CPT code 88374: ISH analysis, computer-assisted morphometry2026 Medicare rate & RVUs in Vermont
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings in a tissue specimen.
In Vermont, Medicare pays $263.52 for 88374 in the office.
Check a contract rate as a % of Medicare · 88374 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88374 covers
A pathology laboratory uses image-analysis technology to quantify or semiquantify in situ hybridization signals in a tissue specimen. The analysis supports interpretation of molecular markers visible in cells or tissue, such as gene-copy patterns assessed in a tumor biopsy. A pathologist reviews the findings and incorporates them into the diagnostic workup; the technical work is generally performed by laboratory staff using specialized imaging equipment.
Select this service when the requested work is morphometric analysis of an in situ hybridization assay using computer-assisted technology, rather than manual measurement or tumor immunohistochemistry analysis. The record should identify the specimen, the assay and target, the quantitative or semiquantitative analysis performed, and the resulting interpretation. CMS recognizes separately priced professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the equipment-and-staff portion, and reporting without either modifier represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Vermont compares for 88374
Across 109 of 109 payment localities, the office rate for 88374 runs from $232.73 in Arkansas to $373.17 in San Benito County, CA. Vermont pays $263.52. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Vermont · this page$263.52
- Los Angeles, CA · California$310.26+$46.74
- Washington, DC area · District of Columbia$309.78+$46.26
- Miami, FL · Florida$276.87+$13.35
- Chicago, IL · Illinois$268.46+$4.94
- Manhattan, NY · New York$306.63+$43.11
- Alaska · Alaska$296.39+$32.87
Other areas in Vermont first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $236.52 | — |
| ArkansasArkansas | $232.73 | — |
| ArizonaArizona | $258.82 | — |
| Bakersfield, CACalifornia | $289.10 | — |
| Chico, CACalifornia | $288.99 | — |
| El Centro, CACalifornia | $288.99 | — |
| Fresno, CACalifornia | $288.99 | — |
| Hanford, CACalifornia | $288.99 | — |
| Madera, CACalifornia | $288.99 | — |
| Merced, CACalifornia | $288.99 | — |
| Modesto, CACalifornia | $288.99 | — |
| Napa, CACalifornia | $342.57 | — |
| Oxnard, CACalifornia | $309.60 | — |
| Redding, CACalifornia | $288.99 | — |
| Rest of CaliforniaCalifornia | $288.99 | — |
| Riverside, CACalifornia | $289.23 | — |
| Sacramento, CACalifornia | $305.32 | — |
| Salinas, CACalifornia | $304.23 | — |
| San Diego, CACalifornia | $312.90 | — |
| Marin County, CACalifornia | $365.14 | — |
| San Francisco, CACalifornia | $365.12 | — |
| San Benito County, CACalifornia | $373.17 | — |
| Santa Clara County, CACalifornia | $373.08 | — |
| San Luis Obispo, CACalifornia | $299.10 | — |
| Santa Cruz, CACalifornia | $317.09 | — |
| Santa Maria, CACalifornia | $305.78 | — |
| Santa Rosa, CACalifornia | $320.42 | — |
| Stockton, CACalifornia | $288.99 | — |
| Vallejo, CACalifornia | $342.53 | — |
| Visalia, CACalifornia | $288.99 | — |
| Yuba City, CACalifornia | $288.99 | — |
| ColoradoColorado | $281.47 | — |
| ConnecticutConnecticut | $285.06 | — |
| DelawareDelaware | $263.47 | — |
| Fort Lauderdale, FLFlorida | $269.80 | — |
| Rest of FloridaFlorida | $256.19 | — |
| Atlanta, GAGeorgia | $270.19 | — |
| Rest of GeorgiaGeorgia | $240.94 | — |
| Hawaii, Guam, HIHawaii | $298.14 | — |
| IowaIowa | $245.82 | — |
| IdahoIdaho | $247.04 | — |
| East St. Louis, ILIllinois | $248.07 | — |
| Rest of IllinoisIllinois | $246.12 | — |
| Suburban Chicago, ILIllinois | $273.28 | — |
| IndianaIndiana | $248.70 | — |
| KansasKansas | $243.30 | — |
| KentuckyKentucky | $240.05 | — |
| New Orleans, LALouisiana | $252.42 | — |
| Rest of LouisianaLouisiana | $239.14 | — |
| Metropolitan Boston, MAMassachusetts | $313.00 | — |
| Rest of MassachusettsMassachusetts | $279.02 | — |
| Baltimore area, MDMaryland | $284.02 | — |
| Rest of MarylandMaryland | $269.28 | — |
| Rest of MaineMaine | $247.14 | — |
| Southern Maine, MEMaine | $263.84 | — |
| Detroit, MIMichigan | $258.43 | — |
| Rest of MichiganMichigan | $245.83 | — |
| MinnesotaMinnesota | $272.55 | — |
| Metropolitan Kansas City, MOMissouri | $251.85 | — |
| Metropolitan St. Louis, MOMissouri | $254.92 | — |
| Rest of MissouriMissouri | $233.74 | — |
| MississippiMississippi | $233.35 | — |
| MontanaMontana | $266.20 | — |
| North CarolinaNorth Carolina | $250.21 | — |
| North DakotaNorth Dakota | $265.81 | — |
| NebraskaNebraska | $247.68 | — |
| New HampshireNew Hampshire | $275.76 | — |
| Northern New JerseyNew Jersey | $305.79 | — |
| Rest of New JerseyNew Jersey | $289.12 | — |
| New MexicoNew Mexico | $246.82 | — |
| NevadaNevada | $266.33 | — |
| NYC suburbs and Long Island, NYNew York | $313.16 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $290.05 | — |
| Queens, NYNew York | $311.24 | — |
| Rest of New YorkNew York | $254.25 | — |
| OhioOhio | $245.75 | — |
| OklahomaOklahoma | $240.90 | — |
| Portland, OROregon | $292.62 | — |
| Rest of OregonOregon | $265.07 | — |
| Metropolitan Philadelphia, PAPennsylvania | $276.52 | — |
| Rest of PennsylvaniaPennsylvania | $246.89 | — |
| Puerto RicoPuerto Rico | $268.78 | — |
| Rhode IslandRhode Island | $274.47 | — |
| South CarolinaSouth Carolina | $248.23 | — |
| South DakotaSouth Dakota | $265.76 | — |
| TennesseeTennessee | $244.50 | — |
| Austin, TXTexas | $279.83 | — |
| Beaumont, TXTexas | $244.99 | — |
| Brazoria, TXTexas | $264.19 | — |
| Dallas, TXTexas | $265.44 | — |
| Fort Worth, TXTexas | $263.10 | — |
| Galveston, TXTexas | $264.69 | — |
| Houston, TXTexas | $265.05 | — |
| Rest of TexasTexas | $254.15 | — |
| UtahUtah | $252.03 | — |
| VirginiaVirginia | $262.01 | — |
| Virgin Islands, VIUnited States Virgin Islands | $268.78 | — |
| Rest of WashingtonWashington | $278.90 | — |
| King County, WAWashington | $320.98 | — |
| WisconsinWisconsin | $255.87 | — |
| West VirginiaWest Virginia | $235.69 | — |
| WyomingWyoming | $266.03 | — |
88374 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$232.73
$331.08
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $296.39 | 1 |
| AL | $236.52 | 1 |
| AR | $232.73 | 1 |
| AZ | $258.82 | 1 |
| CA | $288.99–$373.17 | 29 |
| CO | $281.47 | 1 |
| CT | $285.06 | 1 |
| DC | $309.78 | 1 |
| DE | $263.47 | 1 |
| FL | $256.19–$276.87 | 3 |
| GA | $240.94–$270.19 | 2 |
| GU | $298.14 | 1 |
| HI | $298.14 | 1 |
| IA | $245.82 | 1 |
| ID | $247.04 | 1 |
| IL | $246.12–$273.28 | 4 |
| IN | $248.70 | 1 |
| KS | $243.30 | 1 |
| KY | $240.05 | 1 |
| LA | $239.14–$252.42 | 2 |
| MA | $279.02–$313.00 | 2 |
| MD | $269.28–$309.78 | 3 |
| ME | $247.14–$263.84 | 2 |
| MI | $245.83–$258.43 | 2 |
| MN | $272.55 | 1 |
| MO | $233.74–$254.92 | 3 |
| MS | $233.35 | 1 |
| MT | $266.20 | 1 |
| NC | $250.21 | 1 |
| ND | $265.81 | 1 |
| NE | $247.68 | 1 |
| NH | $275.76 | 1 |
| NJ | $289.12–$305.79 | 2 |
| NM | $246.82 | 1 |
| NV | $266.33 | 1 |
| NY | $254.25–$313.16 | 5 |
| OH | $245.75 | 1 |
| OK | $240.90 | 1 |
| OR | $265.07–$292.62 | 2 |
| PA | $246.89–$276.52 | 2 |
| PR | $268.78 | 1 |
| RI | $274.47 | 1 |
| SC | $248.23 | 1 |
| SD | $265.76 | 1 |
| TN | $244.50 | 1 |
| TX | $244.99–$279.83 | 8 |
| UT | $252.03 | 1 |
| VA | $262.01–$309.78 | 2 |
| VI | $268.78 | 1 |
| VT | $263.52 | 1 |
| WA | $278.90–$320.98 | 2 |
| WI | $255.87 | 1 |
| WV | $235.69 | 1 |
| WY | $266.03 | 1 |
How the 88374 rate is calculated
Each of 88374’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88374
RVUs × geographic indexes × conversion factor
Work0.91
0.91 RVUs× 1.000 GPCI
Practice expense7.04
7.04 RVUs× 1.000 GPCI
Malpractice0.02
0.02 RVUs× 1.000 GPCI
Adjusted RVUs
7.9700
Conversion factor
$33.4009
Medicare rate
$266.21
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Vermont inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,310
- Code
- 88374
- Physician work
- 0.91
- Practice expense
- 7.04
- Malpractice
- 0.02
GPCI2026.csv
105
- Locality
- Vermont
- Physician work
- 1.000
- Practice expense
- 0.990
- Malpractice
- 0.506
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.91 | × 1.000 | 0.9100 |
| Practice expense | 7.04 | × 0.990 | 6.9696 |
| Malpractice | 0.02 | × 0.506 | 0.0101 |
| Total RVUs | 7.8897 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Vermont$263.52
Office: (0.91 × 1 + 7.04 × 0.99 + 0.02 × 0.506) × $33.4009 = $263.52
Payment rules and modifiers for 88374
The CMS indicators that decide how 88374 is paid alongside other services.
CMS payment indicators · 88374
ISH analysis, computer-assisted morphometry
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88374 without 26 · national office
$266.21
ISH analysis, computer-assisted morphometry
88374-26 · Professional component
$39.41
Pays only the interpretation and report.
How 88374 has changed in Vermont
88374 · Office / nonfacility
$263.52
Effective 2026-10-01
The base rate is $1.35 higher than on 2025-10-01, moving from $262.17 to $263.52 (0.5%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$262.17changed to$263.52
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.93 changed to 0.91
- Practice expense RVU 7.21 changed to 7.04
- Malpractice RVU 0.03 changed to 0.02
- Practice expense GPCI 0.993 changed to 0.990
- Malpractice GPCI 0.518 changed to 0.506
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$285.16changed to$262.17
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 7.68 changed to 7.21
- Malpractice RVU 0.02 changed to 0.03
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$280.51changed to$285.16
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$305.21changed to$280.51
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 8.09 changed to 7.68
- Practice expense GPCI 0.997 changed to 0.993
- Malpractice GPCI 0.543 changed to 0.518
January 1, 2023
RVU23A
$331.87changed to$305.21
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 8.64 changed to 8.09
- Practice expense GPCI 1.001 changed to 0.997
- Malpractice GPCI 0.569 changed to 0.543
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$352.44changed to$331.87
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 9.15 changed to 8.64
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$350.47changed to$352.44
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 8.70 changed to 9.15
- Practice expense GPCI 1.008 changed to 1.001
- Malpractice GPCI 0.582 changed to 0.569
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$335.00changed to$350.47
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 8.23 changed to 8.70
- Practice expense GPCI 1.015 changed to 1.008
- Malpractice GPCI 0.595 changed to 0.582
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$355.82changed to$335.00
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 8.81 changed to 8.23
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$346.16changed to$355.82
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 8.61 changed to 8.81
- Malpractice RVU 0.03 changed to 0.02
- Practice expense GPCI 1.010 changed to 1.015
- Malpractice GPCI 0.639 changed to 0.595
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$346.77changed to$346.16
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 8.70 changed to 8.61
- Practice expense GPCI 1.004 changed to 1.010
- Malpractice GPCI 0.682 changed to 0.639
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$206.00changed to$346.77
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 4.77 changed to 8.70
- Malpractice RVU 0.02 changed to 0.03
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$204.97changed to$206.00
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
No ratechanged to$204.97
Held through RVU15B.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $263.52 | Not available in this setting | RVU26D |
| 2026-07-01 | $263.52 | Not available in this setting | RVU26C |
| 2026-04-01 | $263.52 | Not available in this setting | RVU26B |
| 2026-01-01 | $263.52 | Not available in this setting | RVU26A |
| 2025-10-01 | $262.17 | Not available in this setting | RVU25D |
| 2025-07-01 | $262.17 | Not available in this setting | RVU25C |
| 2025-04-01 | $262.17 | Not available in this setting | RVU25B |
| 2025-01-01 | $262.17 | Not available in this setting | RVU25A |
| 2024-10-01 | $285.16 | Not available in this setting | RVU24D |
| 2024-07-01 | $285.16 | Not available in this setting | RVU24C |
| 2024-04-01 | $285.16 | Not available in this setting | RVU24B |
| 2024-03-09 | $285.16 | Not available in this setting | RVU24AR |
| 2024-01-01 | $280.51 | Not available in this setting | RVU24A |
| 2023-10-01 | $305.21 | Not available in this setting | RVU23D |
| 2023-07-01 | $305.21 | Not available in this setting | RVU23C |
| 2023-04-01 | $305.21 | Not available in this setting | RVU23B |
| 2023-01-01 | $305.21 | Not available in this setting | RVU23A |
| 2022-10-01 | $331.87 | Not available in this setting | RVU22D |
| 2022-07-01 | $331.87 | Not available in this setting | RVU22C |
| 2022-04-01 | $331.87 | Not available in this setting | RVU22B |
| 2022-01-01 | $331.87 | Not available in this setting | RVU22A |
| 2021-10-01 | $352.44 | Not available in this setting | RVU21D |
| 2021-07-01 | $352.44 | Not available in this setting | RVU21C |
| 2021-04-01 | $352.44 | Not available in this setting | RVU21B |
| 2021-01-01 | $352.44 | Not available in this setting | RVU21A |
| 2020-10-01 | $350.47 | Not available in this setting | RVU20D |
| 2020-07-01 | $350.47 | Not available in this setting | RVU20C |
| 2020-04-01 | $350.47 | Not available in this setting | RVU20B |
| 2020-01-01 | $350.47 | Not available in this setting | RVU20A |
| 2019-10-01 | $335.00 | Not available in this setting | RVU19D |
| 2019-07-01 | $335.00 | Not available in this setting | RVU19C |
| 2019-04-01 | $335.00 | Not available in this setting | RVU19B |
| 2019-01-01 | $335.00 | Not available in this setting | RVU19A |
| 2018-10-01 | $355.82 | Not available in this setting | RVU18D |
| 2018-07-01 | $355.82 | Not available in this setting | RVU18C |
| 2018-04-01 | $355.82 | Not available in this setting | RVU18B |
| 2018-01-01 | $355.82 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $346.16 | Not available in this setting | RVU17D |
| 2017-07-01 | $346.16 | Not available in this setting | RVU17C |
| 2017-04-01 | $346.16 | Not available in this setting | RVU17B |
| 2017-01-01 | $346.16 | Not available in this setting | RVU17A |
| 2016-10-01 | $346.77 | Not available in this setting | RVU16D |
| 2016-07-01 | $346.77 | Not available in this setting | RVU16C |
| 2016-04-01 | $346.77 | Not available in this setting | RVU16B |
| 2016-01-01 | $346.77 | Not available in this setting | RVU16A |
| 2015-10-01 | $206.00 | Not available in this setting | RVU15D |
| 2015-07-01 | $206.00 | Not available in this setting | RVU15C |
| 2015-04-01 | $204.97 | Not available in this setting | RVU15B |
| 2015-01-01 | $204.97 | Not available in this setting | RVU15A |
| 2014-10-01 | Not in this release | Not in this release | RVU14D |
| 2014-07-01 | Not in this release | Not in this release | RVU14C |
| 2014-04-01 | Not in this release | Not in this release | RVU14B |
| 2014-01-01 | Not in this release | Not in this release | RVU14A |
| 2013-10-01 | Not in this release | Not in this release | RVU13D |
| 2013-07-01 | Not in this release | Not in this release | RVU13C |
| 2013-04-01 | Not in this release | Not in this release | RVU13B |
| 2013-01-01 | Not in this release | Not in this release | RVU13AR |
Where the Vermont rate applies
Vermont is a Medicare payment area, not a city. Our Census mapping connects it to 180 cities and communities in Vermont. Some span more than one payment area; confirm with the service ZIP.
- Albany
- Alburgh
- Algiers
- Arlington
- Ascutney
- Bakersfield
- Barnet
- Barre
88374 billing questions
How does this differ from manual ISH morphometric analysis?
This code is for quantitative or semiquantitative ISH morphometric analysis performed with computer-assisted technology. Use the manual counterpart when the morphometric analysis is performed manually.
Is this the same as tumor immunohistochemistry analysis?
No. This service analyzes in situ hybridization findings; tumor immunohistochemistry analysis evaluates immunostaining and is reported with the applicable IHC morphometric-analysis code.
Which modifiers identify the components?
Modifier 26 reports the professional interpretation, and modifier TC reports the technical service, including equipment and staff. Without either modifier, the claim represents the global service.
What documentation supports reporting this service?
Document the specimen and ISH assay, the use of computer-assisted quantitative or semiquantitative morphometric analysis, and the pathologist's interpretation of the findings.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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