CPT code 88375: Optical endomicroscopy, professional component2026 Medicare rate & RVUs in Mississippi
Report this service for a physician’s interpretation and report of real-time or recorded optical endomicroscopy images obtained during microscopic tissue assessment.
In Mississippi, Medicare pays $42.75 for 88375 in the office and $42.75 when it’s performed in a hospital or facility.
Check a contract rate as a % of Medicare · 88375 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88375 covers
Optical endomicroscopy produces microscopic images of tissue in a clinical setting, commonly during gastrointestinal endoscopy. The physician reviews real-time or recorded images to assess cellular and tissue features and prepares an interpretation and report. This is image-based assessment, distinct from examining a removed specimen on a conventional pathology slide.
Report 88375 for the professional interpretation and report, not for acquiring the images or furnishing the equipment and other technical work. CMS identifies this as a professional-component-only code; a separate code covers the technical portion. Documentation should identify the optical endomicroscopy study, the images reviewed, the physician’s findings, and the resulting interpretation. When optical endomicroscopy is performed as part of an endoscopic procedure, the endoscopy code describes that procedure; 88375 represents the separately coded interpretation service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Mississippi compares for 88375
Across 109 of 109 payment localities, the office rate for 88375 runs from $42.35 in Arkansas to $60.09 in Alaska. Mississippi pays $42.75. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Mississippi · this page$42.75
- Los Angeles, CA · California$48.25+$5.50
- Washington, DC area · District of Columbia$49.32+$6.57
- Miami, FL · Florida$48.21+$5.46
- Chicago, IL · Illinois$47.53+$4.78
- Manhattan, NY · New York$50.19+$7.44
- Alaska · Alaska$60.09+$17.34
Other areas in Mississippi first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $42.65 | $42.65 |
| ArkansasArkansas | $42.35 | $42.35 |
| ArizonaArizona | $44.43 | $44.43 |
| Bakersfield, CACalifornia | $46.32 | $46.32 |
| Chico, CACalifornia | $46.14 | $46.14 |
| El Centro, CACalifornia | $46.14 | $46.14 |
| Fresno, CACalifornia | $46.14 | $46.14 |
| Hanford, CACalifornia | $46.14 | $46.14 |
| Madera, CACalifornia | $46.14 | $46.14 |
| Merced, CACalifornia | $46.14 | $46.14 |
| Modesto, CACalifornia | $46.14 | $46.14 |
| Napa, CACalifornia | $50.50 | $50.50 |
| Oxnard, CACalifornia | $47.79 | $47.79 |
| Redding, CACalifornia | $46.14 | $46.14 |
| Rest of CaliforniaCalifornia | $46.14 | $46.14 |
| Riverside, CACalifornia | $46.70 | $46.70 |
| Sacramento, CACalifornia | $47.62 | $47.62 |
| Salinas, CACalifornia | $47.42 | $47.42 |
| San Diego, CACalifornia | $47.90 | $47.90 |
| Marin County, CACalifornia | $52.63 | $52.63 |
| San Francisco, CACalifornia | $52.57 | $52.57 |
| San Benito County, CACalifornia | $53.64 | $53.64 |
