield, CACalifornia | $115.33 | — |
| Chico, CACalifornia | $115.24 | — |
| El Centro, CACalifornia | $115.24 | — |
| Fresno, CACalifornia | $115.24 | — |
| Hanford, CACalifornia | $115.24 | — |
| Madera, CACalifornia | $115.24 | — |
| Merced, CACalifornia | $115.24 | — |
| Modesto, CACalifornia | $115.24 | — |
| Napa, CACalifornia | $135.39 | — |
| Oxnard, CACalifornia | $122.98 | — |
| Redding, CACalifornia | $115.24 | — |
| Rest of CaliforniaCalifornia | $115.24 | — |
| Riverside, CACalifornia | $115.47 | — |
| Sacramento, CACalifornia | $121.43 | — |
| Salinas, CACalifornia | $120.98 | — |
| San Diego, CACalifornia | $124.18 | — |
| Marin County, CACalifornia | $143.97 | — |
| San Francisco, CACalifornia | $143.94 | — |
| San Benito County, CACalifornia | $147.09 | — |
| Santa Clara County, CACalifornia | $147.00 | — |
| San Luis Obispo, CACalifornia | $118.97 | — |
| Santa Cruz, CACalifornia | $125.65 | — |
| Santa Maria, CACalifornia | $121.53 | — |
| Santa Rosa, CACalifornia | $126.95 | — |
| Stockton, CACalifornia | $115.24 | — |
| Vallejo, CACalifornia | $135.36 | — |
| Visalia, CACalifornia | $115.24 | — |
| Yuba City, CACalifornia | $115.24 | — |
| ColoradoColorado | $112.53 | — |
| ConnecticutConnecticut | $114.10 | — |
| DelawareDelaware | $105.87 | — |
| Fort Lauderdale, FLFlorida | $108.55 | — |
| Rest of FloridaFlorida | $103.40 | — |
| Atlanta, GAGeorgia | $108.46 | — |
| Rest of GeorgiaGeorgia | $97.63 | — |
| Hawaii, Guam, HIHawaii | $118.50 | — |
| IowaIowa | $99.10 | — |
| IdahoIdaho | $99.58 | — |
| East St. Louis, ILIllinois | $100.61 | — |
| Rest of IllinoisIllinois | $99.70 | — |
| Suburban Chicago, ILIllinois | $109.88 | — |
| IndianaIndiana | $100.20 | — |
| KansasKansas | $98.21 | — |
| KentuckyKentucky | $97.19 | — |
| New Orleans, LALouisiana | $101.85 | — |
| Rest of LouisianaLouisiana | $96.87 | — |
| Metropolitan Boston, MAMassachusetts | $124.45 | — |
| Rest of MassachusettsMassachusetts | $111.66 | — |
| Baltimore area, MDMaryland | $113.69 | — |
| Rest of MarylandMaryland | $108.06 | — |
| Rest of MaineMaine | $99.68 | — |
| Southern Maine, MEMaine | $105.85 | — |
| Detroit, MIMichigan | $104.30 | — |
| Rest of MichiganMichigan | $99.41 | — |
| MinnesotaMinnesota | $108.93 | — |
| Metropolitan Kansas City, MOMissouri | $101.57 | — |
| Metropolitan St. Louis, MOMissouri | $102.72 | — |
| Rest of MissouriMissouri | $94.88 | — |
| MississippiMississippi | $94.64 | — |
| MontanaMontana | $106.88 | — |
| North CarolinaNorth Carolina | $100.82 | — |
| North DakotaNorth Dakota | $106.49 | — |
| NebraskaNebraska | $99.78 | — |
| New HampshireNew Hampshire | $110.36 | — |
| Northern New JerseyNew Jersey | $122.04 | — |
| Rest of New JerseyNew Jersey | $115.71 | — |
| New MexicoNew Mexico | $99.81 | — |
| NevadaNevada | $106.86 | — |
| NYC suburbs and Long Island, NYNew York | $125.11 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $116.14 | — |
| Queens, NYNew York | $124.22 | — |
| Rest of New YorkNew York | $102.34 | — |
| OhioOhio | $99.33 | — |
| OklahomaOklahoma | $97.44 | — |
| Portland, OROregon | $116.66 | — |
| Rest of OregonOregon | $106.34 | — |
| Metropolitan Philadelphia, PAPennsylvania | $110.92 | — |
| Rest of PennsylvaniaPennsylvania | $99.73 | — |
| Puerto RicoPuerto Rico | $107.83 | — |
| Rhode IslandRhode Island | $110.04 | — |
| South CarolinaSouth Carolina | $100.18 | — |
| TennesseeTennessee | $98.67 | — |
| Austin, TXTexas | $111.88 | — |
| Beaumont, TXTexas | $99.02 | — |
| Brazoria, TXTexas | $106.11 | — |
| Dallas, TXTexas | $106.62 | — |
| Fort Worth, TXTexas | $105.76 | — |
| Galveston, TXTexas | $106.32 | — |
| Houston, TXTexas | $106.68 | — |
| Rest of TexasTexas | $102.39 | — |
| UtahUtah | $101.60 | — |
| VirginiaVirginia | $105.21 | — |
| Virgin Islands, VIUnited States Virgin Islands | $107.83 | — |
| VermontVermont | $105.68 | — |
| Rest of WashingtonWashington | $111.58 | — |
| King County, WAWashington | $127.44 | — |
| WisconsinWisconsin | $102.77 | — |
| West VirginiaWest Virginia | $95.79 | — |
| WyomingWyoming | $106.71 | — |
88350 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$94.31
$131.17
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $121.91 | 1 |
| AL | $95.74 | 1 |
| AR | $94.31 | 1 |
| AZ | $104.09 | 1 |
| CA | $115.24–$147.09 | 29 |
| CO | $112.53 | 1 |
| CT | $114.10 | 1 |
| DC | $123.46 | 1 |
| DE | $105.87 | 1 |
| FL | $103.40–$111.46 | 3 |
| GA | $97.63–$108.46 | 2 |
| GU | $118.50 | 1 |
| HI | $118.50 | 1 |
| IA | $99.10 | 1 |
| ID | $99.58 | 1 |
| IL | $99.70–$109.88 | 4 |
| IN | $100.20 | 1 |
| KS | $98.21 | 1 |
| KY | $97.19 | 1 |
| LA | $96.87–$101.85 | 2 |
| MA | $111.66–$124.45 | 2 |
| MD | $108.06–$123.46 | 3 |
| ME | $99.68–$105.85 | 2 |
| MI | $99.41–$104.30 | 2 |
| MN | $108.93 | 1 |
| MO | $94.88–$102.72 | 3 |
| MS | $94.64 | 1 |
| MT | $106.88 | 1 |
| NC | $100.82 | 1 |
| ND | $106.49 | 1 |
| NE | $99.78 | 1 |
| NH | $110.36 | 1 |
| NJ | $115.71–$122.04 | 2 |
| NM | $99.81 | 1 |
| NV | $106.86 | 1 |
| NY | $102.34–$125.11 | 5 |
| OH | $99.33 | 1 |
| OK | $97.44 | 1 |
| OR | $106.34–$116.66 | 2 |
| PA | $99.73–$110.92 | 2 |
| PR | $107.83 | 1 |
| RI | $110.04 | 1 |
| SC | $100.18 | 1 |
| SD | $106.44 | 1 |
| TN | $98.67 | 1 |
| TX | $99.02–$111.88 | 8 |
| UT | $101.60 | 1 |
| VA | $105.21–$123.46 | 2 |
| VI | $107.83 | 1 |
| VT | $105.68 | 1 |
| WA | $111.58–$127.44 | 2 |
| WI | $102.77 | 1 |
| WV | $95.79 | 1 |
| WY | $106.71 | 1 |
How the 88350 rate is calculated
Each of 88350’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88350
RVUs × geographic indexes × conversion factor
Work0.58
0.58 RVUs× 1.000 GPCI
Practice expense2.60
2.60 RVUs× 1.000 GPCI
Malpractice0.02
0.02 RVUs× 1.000 GPCI
Adjusted RVUs
3.2000
Conversion factor
$33.4009
Medicare rate
$106.88
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact South Dakota inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,263
- Code
- 88350
- Physician work
- 0.58
- Practice expense
- 2.60
- Malpractice
- 0.02
GPCI2026.csv
94
- Locality
- South Dakota
- Physician work
- 1.000
- Practice expense
- 1.000
- Malpractice
- 0.336
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.58 | × 1.000 | 0.5800 |
| Practice expense | 2.60 | × 1.000 | 2.6000 |
| Malpractice | 0.02 | × 0.336 | 0.0067 |
| Total RVUs | 3.1867 | ||
| Conversion factor | × 33.4009 | ||
Office rate, South Dakota$106.44
Office: (0.58 × 1 + 2.6 × 1 + 0.02 × 0.336) × $33.4009 = $106.44
Payment rules and modifiers for 88350
The CMS indicators that decide how 88350 is paid alongside other services.
CMS payment indicators · 88350
Immunofluorescence, each additional antibody stain
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88350 without 26 · national office
$106.88
Immunofluorescence, each additional antibody stain
88350-26 · Professional component
$27.39
Pays only the interpretation and report.
How 88350 has changed in South Dakota
88350 · Office / nonfacility
$106.44
Effective 2026-10-01
The base rate is $0.23 lower than on 2025-10-01, moving from $106.67 to $106.44 (0.2%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$106.67changed to$106.44
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.59 changed to 0.58
- Practice expense RVU 2.70 changed to 2.60
- Malpractice GPCI 0.382 changed to 0.336
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$113.43changed to$106.67
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 2.81 changed to 2.70
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$111.58changed to$113.43
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$117.16changed to$111.58
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 2.86 changed to 2.81
- Malpractice GPCI 0.364 changed to 0.382
January 1, 2023
RVU23A
$119.63changed to$117.16
- Conversion factor 34.6062 changed to 33.8872
- Malpractice GPCI 0.347 changed to 0.364
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$110.16changed to$119.63
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 2.56 changed to 2.86
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$93.74changed to$110.16
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 2.00 changed to 2.56
- Malpractice GPCI 0.368 changed to 0.347
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$78.35changed to$93.74
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 1.58 changed to 2.00
- Malpractice RVU 0.01 changed to 0.02
- Malpractice GPCI 0.389 changed to 0.368
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$73.58changed to$78.35
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 1.45 changed to 1.58
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$74.07changed to$73.58
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 1.47 changed to 1.45
- Malpractice GPCI 0.395 changed to 0.389
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$72.11changed to$74.07
- Conversion factor 35.8043 changed to 35.8887
- Work RVU 0.56 changed to 0.59
- Practice expense RVU 1.45 changed to 1.47
- Malpractice GPCI 0.400 changed to 0.395
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
No ratechanged to$72.11
Held through RVU16B, RVU16C, RVU16D.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D, RVU15A, RVU15B, RVU15C, RVU15D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $106.44 | Not available in this setting | RVU26D |
| 2026-07-01 | $106.44 | Not available in this setting | RVU26C |
| 2026-04-01 | $106.44 | Not available in this setting | RVU26B |
| 2026-01-01 | $106.44 | Not available in this setting | RVU26A |
| 2025-10-01 | $106.67 | Not available in this setting | RVU25D |
| 2025-07-01 | $106.67 | Not available in this setting | RVU25C |
| 2025-04-01 | $106.67 | Not available in this setting | RVU25B |
| 2025-01-01 | $106.67 | Not available in this setting | RVU25A |
| 2024-10-01 | $113.43 | Not available in this setting | RVU24D |
| 2024-07-01 | $113.43 | Not available in this setting | RVU24C |
| 2024-04-01 | $113.43 | Not available in this setting | RVU24B |
| 2024-03-09 | $113.43 | Not available in this setting | RVU24AR |
| 2024-01-01 | $111.58 | Not available in this setting | RVU24A |
| 2023-10-01 | $117.16 | Not available in this setting | RVU23D |
| 2023-07-01 | $117.16 | Not available in this setting | RVU23C |
| 2023-04-01 | $117.16 | Not available in this setting | RVU23B |
| 2023-01-01 | $117.16 | Not available in this setting | RVU23A |
| 2022-10-01 | $119.63 | Not available in this setting | RVU22D |
| 2022-07-01 | $119.63 | Not available in this setting | RVU22C |
| 2022-04-01 | $119.63 | Not available in this setting | RVU22B |
