CPT code 88367: ISH analysis, automated morphometric analysis2026 Medicare rate & RVUs

Medicare pays $104.88 for 88367 nationally in the office. Local office rates run $93.20–$142.76.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What 88367 covers

This service covers automated morphometric analysis of in situ hybridization signals in a tissue specimen. A pathology laboratory uses imaging equipment and software to assess signal patterns, while a pathologist interprets the findings in the clinical and morphologic context. A familiar application is evaluating HER2 gene amplification in tumor tissue, including breast or gastric specimens, when the assay and analysis method support this code. It represents image-based analysis, not simply the preparation or staining of a probe slide.

Select the code based on the documented analysis method and the applicable CPT distinction between automated and manual analysis. The record should support the specimen analyzed, the in situ hybridization method, the automated analysis performed, and the pathologist’s interpretation. CMS recognizes professional and technical components: report modifier 26 for the interpretation, modifier TC for the equipment and staff, or neither modifier when billing the global service. The CMS fee schedule prices modifiers 26 and TC separately.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where 88367 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

88367 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the 88367 rate is calculated

Each of 88367’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for 88367

The CMS indicators that decide how 88367 is paid alongside other services.

What modifiers do to the payment

When to use modifier 26

88367 compared with similar codes

How to choose

88368ISH analysisManual, initial probe

88368 is the manual morphometric analysis counterpart; 88367 is used when the analysis is automated.

88369ISH morphometryQuantitative or semiquantitative

88369 describes manual quantitative or semiquantitative morphometric analysis, rather than the automated analysis represented by 88367.

88373ISH analysisComputer-assisted morphometry

88373 is for automated quantitative or semiquantitative morphometric analysis; 88367 is the automated morphometric analysis code without that specific quantitative or semiquantitative distinction.

88364ISH probe stainEach additional probe

88364 represents the initial single-probe in situ hybridization stain procedure, not automated morphometric analysis of the resulting signals.

Codes related to 88367

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates