HCPCS code G0452: Molecular interpretation, physician interpretation and report2026 Medicare rate & RVUs in Iowa
Reports a physician’s interpretation of molecular pathology test results, separately from or as part of the global diagnostic service.
In Iowa, Medicare pays $45.02 for G0452 in the office.
Check a contract rate as a % of Medicare · G0452 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What G0452 covers
A physician reviews results from a molecular pathology assay and prepares an interpretation and report. The testing may analyze DNA or RNA from sources such as tumor tissue or blood to identify molecular findings relevant to diagnosis or treatment. A pathologist or another qualified physician may provide this service in a hospital, reference laboratory, or other setting where molecular diagnostic testing is performed.
Report G0452 for the physician’s interpretive service when supported by the work documented; the assay itself is represented by its applicable test code. CMS recognizes professional and technical components: modifier 26 identifies the interpretation, and modifier TC identifies the technical work, including equipment and staff. Without either modifier, the claim represents the global service. Documentation should identify the test results reviewed and include the physician’s interpretive findings and report. CMS lists modifiers 26 and TC as separately priced.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Iowa compares for G0452
Across 109 of 109 payment localities, the office rate for G0452 runs from $44.22 in Arkansas to $62.68 in Alaska. Iowa pays $45.02. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Iowa · this page$45.02
- Los Angeles, CA · California$50.66+$5.64
- Washington, DC area · District of Columbia$51.27+$6.25
- Miami, FL · Florida$48.43+$3.41
- Chicago, IL · Illinois$47.92+$2.90
- Manhattan, NY · New York$51.64+$6.62
- Alaska · Alaska$62.68+$17.66
Other areas in Iowa first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $44.51 | — |
| ArkansasArkansas | $44.22 | — |
| ArizonaArizona | $46.18 | — |
| Bakersfield, CACalifornia | $48.58 | — |
| Chico, CACalifornia | $48.48 | — |
| El Centro, CACalifornia | $48.48 | — |
| Fresno, CACalifornia | $48.48 | — |
| Hanford, CACalifornia | $48.48 | — |
| Madera, CACalifornia | $48.48 | — |
| Merced, CACalifornia | $48.48 | — |
| Modesto, CACalifornia | $48.48 | — |
| Napa, CACalifornia | $53.34 | — |
| Oxnard, CACalifornia | $50.22 | — |
| Redding, CACalifornia | $48.48 | — |
| Rest of CaliforniaCalifornia | $48.48 | — |
| Riverside, CACalifornia | $48.72 | — |
| Sacramento, CACalifornia | $50.10 | — |
| Salinas, CACalifornia | $49.89 | — |
| San Diego, CACalifornia | $50.44 | — |
| Marin County, CACalifornia | $55.72 | — |
| San Francisco, CACalifornia | $55.70 | — |
| San Benito County, CACalifornia | $56.73 | — |
| Santa Clara County, CACalifornia | $56.64 | — |
| San Luis Obispo, CACalifornia | $49.15 | — |
| Santa Cruz, CACalifornia | $50.46 | — |
| Santa Maria, CACalifornia | $49.91 | — |
| Santa Rosa, CACalifornia | $50.94 | — |
| Stockton, CACalifornia | $48.48 | — |
| Vallejo, CACalifornia | $53.31 | — |
| Visalia, CACalifornia | $48.48 | — |
| Yuba City, CACalifornia | $48.48 | — |
| ColoradoColorado | $47.98 | — |
| ConnecticutConnecticut | $48.72 | — |
| DelawareDelaware | $46.66 | — |
| Fort Lauderdale, FLFlorida | $47.51 | — |
| Rest of FloridaFlorida | $46.41 | — |
| Atlanta, GAGeorgia | $47.24 | — |
| Rest of GeorgiaGeorgia | $45.19 | — |
| Hawaii, Guam, HIHawaii | $48.63 | — |
| IdahoIdaho | $45.15 | — |
| East St. Louis, ILIllinois | $46.18 | — |
| Rest of IllinoisIllinois | $45.77 | — |
| Suburban Chicago, ILIllinois | $47.91 | — |
| IndianaIndiana | $45.27 | — |
| KansasKansas | $44.92 | — |
| KentuckyKentucky | $44.96 | — |
| New Orleans, LALouisiana | $45.93 | — |
| Rest of LouisianaLouisiana | $44.93 | — |
| Metropolitan Boston, MAMassachusetts | $50.98 | — |
| Rest of MassachusettsMassachusetts | $47.94 | — |
| Baltimore area, MDMaryland | $48.55 | — |
| Rest of MarylandMaryland | $47.20 | — |
| Rest of MaineMaine | $45.25 | — |
| Southern Maine, MEMaine | $46.37 | — |
| Detroit, MIMichigan | $46.67 | — |
| Rest of MichiganMichigan | $45.48 | — |
| MinnesotaMinnesota | $46.75 | — |
| Metropolitan Kansas City, MOMissouri | $45.79 | — |
| Metropolitan St. Louis, MOMissouri | $46.01 | — |
| Rest of MissouriMissouri | $44.58 | — |
| MississippiMississippi | $44.40 | — |
| MontanaMontana | $46.76 | — |
| North CarolinaNorth Carolina | $45.47 | — |
| North DakotaNorth Dakota | $46.36 | — |
| NebraskaNebraska | $45.14 | — |
| New HampshireNew Hampshire | $47.32 | — |
| Northern New JerseyNew Jersey | $51.23 | — |
| Rest of New JerseyNew Jersey | $49.49 | — |
| New MexicoNew Mexico | $45.59 | — |
| NevadaNevada | $46.67 | — |
| NYC suburbs and Long Island, NYNew York | $52.25 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $49.76 | — |
| Queens, NYNew York | $51.86 | — |
| Rest of New YorkNew York | $45.78 | — |
| OhioOhio | $45.40 | — |
| OklahomaOklahoma | $44.93 | — |
| Portland, OROregon | $48.82 | — |
| Rest of OregonOregon | $46.50 | — |
| Metropolitan Philadelphia, PAPennsylvania | $48.08 | — |
| Rest of PennsylvaniaPennsylvania | $45.44 | — |
| Puerto RicoPuerto Rico | $46.92 | — |
| Rhode IslandRhode Island | $47.78 | — |
| South CarolinaSouth Carolina | $45.47 | — |
| South DakotaSouth Dakota | $46.32 | — |
| TennesseeTennessee | $45.02 | — |
| Austin, TXTexas | $47.66 | — |
| Beaumont, TXTexas | $45.30 | — |
| Brazoria, TXTexas | $46.72 | — |
| Dallas, TXTexas | $46.88 | — |
| Fort Worth, TXTexas | $46.73 | — |
| Galveston, TXTexas | $46.78 | — |
| Houston, TXTexas | $47.15 | — |
| Rest of TexasTexas | $45.90 | — |
| UtahUtah | $45.75 | — |
| VirginiaVirginia | $46.30 | — |
| Virgin Islands, VIUnited States Virgin Islands | $46.92 | — |
| VermontVermont | $46.27 | — |
| Rest of WashingtonWashington | $47.83 | — |
| King County, WAWashington | $51.72 | — |
| WisconsinWisconsin | $45.64 | — |
| West VirginiaWest Virginia | $44.99 | — |
| WyomingWyoming | $46.59 | — |
G0452 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$44.22
$62.68
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $62.68 | 1 |
| AL | $44.51 | 1 |
| AR | $44.22 | 1 |
| AZ | $46.18 | 1 |
| CA | $48.48–$56.73 | 29 |
| CO | $47.98 | 1 |
| CT | $48.72 | 1 |
| DC | $51.27 | 1 |
| DE | $46.66 | 1 |
| FL | $46.41–$48.43 | 3 |
| GA | $45.19–$47.24 | 2 |
| GU | $48.63 | 1 |
| HI | $48.63 | 1 |
| IA | $45.02 | 1 |
| ID | $45.15 | 1 |
| IL | $45.77–$47.92 | 4 |
| IN | $45.27 | 1 |
| KS | $44.92 | 1 |
| KY | $44.96 | 1 |
| LA | $44.93–$45.93 | 2 |
| MA | $47.94–$50.98 | 2 |
| MD | $47.20–$51.27 | 3 |
| ME | $45.25–$46.37 | 2 |
| MI | $45.48–$46.67 | 2 |
| MN | $46.75 | 1 |
| MO | $44.58–$46.01 | 3 |
| MS | $44.40 | 1 |
| MT | $46.76 | 1 |
| NC | $45.47 | 1 |
| ND | $46.36 | 1 |
| NE | $45.14 | 1 |
| NH | $47.32 | 1 |
| NJ | $49.49–$51.23 | 2 |
| NM | $45.59 | 1 |
| NV | $46.67 | 1 |
| NY | $45.78–$52.25 | 5 |
| OH | $45.40 | 1 |
| OK | $44.93 | 1 |
| OR | $46.50–$48.82 | 2 |
| PA | $45.44–$48.08 | 2 |
| PR | $46.92 | 1 |
| RI | $47.78 | 1 |
| SC | $45.47 | 1 |
| SD | $46.32 | 1 |
| TN | $45.02 | 1 |
| TX | $45.30–$47.66 | 8 |
| UT | $45.75 | 1 |
| VA | $46.30–$51.27 | 2 |
| VI | $46.92 | 1 |
| VT | $46.27 | 1 |
| WA | $47.83–$51.72 | 2 |
| WI | $45.64 | 1 |
| WV | $44.99 | 1 |
| WY | $46.59 | 1 |
How the G0452 rate is calculated
Each of G0452’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · G0452
RVUs × geographic indexes × conversion factor
Work0.91
0.91 RVUs× 1.000 GPCI
Practice expense0.47
0.47 RVUs× 1.000 GPCI
Malpractice0.02
0.02 RVUs× 1.000 GPCI
Adjusted RVUs
1.4000
Conversion factor
$33.4009
Medicare rate
$46.76
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Iowa inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
15,270
- Code
- G0452
- Physician work
- 0.91
- Practice expense
- 0.47
- Malpractice
- 0.02
GPCI2026.csv
53
- Locality
- Iowa
- Physician work
- 1.000
- Practice expense
- 0.915
- Malpractice
- 0.397
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.91 | × 1.000 | 0.9100 |
| Practice expense | 0.47 | × 0.915 | 0.4300 |
| Malpractice | 0.02 | × 0.397 | 0.0079 |
| Total RVUs | 1.3480 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Iowa$45.02
Office: (0.91 × 1 + 0.47 × 0.915 + 0.02 × 0.397) × $33.4009 = $45.02
Payment rules and modifiers for G0452
The CMS indicators that decide how G0452 is paid alongside other services.
CMS payment indicators · G0452
Molecular interpretation, physician interpretation and report
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
G0452 without 26 · national office
$46.76
Molecular interpretation, physician interpretation and report
G0452-26 · Professional component
$43.76
Pays only the interpretation and report.
How G0452 has changed in Iowa
G0452 · Office / nonfacility
$45.02
Effective 2026-10-01
The base rate is $0.42 lower than on 2025-10-01, moving from $45.44 to $45.02 (0.9%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$45.44changed to$45.02
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.93 changed to 0.91
- Practice expense RVU 0.51 changed to 0.47
- Practice expense GPCI 0.913 changed to 0.915
- Malpractice GPCI 0.457 changed to 0.397
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$46.91changed to$45.44
- Conversion factor 33.2875 changed to 32.3465
- Malpractice RVU 0.03 changed to 0.02
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$46.15changed to$46.91
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$47.69changed to$46.15
- Conversion factor 33.8872 changed to 32.7442
- Practice expense GPCI 0.910 changed to 0.913
- Malpractice GPCI 0.441 changed to 0.457
January 1, 2023
RVU23A
$46.73changed to$47.69
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 0.44 changed to 0.51
- Malpractice RVU 0.05 changed to 0.03
- Practice expense GPCI 0.907 changed to 0.910
- Malpractice GPCI 0.425 changed to 0.441
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$47.12changed to$46.73
- Conversion factor 34.8931 changed to 34.6062
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
No ratechanged to$47.12
Held through RVU21B, RVU21C, RVU21D.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D, RVU15A, RVU15B, RVU15C, RVU15D, RVU16A, RVU16B, RVU16C, RVU16D, RVU17A, RVU17B, RVU17C, RVU17D, RVU18AR1, RVU18B, RVU18C, RVU18D, RVU19A, RVU19B, RVU19C, RVU19D, RVU20A, RVU20B, RVU20C, RVU20D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $45.02 | Not available in this setting | RVU26D |
| 2026-07-01 | $45.02 | Not available in this setting | RVU26C |
| 2026-04-01 | $45.02 | Not available in this setting | RVU26B |
| 2026-01-01 | $45.02 | Not available in this setting | RVU26A |
| 2025-10-01 | $45.44 | Not available in this setting | RVU25D |
| 2025-07-01 | $45.44 | Not available in this setting | RVU25C |
| 2025-04-01 | $45.44 | Not available in this setting | RVU25B |
| 2025-01-01 | $45.44 | Not available in this setting | RVU25A |
| 2024-10-01 | $46.91 | Not available in this setting | RVU24D |
| 2024-07-01 | $46.91 | Not available in this setting | RVU24C |
| 2024-04-01 | $46.91 | Not available in this setting | RVU24B |
| 2024-03-09 | $46.91 | Not available in this setting | RVU24AR |
| 2024-01-01 | $46.15 | Not available in this setting | RVU24A |
| 2023-10-01 | $47.69 | Not available in this setting | RVU23D |
| 2023-07-01 | $47.69 | Not available in this setting | RVU23C |
| 2023-04-01 | $47.69 | Not available in this setting | RVU23B |
| 2023-01-01 | $47.69 | Not available in this setting | RVU23A |
| 2022-10-01 | $46.73 | Not available in this setting | RVU22D |
| 2022-07-01 | $46.73 | Not available in this setting | RVU22C |
| 2022-04-01 | $46.73 | Not available in this setting | RVU22B |
| 2022-01-01 | $46.73 | Not available in this setting | RVU22A |
| 2021-10-01 | $47.12 | Not available in this setting | RVU21D |
| 2021-07-01 | $47.12 | Not available in this setting | RVU21C |
