CPT code 88374: ISH analysis, computer-assisted morphometry2026 Medicare rate & RVUs

Medicare pays $266.21 for 88374 nationally in the office. Local office rates run $232.73–$373.17.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What 88374 covers

A pathology laboratory uses image-analysis technology to quantify or semiquantify in situ hybridization signals in a tissue specimen. The analysis supports interpretation of molecular markers visible in cells or tissue, such as gene-copy patterns assessed in a tumor biopsy. A pathologist reviews the findings and incorporates them into the diagnostic workup; the technical work is generally performed by laboratory staff using specialized imaging equipment.

Select this service when the requested work is morphometric analysis of an in situ hybridization assay using computer-assisted technology, rather than manual measurement or tumor immunohistochemistry analysis. The record should identify the specimen, the assay and target, the quantitative or semiquantitative analysis performed, and the resulting interpretation. CMS recognizes separately priced professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the equipment-and-staff portion, and reporting without either modifier represents the global service.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where 88374 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

88374 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the 88374 rate is calculated

Each of 88374’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for 88374

The CMS indicators that decide how 88374 is paid alongside other services.

What modifiers do to the payment

When to use modifier 26

88374 compared with similar codes

How to choose

88373ISH analysisComputer-assisted morphometry

88373 represents manual ISH morphometric analysis. This code is for the computer-assisted method.

88360Tumor IHC scoringManual quantitative, per antibody

88360 concerns morphometric analysis of tumor immunohistochemistry using a manual method. This code concerns ISH findings analyzed with computer assistance.

88361Tumor immunohistochemistryComputer-assisted analysis

88361 is computer-assisted morphometric analysis of tumor immunohistochemistry; this code is for computer-assisted morphometric analysis of ISH.

Codes related to 88374

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates