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CPT code 88375: Optical endomicroscopy, professional component2026 Medicare rate & RVUs in Puerto Rico

Report this service for a physician’s interpretation and report of real-time or recorded optical endomicroscopy images obtained during microscopic tissue assessment.

CMS RVU26DEffective Oct 1, 2026One payment locality269 Medicare services in 2024

In Puerto Rico, Medicare pays $45.22 for 88375 in the office and $45.22 when it’s performed in a hospital or facility.

$45.22Office (non-facility)
$45.22Hospital or facility
+0.3%vs the national office rate ($45.09)

Check a contract rate as a % of Medicare · 88375 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 88375 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Puerto Rico
  2. What 88375 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 88375 covers

Optical endomicroscopy produces microscopic images of tissue in a clinical setting, commonly during gastrointestinal endoscopy. The physician reviews real-time or recorded images to assess cellular and tissue features and prepares an interpretation and report. This is image-based assessment, distinct from examining a removed specimen on a conventional pathology slide.

Report 88375 for the professional interpretation and report, not for acquiring the images or furnishing the equipment and other technical work. CMS identifies this as a professional-component-only code; a separate code covers the technical portion. Documentation should identify the optical endomicroscopy study, the images reviewed, the physician’s findings, and the resulting interpretation. When optical endomicroscopy is performed as part of an endoscopic procedure, the endoscopy code describes that procedure; 88375 represents the separately coded interpretation service.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Puerto Rico compares for 88375

Across 109 of 109 payment localities, the office rate for 88375 runs from $42.35 in Arkansas to $60.09 in Alaska. Puerto Rico pays $45.22. The RVUs are the same everywhere; the geographic indexes change the dollars.

88375 in Puerto Rico vs other payment areas
  1. Puerto Rico · this page$45.22
  2. Los Angeles, CA · California$48.25+$3.03
  3. Washington, DC area · District of Columbia$49.32+$4.10
  4. Miami, FL · Florida$48.21+$2.99
  5. Chicago, IL · Illinois$47.53+$2.31
  6. Manhattan, NY · New York$50.19+$4.97
  7. Alaska · Alaska$60.09+$14.87

Other areas in Puerto Rico first, then benchmark localities. Bars start at $0.

Every other payment area

88375 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$42.65$42.65
ArkansasArkansas$42.35$42.35
ArizonaArizona$44.43$44.43
Bakersfield, CACalifornia$46.32$46.32
Chico, CACalifornia$46.14$46.14
El Centro, CACalifornia$46.14$46.14
Fresno, CACalifornia$46.14$46.14
Hanford, CACalifornia$46.14$46.14

88375 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$42.35

$60.09

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
88375 office rate range by state
State / territoryOffice rate rangeLocalities
AK$60.091
AL$42.651
AR$42.351
AZ$44.431
CA$46.14–$53.6429
CO$45.961
CT$47.091
DC$49.321
DE$44.911
FL$45.33–$48.213
GA$43.93–$45.742
GU$46.261
HI$46.261
IA$42.921
ID$43.121
IL$44.84–$47.534
IN$43.231
KS$42.951
KY$43.431
LA$43.45–$44.512
MA$45.95–$48.782
MD$45.42–$49.323
ME$43.36–$44.352
MI$44.12–$45.762
MN$44.311
MO$43.16–$44.443
MS$42.751
MT$45.091
NC$43.571
ND$44.101
NE$43.001
NH$45.441
NJ$47.70–$49.272
NM$44.291
NV$44.831
NY$43.91–$51.015
OH$43.911
OK$43.251
OR$44.54–$46.662
PA$43.88–$46.512
PR$45.221
RI$45.931
SC$43.801
SD$43.981
TN$43.071
TX$43.74–$45.868
UT$44.101
VA$44.37–$49.322
VI$45.221
VT$44.131
WA$45.80–$49.382
WI$43.361
WV$44.021
WY$44.661

See 88375 in every payment locality

How the 88375 rate is calculated

Each of 88375’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 88375

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.89

0.89 RVUs× 1.000 GPCI

Practice expense0.41

0.41 RVUs× 1.000 GPCI

Malpractice0.05

0.05 RVUs× 1.000 GPCI

Adjusted RVUs

1.3500

Conversion factor

$33.4009

Medicare rate

$45.09

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Puerto Rico inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

11,313

Code
88375
Physician work
0.89
Practice expense
0.41
Malpractice
0.05

GPCI2026.csv

91

Locality
Puerto Rico
Physician work
1.000
Practice expense
1.011
Malpractice
0.985
Office calculation for 88375 in Puerto Rico
ComponentRVULocality factorAdjusted
Physician work0.89× 1.0000.8900
Practice expense0.41× 1.0110.4145
Malpractice0.05× 0.9850.0493
Total RVUs1.3538
Conversion factor× 33.4009

Office rate, Puerto Rico$45.22

Office: (0.89 × 1 + 0.41 × 1.011 + 0.05 × 0.985) × $33.4009 = $45.22

Facility: (0.89 × 1 + 0.41 × 1.011 + 0.05 × 0.985) × $33.4009 = $45.22

Open 88375 in the RVU calculator

Payment rules and modifiers for 88375

The CMS indicators that decide how 88375 is paid alongside other services.

CMS payment indicators · 88375

Optical endomicroscopy, professional component

RuleCMS valueWhat it means
Global periodXXXThe global surgery concept doesn’t apply.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical2Professional component only.

Codes related to 88375

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to 88375
CodeHow it relatesOffice range, Puerto Rico
Often billed with
43206Esophagoscopy, optical endomicroscopyEsophagoscopy code associated with optical endomicroscopy; 88375 represents image interpretation.$343.07
43252Optical endomicroscopy, during upper endoscopyUpper endoscopy code associated with optical endomicroscopy; 88375 represents image interpretation.$379.88
45342Sigmoidoscopy, ultrasound-guided tissue samplingColonoscopy code associated with optical endomicroscopy; 88375 represents image interpretation.No office rate

How 88375 has changed in Puerto Rico

88375 · Office / nonfacility

$45.22

Effective 2026-10-01

The base rate is $0.18 higher than on 2025-10-01, moving from $45.04 to $45.22 (0.4%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $45.04changed to$45.22

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.91 changed to 0.89
    • Practice expense RVU 0.44 changed to 0.41
    • Malpractice RVU 0.04 changed to 0.05
    • Practice expense GPCI 1.007 changed to 1.011
    • Malpractice GPCI 0.982 changed to 0.985

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $46.68changed to$45.04

    • Conversion factor 33.2875 changed to 32.3465
    • Malpractice RVU 0.05 changed to 0.04

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $45.91changed to$46.68

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $47.54changed to$45.91

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 0.45 changed to 0.44
    • Malpractice RVU 0.04 changed to 0.05
    • Practice expense GPCI 1.008 changed to 1.007
    • Malpractice GPCI 0.984 changed to 0.982

  5. October 1, 2023

    RVU23D

    $47.44changed to$47.54

    • Practice expense GPCI 1.000 changed to 1.008
    • Malpractice GPCI 1.000 changed to 0.984

  6. January 1, 2023

    RVU23A

    $48.55changed to$47.44

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 0.44 changed to 0.45
    • Malpractice RVU 0.05 changed to 0.04
    • Practice expense GPCI 1.008 changed to 1.000
    • Malpractice GPCI 0.986 changed to 1.000

    Held through RVU23B, RVU23C.

  7. January 1, 2022

    RVU22A

    $49.30changed to$48.55

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 0.45 changed to 0.44

    Held through RVU22B, RVU22C, RVU22D.

  8. January 1, 2021

    RVU21A

    $51.36changed to$49.30

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 0.46 changed to 0.45
    • Malpractice GPCI 0.988 changed to 0.986

    Held through RVU21B, RVU21C, RVU21D.

  9. January 1, 2020

    RVU20A

    $51.27changed to$51.36

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense GPCI 1.007 changed to 1.008
    • Malpractice GPCI 0.990 changed to 0.988

    Held through RVU20B, RVU20C, RVU20D.

  10. January 1, 2019

    RVU19A

    $52.30changed to$51.27

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 0.49 changed to 0.46

    Held through RVU19B, RVU19C, RVU19D.

  11. January 1, 2018

    RVU18AR1

    $44.56changed to$52.30

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 0.35 changed to 0.49
    • Practice expense GPCI 0.856 changed to 1.007
    • Malpractice GPCI 0.642 changed to 0.990

    Held through RVU18B, RVU18C, RVU18D.

  12. January 1, 2017

    RVU17A

    $44.21changed to$44.56

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 0.44 changed to 0.35
    • Practice expense GPCI 0.705 changed to 0.856
    • Malpractice GPCI 0.293 changed to 0.642

    Held through RVU17B, RVU17C, RVU17D.

  13. January 1, 2016

    RVU16A

    $42.85changed to$44.21

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 0.38 changed to 0.44

    Held through RVU16B, RVU16C, RVU16D.

  14. July 1, 2015

    RVU15C

    $42.64changed to$42.85

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  15. January 1, 2015

    RVU15A

    No ratechanged to$42.64

    Held through RVU15B.