| 2022-01-01 | $119.63 | Not available in this setting | RVU22A |
| 2021-10-01 | $110.16 | Not available in this setting | RVU21D |
| 2021-07-01 | $110.16 | Not available in this setting | RVU21C |
| 2021-04-01 | $110.16 | Not available in this setting | RVU21B |
| 2021-01-01 | $110.16 | Not available in this setting | RVU21A |
| 2020-10-01 | $93.74 | Not available in this setting | RVU20D |
| 2020-07-01 | $93.74 | Not available in this setting | RVU20C |
| 2020-04-01 | $93.74 | Not available in this setting | RVU20B |
| 2020-01-01 | $93.74 | Not available in this setting | RVU20A |
| 2019-10-01 | $78.35 | Not available in this setting | RVU19D |
| 2019-07-01 | $78.35 | Not available in this setting | RVU19C |
| 2019-04-01 | $78.35 | Not available in this setting | RVU19B |
| 2019-01-01 | $78.35 | Not available in this setting | RVU19A |
| 2018-10-01 | $73.58 | Not available in this setting | RVU18D |
| 2018-07-01 | $73.58 | Not available in this setting | RVU18C |
| 2018-04-01 | $73.58 | Not available in this setting | RVU18B |
| 2018-01-01 | $73.58 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $74.07 | Not available in this setting | RVU17D |
| 2017-07-01 | $74.07 | Not available in this setting | RVU17C |
| 2017-04-01 | $74.07 | Not available in this setting | RVU17B |
| 2017-01-01 | $74.07 | Not available in this setting | RVU17A |
| 2016-10-01 | $72.11 | Not available in this setting | RVU16D |
| 2016-07-01 | $72.11 | Not available in this setting | RVU16C |
| 2016-04-01 | $72.11 | Not available in this setting | RVU16B |
| 2016-01-01 | $72.11 | Not available in this setting | RVU16A |
| 2015-10-01 | Not in this release | Not in this release | RVU15D |
| 2015-07-01 | Not in this release | Not in this release | RVU15C |
| 2015-04-01 | Not in this release | Not in this release | RVU15B |
| 2015-01-01 | Not in this release | Not in this release | RVU15A |
| 2014-10-01 | Not in this release | Not in this release | RVU14D |
| 2014-07-01 | Not in this release | Not in this release | RVU14C |
| 2014-04-01 | Not in this release | Not in this release | RVU14B |
| 2014-01-01 | Not in this release | Not in this release | RVU14A |
| 2013-10-01 | Not in this release | Not in this release | RVU13D |
| 2013-07-01 | Not in this release | Not in this release | RVU13C |
| 2013-04-01 | Not in this release | Not in this release | RVU13B |
| 2013-01-01 | Not in this release | Not in this release | RVU13AR |
Where the South Dakota rate applies
South Dakota is a Medicare payment area, not a city. Our Census mapping connects it to 485 cities and communities in South Dakota. Some span more than one payment area; confirm with the service ZIP.
- Aberdeen
- Agar
- Agency Village
- Akaska
- Albee
- Alcester
- Alexandria
- Allen
88350 billing questions
Can 88350 be reported by itself?
No. It is an add-on for additional immunofluorescence stains and is reported with the primary stain code, 88346.
How does 88350 differ from 88346?
88346 represents the first single-antibody immunofluorescence stain. Use 88350 for each additional single-antibody stain in the same service.
When should the laboratory use an immunohistochemistry code instead?
Use the immunohistochemistry or immunocytochemistry code family when the laboratory performs that staining method rather than immunofluorescence. The documented method, not simply the antibody being tested, distinguishes the service.
Can the professional and technical portions be billed separately?
Yes. Modifier 26 identifies the pathologist’s professional interpretation, and modifier TC identifies the technical portion. Without either modifier, the claim represents the global service.
What documentation supports additional units?
Document the tissue examined and each additional antibody stain performed, with findings supporting the interpretation. Report 88350 with 88346 rather than as a standalone service.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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