| Santa Clara County, CACalifornia | $53.41 | $53.41 |
| San Luis Obispo, CACalifornia | $46.73 | $46.73 |
| Santa Cruz, CACalifornia | $47.88 | $47.88 |
| Santa Maria, CACalifornia | $47.42 | $47.42 |
| Santa Rosa, CACalifornia | $48.33 | $48.33 |
| Stockton, CACalifornia | $46.14 | $46.14 |
| Vallejo, CACalifornia | $50.42 | $50.42 |
| Visalia, CACalifornia | $46.14 | $46.14 |
| Yuba City, CACalifornia | $46.14 | $46.14 |
| ColoradoColorado | $45.96 | $45.96 |
| ConnecticutConnecticut | $47.09 | $47.09 |
| DelawareDelaware | $44.91 | $44.91 |
| Fort Lauderdale, FLFlorida | $46.62 | $46.62 |
| Rest of FloridaFlorida | $45.33 | $45.33 |
| Atlanta, GAGeorgia | $45.74 | $45.74 |
| Rest of GeorgiaGeorgia | $43.93 | $43.93 |
| Hawaii, Guam, HIHawaii | $46.26 | $46.26 |
| IowaIowa | $42.92 | $42.92 |
| IdahoIdaho | $43.12 | $43.12 |
| East St. Louis, ILIllinois | $45.69 | $45.69 |
| Rest of IllinoisIllinois | $44.84 | $44.84 |
| Suburban Chicago, ILIllinois | $46.96 | $46.96 |
| IndianaIndiana | $43.23 | $43.23 |
| KansasKansas | $42.95 | $42.95 |
| KentuckyKentucky | $43.43 | $43.43 |
| New Orleans, LALouisiana | $44.51 | $44.51 |
| Rest of LouisianaLouisiana | $43.45 | $43.45 |
| Metropolitan Boston, MAMassachusetts | $48.78 | $48.78 |
| Rest of MassachusettsMassachusetts | $45.95 | $45.95 |
| Baltimore area, MDMaryland | $46.96 | $46.96 |
| Rest of MarylandMaryland | $45.42 | $45.42 |
| Rest of MaineMaine | $43.36 | $43.36 |
| Southern Maine, MEMaine | $44.35 | $44.35 |
| Detroit, MIMichigan | $45.76 | $45.76 |
| Rest of MichiganMichigan | $44.12 | $44.12 |
| MinnesotaMinnesota | $44.31 | $44.31 |
| Metropolitan Kansas City, MOMissouri | $44.22 | $44.22 |
| Metropolitan St. Louis, MOMissouri | $44.44 | $44.44 |
| Rest of MissouriMissouri | $43.16 | $43.16 |
| MontanaMontana | $45.09 | $45.09 |
| North CarolinaNorth Carolina | $43.57 | $43.57 |
| North DakotaNorth Dakota | $44.10 | $44.10 |
| NebraskaNebraska | $43.00 | $43.00 |
| New HampshireNew Hampshire | $45.44 | $45.44 |
| Northern New JerseyNew Jersey | $49.27 | $49.27 |
| Rest of New JerseyNew Jersey | $47.70 | $47.70 |
| New MexicoNew Mexico | $44.29 | $44.29 |
| NevadaNevada | $44.83 | $44.83 |
| NYC suburbs and Long Island, NYNew York | $51.01 | $51.01 |
| Poughkeepsie and northern NYC suburbs, NYNew York | $48.08 | $48.08 |
| Queens, NYNew York | $50.22 | $50.22 |
| Rest of New YorkNew York | $43.91 | $43.91 |
| OhioOhio | $43.91 | $43.91 |
| OklahomaOklahoma | $43.25 | $43.25 |
| Portland, OROregon | $46.66 | $46.66 |
| Rest of OregonOregon | $44.54 | $44.54 |
| Metropolitan Philadelphia, PAPennsylvania | $46.51 | $46.51 |
| Rest of PennsylvaniaPennsylvania | $43.88 | $43.88 |
| Puerto RicoPuerto Rico | $45.22 | $45.22 |
| Rhode IslandRhode Island | $45.93 | $45.93 |
| South CarolinaSouth Carolina | $43.80 | $43.80 |
| South DakotaSouth Dakota | $43.98 | $43.98 |
| TennesseeTennessee | $43.07 | $43.07 |
| Austin, TXTexas | $45.75 | $45.75 |
| Beaumont, TXTexas | $43.74 | $43.74 |
| Brazoria, TXTexas | $44.84 | $44.84 |
| Dallas, TXTexas | $45.07 | $45.07 |
| Fort Worth, TXTexas | $44.95 | $44.95 |
| Galveston, TXTexas | $44.95 | $44.95 |
| Houston, TXTexas | $45.86 | $45.86 |
| Rest of TexasTexas | $44.23 | $44.23 |
| UtahUtah | $44.10 | $44.10 |
| VirginiaVirginia | $44.37 | $44.37 |
| Virgin Islands, VIUnited States Virgin Islands | $45.22 | $45.22 |
| VermontVermont | $44.13 | $44.13 |
| Rest of WashingtonWashington | $45.80 | $45.80 |
| King County, WAWashington | $49.38 | $49.38 |
| WisconsinWisconsin | $43.36 | $43.36 |
| West VirginiaWest Virginia | $44.02 | $44.02 |
| WyomingWyoming | $44.66 | $44.66 |
88375 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$42.35
$60.09
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $60.09 | 1 |
| AL | $42.65 | 1 |
| AR | $42.35 | 1 |
| AZ | $44.43 | 1 |
| CA | $46.14–$53.64 | 29 |
| CO | $45.96 | 1 |
| CT | $47.09 | 1 |
| DC | $49.32 | 1 |
| DE | $44.91 | 1 |
| FL | $45.33–$48.21 | 3 |
| GA | $43.93–$45.74 | 2 |
| GU | $46.26 | 1 |
| HI | $46.26 | 1 |
| IA | $42.92 | 1 |
| ID | $43.12 | 1 |
| IL | $44.84–$47.53 | 4 |
| IN | $43.23 | 1 |
| KS | $42.95 | 1 |
| KY | $43.43 | 1 |
| LA | $43.45–$44.51 | 2 |
| MA | $45.95–$48.78 | 2 |
| MD | $45.42–$49.32 | 3 |
| ME | $43.36–$44.35 | 2 |
| MI | $44.12–$45.76 | 2 |
| MN | $44.31 | 1 |
| MO | $43.16–$44.44 | 3 |
| MS | $42.75 | 1 |
| MT | $45.09 | 1 |
| NC | $43.57 | 1 |
| ND | $44.10 | 1 |
| NE | $43.00 | 1 |
| NH | $45.44 | 1 |
| NJ | $47.70–$49.27 | 2 |
| NM | $44.29 | 1 |
| NV | $44.83 | 1 |
| NY | $43.91–$51.01 | 5 |
| OH | $43.91 | 1 |
| OK | $43.25 | 1 |
| OR | $44.54–$46.66 | 2 |
| PA | $43.88–$46.51 | 2 |
| PR | $45.22 | 1 |
| RI | $45.93 | 1 |
| SC | $43.80 | 1 |
| SD | $43.98 | 1 |
| TN | $43.07 | 1 |
| TX | $43.74–$45.86 | 8 |
| UT | $44.10 | 1 |
| VA | $44.37–$49.32 | 2 |
| VI | $45.22 | 1 |
| VT | $44.13 | 1 |
| WA | $45.80–$49.38 | 2 |
| WI | $43.36 | 1 |
| WV | $44.02 | 1 |
| WY | $44.66 | 1 |
How the 88375 rate is calculated
Each of 88375’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88375
RVUs × geographic indexes × conversion factor
Work0.89
0.89 RVUs× 1.000 GPCI
Practice expense0.41
0.41 RVUs× 1.000 GPCI
Malpractice0.05
0.05 RVUs× 1.000 GPCI
Adjusted RVUs
1.3500
Conversion factor
$33.4009
Medicare rate
$45.09
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Mississippi inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,313
- Code
- 88375
- Physician work
- 0.89
- Practice expense
- 0.41
- Malpractice
- 0.05
GPCI2026.csv
67
- Locality
- Mississippi
- Physician work
- 1.000
- Practice expense
- 0.861
- Malpractice
- 0.739
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.89 | × 1.000 | 0.8900 |
| Practice expense | 0.41 | × 0.861 | 0.3530 |
| Malpractice | 0.05 | × 0.739 | 0.0370 |
| Total RVUs | 1.2800 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Mississippi$42.75
Office: (0.89 × 1 + 0.41 × 0.861 + 0.05 × 0.739) × $33.4009 = $42.75
Facility: (0.89 × 1 + 0.41 × 0.861 + 0.05 × 0.739) × $33.4009 = $42.75
Payment rules and modifiers for 88375
The CMS indicators that decide how 88375 is paid alongside other services.
CMS payment indicators · 88375
Optical endomicroscopy, professional component
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 2 | Professional component only. |
How 88375 has changed in Mississippi
88375 · Office / nonfacility
$42.75
Effective 2026-10-01
The base rate is $0.19 higher than on 2025-10-01, moving from $42.56 to $42.75 (0.4%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$42.56changed to$42.75
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.91 changed to 0.89
- Practice expense RVU 0.44 changed to 0.41
- Malpractice RVU 0.04 changed to 0.05
- Practice expense GPCI 0.852 changed to 0.861
- Malpractice GPCI 0.768 changed to 0.739
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$44.05changed to$42.56
- Conversion factor 33.2875 changed to 32.3465
- Malpractice RVU 0.05 changed to 0.04
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$43.33changed to$44.05
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$44.73changed to$43.33
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 0.45 changed to 0.44
- Malpractice RVU 0.04 changed to 0.05
- Practice expense GPCI 0.847 changed to 0.852
- Malpractice GPCI 0.720 changed to 0.768
January 1, 2023
RVU23A
$45.47changed to$44.73
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 0.44 changed to 0.45
- Malpractice RVU 0.05 changed to 0.04
- Practice expense GPCI 0.842 changed to 0.847
- Malpractice GPCI 0.671 changed to 0.720
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$46.14changed to$45.47
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 0.45 changed to 0.44
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$47.99changed to$46.14
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 0.46 changed to 0.45
- Practice expense GPCI 0.856 changed to 0.842
- Malpractice GPCI 0.521 changed to 0.671
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$47.89changed to$47.99
- Conversion factor 36.0391 changed to 36.0896
- Practice expense GPCI 0.870 changed to 0.856
- Malpractice GPCI 0.370 changed to 0.521
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$48.77changed to$47.89
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 0.49 changed to 0.46
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$44.43changed to$48.77
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 0.35 changed to 0.49
- Practice expense GPCI 0.867 changed to 0.870
- Malpractice GPCI 0.492 changed to 0.370
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$47.29changed to$44.43
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 0.44 changed to 0.35
- Practice expense GPCI 0.864 changed to 0.867
- Malpractice GPCI 0.613 changed to 0.492
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$45.60changed to$47.29
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 0.38 changed to 0.44
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$45.37changed to$45.60
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
No ratechanged to$45.37
Held through RVU15B.
January 1, 2014
RVU14A
No ratechanged toNo rate
Held through RVU14B, RVU14C, RVU14D.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $42.75 | $42.75 | RVU26D |
| 2026-07-01 | $42.75 | $42.75 | RVU26C |
| 2026-04-01 | $42.75 | $42.75 | RVU26B |
| 2026-01-01 | $42.75 | $42.75 | RVU26A |
| 2025-10-01 | $42.56 | $42.56 | RVU25D |
| 2025-07-01 | $42.56 | $42.56 | RVU25C |
| 2025-04-01 | $42.56 | $42.56 | RVU25B |
| 2025-01-01 | $42.56 | $42.56 | RVU25A |
| 2024-10-01 | $44.05 | $44.05 | RVU24D |
| 2024-07-01 | $44.05 | $44.05 | RVU24C |
| 2024-04-01 | $44.05 | $44.05 | RVU24B |
| 2024-03-09 | $44.05 | $44.05 | RVU24AR |
| 2024-01-01 | $43.33 | $43.33 | RVU24A |
| 2023-10-01 | $44.73 | $44.73 | RVU23D |
| 2023-07-01 | $44.73 | $44.73 | RVU23C |
| 2023-04-01 | $44.73 | $44.73 | RVU23B |
| 2023-01-01 | $44.73 | $44.73 | RVU23A |
| 2022-10-01 | $45.47 | $45.47 | RVU22D |
| 2022-07-01 | $45.47 | $45.47 | RVU22C |
| 2022-04-01 | $45.47 | $45.47 | RVU22B |
| 2022-01-01 | $45.47 | $45.47 | RVU22A |
| 2021-10-01 | $46.14 | $46.14 | RVU21D |
| 2021-07-01 | $46.14 | $46.14 | RVU21C |
| 2021-04-01 | $46.14 | $46.14 | RVU21B |
| 2021-01-01 | $46.14 | $46.14 | RVU21A |
| 2020-10-01 | $47.99 | $47.99 | RVU20D |
| 2020-07-01 | $47.99 | $47.99 | RVU20C |
| 2020-04-01 | $47.99 | $47.99 | RVU20B |
| 2020-01-01 | $47.99 | $47.99 | RVU20A |
| 2019-10-01 | $47.89 | $47.89 | RVU19D |
| 2019-07-01 | $47.89 | $47.89 | RVU19C |
| 2019-04-01 | $47.89 | $47.89 | RVU19B |
| 2019-01-01 | $47.89 | $47.89 | RVU19A |
| 2018-10-01 | $48.77 | $48.77 | RVU18D |
| 2018-07-01 | $48.77 | $48.77 | RVU18C |
| 2018-04-01 | $48.77 | $48.77 | RVU18B |
| 2018-01-01 | $48.77 | $48.77 | RVU18AR1 |
| 2017-10-01 | $44.43 | $44.43 | RVU17D |
| 2017-07-01 | $44.43 | $44.43 | RVU17C |
| 2017-04-01 | $44.43 | $44.43 | RVU17B |
| 2017-01-01 | $44.43 | $44.43 | RVU17A |
| 2016-10-01 | $47.29 | $47.29 | RVU16D |
| 2016-07-01 | $47.29 | $47.29 | RVU16C |
| 2016-04-01 | $47.29 | $47.29 | RVU16B |
| 2016-01-01 | $47.29 | $47.29 | RVU16A |
| 2015-10-01 | $45.60 | $45.60 | RVU15D |
| 2015-07-01 | $45.60 | $45.60 | RVU15C |
| 2015-04-01 | $45.37 | $45.37 | RVU15B |
| 2015-01-01 | $45.37 | $45.37 | RVU15A |
| 2014-10-01 | Separate payment rules apply | Separate payment rules apply | RVU14D |
| 2014-07-01 | Separate payment rules apply | Separate payment rules apply | RVU14C |
| 2014-04-01 | Separate payment rules apply | Separate payment rules apply | RVU14B |
| 2014-01-01 | Separate payment rules apply | Separate payment rules apply | RVU14A |
| 2013-10-01 | Contractor-priced | Contractor-priced | RVU13D |
| 2013-07-01 | Contractor-priced | Contractor-priced | RVU13C |
| 2013-04-01 | Contractor-priced | Contractor-priced | RVU13B |
| 2013-01-01 | Contractor-priced | Contractor-priced | RVU13AR |
Where the Mississippi rate applies
Mississippi is a Medicare payment area, not a city. Our Census mapping connects it to 427 cities and communities in Mississippi. Some span more than one payment area; confirm with the service ZIP.
- Abbeville
- Aberdeen
- Ackerman
- Agricola
- Alcorn State University
- Algoma
- Alligator
- Amory
88375 billing questions
Does 88375 include the equipment and image acquisition?
No. It represents the physician’s interpretation and report; a separate code covers the technical portion.
How does 88375 differ from 88376?
88375 reports interpretation and reporting of the images. 88376 covers the technical portion of optical endomicroscopy.
Is 88375 the same as a biopsy pathology examination?
No. It reports interpretation of optical endomicroscopy images, rather than microscopic examination of a removed tissue specimen.
What documentation supports reporting 88375?
Document the optical endomicroscopy images reviewed, the physician’s findings, and a report of the interpretation.
Can 88375 be reported with an endoscopy that uses optical endomicroscopy?
It may represent the interpretation service associated with an endoscopic study; the endoscopy code describes the procedure, while 88375 represents the image interpretation and report.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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