  16. January 1, 2014

    RVU14A

    No ratechanged toNo rate

    Held through RVU14B, RVU14C, RVU14D.

  17. January 1, 2013

    RVU13AR

    Earliest loaded release: No rate

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$45.22$45.22RVU26D
2026-07-01$45.22$45.22RVU26C
2026-04-01$45.22$45.22RVU26B
2026-01-01$45.22$45.22RVU26A
2025-10-01$45.04$45.04RVU25D
2025-07-01$45.04$45.04RVU25C
2025-04-01$45.04$45.04RVU25B
2025-01-01$45.04$45.04RVU25A
2024-10-01$46.68$46.68RVU24D
2024-07-01$46.68$46.68RVU24C
2024-04-01$46.68$46.68RVU24B
2024-03-09$46.68$46.68RVU24AR
2024-01-01$45.91$45.91RVU24A
2023-10-01$47.54$47.54RVU23D
2023-07-01$47.44$47.44RVU23C
2023-04-01$47.44$47.44RVU23B
2023-01-01$47.44$47.44RVU23A
2022-10-01$48.55$48.55RVU22D
2022-07-01$48.55$48.55RVU22C
2022-04-01$48.55$48.55RVU22B
2022-01-01$48.55$48.55RVU22A
2021-10-01$49.30$49.30RVU21D
2021-07-01$49.30$49.30RVU21C
2021-04-01$49.30$49.30RVU21B
2021-01-01$49.30$49.30RVU21A
2020-10-01$51.36$51.36RVU20D
2020-07-01$51.36$51.36RVU20C
2020-04-01$51.36$51.36RVU20B
2020-01-01$51.36$51.36RVU20A
2019-10-01$51.27$51.27RVU19D
2019-07-01$51.27$51.27RVU19C
2019-04-01$51.27$51.27RVU19B
2019-01-01$51.27$51.27RVU19A
2018-10-01$52.30$52.30RVU18D
2018-07-01$52.30$52.30RVU18C
2018-04-01$52.30$52.30RVU18B
2018-01-01$52.30$52.30RVU18AR1
2017-10-01$44.56$44.56RVU17D
2017-07-01$44.56$44.56RVU17C
2017-04-01$44.56$44.56RVU17B
2017-01-01$44.56$44.56RVU17A
2016-10-01$44.21$44.21RVU16D
2016-07-01$44.21$44.21RVU16C
2016-04-01$44.21$44.21RVU16B
2016-01-01$44.21$44.21RVU16A
2015-10-01$42.85$42.85RVU15D
2015-07-01$42.85$42.85RVU15C
2015-04-01$42.64$42.64RVU15B
2015-01-01$42.64$42.64RVU15A
2014-10-01Separate payment rules applySeparate payment rules applyRVU14D
2014-07-01Separate payment rules applySeparate payment rules applyRVU14C
2014-04-01Separate payment rules applySeparate payment rules applyRVU14B
2014-01-01Separate payment rules applySeparate payment rules applyRVU14A
2013-10-01Contractor-pricedContractor-pricedRVU13D
2013-07-01Contractor-pricedContractor-pricedRVU13C
2013-04-01Contractor-pricedContractor-pricedRVU13B
2013-01-01Contractor-pricedContractor-pricedRVU13AR

Price 88375 for an earlier date of service

Where the Puerto Rico rate applies

Puerto Rico is a Medicare payment area, not a city. Our Census mapping connects it to 292 cities and communities in Puerto Rico. Some span more than one payment area; confirm with the service ZIP.

  • Aceitunas
  • Adjuntas
  • Aguada
  • Aguadilla
  • Aguas Buenas
  • Aguas Claras
  • Aguilita
  • Aibonito

Browse all communities in Puerto Rico

88375 billing questions

Does 88375 include the equipment and image acquisition?

No. It represents the physician’s interpretation and report; a separate code covers the technical portion.

How does 88375 differ from 88376?

88375 reports interpretation and reporting of the images. 88376 covers the technical portion of optical endomicroscopy.

Is 88375 the same as a biopsy pathology examination?

No. It reports interpretation of optical endomicroscopy images, rather than microscopic examination of a removed tissue specimen.

What documentation supports reporting 88375?

Document the optical endomicroscopy images reviewed, the physician’s findings, and a report of the interpretation.

Can 88375 be reported with an endoscopy that uses optical endomicroscopy?

It may represent the interpretation service associated with an endoscopic study; the endoscopy code describes the procedure, while 88375 represents the image interpretation and report.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 88375PPRRVU2026_Oct_nonQPP.csv, line 11,313 (RVU26D)
Geographic factors for Puerto RicoGPCI2026.csv, line 91 (RVU26D)

Open CMS sourceHow we calculate rates

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