HCPCS code G0452: Molecular interpretation, physician interpretation and report2026 Medicare rate & RVUs

Medicare pays $46.76 for G0452 nationally in the office. Local office rates run $44.22–$62.68.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What G0452 covers

A physician reviews results from a molecular pathology assay and prepares an interpretation and report. The testing may analyze DNA or RNA from sources such as tumor tissue or blood to identify molecular findings relevant to diagnosis or treatment. A pathologist or another qualified physician may provide this service in a hospital, reference laboratory, or other setting where molecular diagnostic testing is performed.

Report G0452 for the physician’s interpretive service when supported by the work documented; the assay itself is represented by its applicable test code. CMS recognizes professional and technical components: modifier 26 identifies the interpretation, and modifier TC identifies the technical work, including equipment and staff. Without either modifier, the claim represents the global service. Documentation should identify the test results reviewed and include the physician’s interpretive findings and report. CMS lists modifiers 26 and TC as separately priced.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where G0452 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

G0452 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the G0452 rate is calculated

Each of G0452’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for G0452

The CMS indicators that decide how G0452 is paid alongside other services.

What modifiers do to the payment

When to use modifier 26

G0452 compared with similar codes

How to choose

81455Tumor genomic panel51+ genes, DNA or DNA/RNA

81455 identifies a targeted genomic sequencing panel for specified neoplasm types; G0452 reports the physician’s interpretation and report of molecular results.

81479Molecular pathologyUnlisted procedure

81479 represents an unlisted molecular pathology procedure when the assay lacks a specific code. G0452 represents interpretive work, not the assay procedure.

81450Hematolymphoid panel5–50 genes, DNA or combined

81450 identifies genomic sequencing for hematolymphoid neoplasms. G0452 describes the physician’s interpretation and report rather than the sequencing assay.

Codes related to G0452

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates