HCPCS code J0643: Leucovorin injection, per 1 mg2026 Medicare rate & RVUs in Illinois
Injectable leucovorin calcium is reported in 1 mg units for methotrexate rescue or as part of certain fluorouracil cancer regimens.
CMS doesn’t publish an office rate for J0643 in Illinois.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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What J0643 covers
J0643 identifies injectable leucovorin calcium not otherwise specified. Leucovorin is used as rescue after high-dose methotrexate and alongside fluorouracil in cancer treatment. Oncology clinicians administer it by injection, commonly in outpatient oncology offices and infusion centers. Choose the appropriate leucovorin code for the product supplied; J0643 is the not-otherwise-specified option.
One unit represents 1 mg of leucovorin calcium, so reported units match the administered milligram dose. CMS assigns physician fee schedule status E, excluding J0643 from the physician fee schedule by regulation. When Medicare covers the drug, payment is under another method; as a Part B drug, it is generally priced using CMS quarterly Average Sales Price drug pricing files. Special Medicare coverage instructions apply.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where J0643 pays more and less in Illinois
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
| Payment locality | Office | Facility |
|---|---|---|
| Chicago, IL | Unavailable | Unavailable |
| East St. Louis, IL | Unavailable | Unavailable |
| Rest of Illinois | Unavailable | Unavailable |
| Suburban Chicago, IL | Unavailable | Unavailable |
How the J0643 rate is calculated
Each of J0643’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · J0643
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense0.00
0.00 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
0.0000
Conversion factor
$33.4009
Medicare rate
$0.00
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for J0643
J0643 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.
Place of service · J0643
Which rate does Medicare pay?
The POS code on the claim line (CMS-1500 box 24B).
POS 11 · non-facility rate · national
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J0643 isn’t priced in this setting.
J0643 compared with similar codes
Compare codes · National
5 codes, side by side
How to choose
- J0640Leucovorin injectionPer 50 mg
- J0640 also describes leucovorin calcium injection. J0643 specifies a 1 mg unit; choose according to the applicable product code and descriptor.
- J0644Avyxa leucovorinPer 1 mg
- J0644 identifies leucovorin calcium as the Avyxa product. J0643 is the not-otherwise-specified leucovorin calcium code.
- J0641Levoleucovorin injectionPer 0.5 mg
- J0641 is for levoleucovorin, not leucovorin calcium, and its billing unit is 0.5 mg.
- J0642Levoleucovorin injectionKhapzory, per 0.5 mg
- J0642 identifies the Khapzory levoleucovorin product in 0.5 mg units; J0643 identifies leucovorin calcium in 1 mg units.
J0643 billing questions
What does one J0643 unit represent?
One unit represents 1 mg of leucovorin calcium. Report units to match the administered dose in milligrams.
How is J0643 different from J0640?
Both codes identify leucovorin calcium injection. J0643 specifies a 1 mg unit; select the code that matches the product and applicable HCPCS descriptor.
When should J0643 be distinguished from J0644?
J0643 is the not-otherwise-specified leucovorin calcium code. J0644 identifies the Avyxa product.
Is J0643 the code for levoleucovorin?
No. J0643 is for leucovorin calcium. J0641 and J0642 identify levoleucovorin products.
How does Medicare treat J0643?
Its physician fee schedule status is E, so it is excluded from the physician fee schedule. When covered, it is paid under another method; as a Part B drug, it is generally priced using CMS quarterly ASP drug pricing files. Special Medicare coverage instructions apply.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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