| 2021-04-01 | $47.12 | Not available in this setting | RVU21B |
| 2021-01-01 | $47.12 | Not available in this setting | RVU21A |
| 2020-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU20D |
| 2020-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU20C |
| 2020-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU20B |
| 2020-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU20A |
| 2019-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU19D |
| 2019-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU19C |
| 2019-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU19B |
| 2019-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU19A |
| 2018-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU18D |
| 2018-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU18C |
| 2018-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU18B |
| 2018-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU18AR1 |
| 2017-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU17D |
| 2017-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU17C |
| 2017-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU17B |
| 2017-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU17A |
| 2016-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU16D |
| 2016-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU16C |
| 2016-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU16B |
| 2016-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU16A |
| 2015-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU15D |
| 2015-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU15C |
| 2015-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU15B |
| 2015-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU15A |
| 2014-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU14D |
| 2014-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU14C |
| 2014-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU14B |
| 2014-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU14A |
| 2013-10-01 | No unmodified rate in this release | No unmodified rate in this release | RVU13D |
| 2013-07-01 | No unmodified rate in this release | No unmodified rate in this release | RVU13C |
| 2013-04-01 | No unmodified rate in this release | No unmodified rate in this release | RVU13B |
| 2013-01-01 | No unmodified rate in this release | No unmodified rate in this release | RVU13AR |
Where the Iowa rate applies
Iowa is a Medicare payment area, not a city. Our Census mapping connects it to 1026 cities and communities in Iowa. Some span more than one payment area; confirm with the service ZIP.
- Ackley
- Ackworth
- Adair
- Adel
- Afton
- Agency
- Ainsworth
- Akron
G0452 billing questions
When should G0452 be reported instead of the molecular assay code?
G0452 represents the physician’s interpretation and report, not the laboratory procedure that generates the molecular results. Report the applicable assay code for the testing itself.
How do modifiers 26 and TC affect G0452?
Modifier 26 reports the professional interpretation, while modifier TC reports the technical work, including equipment and staff. Without a modifier, G0452 represents the global service.
What documentation supports G0452?
Document the molecular test results reviewed and the physician’s interpretation and report. The record should make clear that the reported service includes interpretive work, not only test performance.
Can G0452 be reported with a molecular assay code?
Yes, the interpretation may be reported with the applicable molecular assay code when both the test and the physician’s interpretive service are furnished and documented.
Does G0452 describe a particular gene panel or specimen?
No. G0452 identifies the interpretation and report service; the assay code identifies the specific molecular test and its scope.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
Fee sheets · Coming soon
Put G0452 and the rest of your codes on one sheet
Your codes at your locality, with payer contracts beside Medicare.
Join the waitlist