CPT code 88374: ISH analysis, computer-assisted morphometry2026 Medicare rate & RVUs in South Dakota

In South Dakota, Medicare pays $265.76 for 88374 in the office.

Check a contract rate as a % of Medicare · 88374 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What 88374 covers

A pathology laboratory uses image-analysis technology to quantify or semiquantify in situ hybridization signals in a tissue specimen. The analysis supports interpretation of molecular markers visible in cells or tissue, such as gene-copy patterns assessed in a tumor biopsy. A pathologist reviews the findings and incorporates them into the diagnostic workup; the technical work is generally performed by laboratory staff using specialized imaging equipment.

Select this service when the requested work is morphometric analysis of an in situ hybridization assay using computer-assisted technology, rather than manual measurement or tumor immunohistochemistry analysis. The record should identify the specimen, the assay and target, the quantitative or semiquantitative analysis performed, and the resulting interpretation. CMS recognizes separately priced professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the equipment-and-staff portion, and reporting without either modifier represents the global service.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How South Dakota compares for 88374

Across 109 of 109 payment localities, the office rate for 88374 runs from $232.73 in Arkansas to $373.17 in San Benito County, CA. South Dakota pays $265.76. The RVUs are the same everywhere; the geographic indexes change the dollars.

Every other payment area

88374 rates by state

Office rate range in each state. Select a state to see its payment localities.

See 88374 in every payment locality

How the 88374 rate is calculated

Each of 88374’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for 88374

The CMS indicators that decide how 88374 is paid alongside other services.

What modifiers do to the payment

When to use modifier 26

Codes related to 88374

Related codes aren’t interchangeable: bill the code that matches the service performed.

How 88374 has changed in South Dakota

Price 88374 for an earlier date of service

Where the South Dakota rate applies

South Dakota is a Medicare payment area, not a city. Our Census mapping connects it to 485 cities and communities in South Dakota. Some span more than one payment area; confirm with the service ZIP.

• Aberdeen
• Agar
• Agency Village
• Akaska
• Albee
• Alcester
• Alexandria
• Allen

Browse all communities in South Dakota

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates