HCPCS code J0644: Avyxa leucovorin, per 1 mg2026 Medicare rate & RVUs

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What J0644 covers

J0644 identifies Avyxa, an injectable leucovorin calcium product. Leucovorin is used to lessen the toxic effects of high-dose methotrexate and, in certain cancer regimens, alongside fluorouracil. Oncology practices and hospital outpatient departments may report the drug when it is administered by injection, typically intravenously; it may also be given intramuscularly. The drug code identifies the medication, not the administration service.

CMS assigns this code physician fee schedule status E, meaning it is excluded from the physician fee schedule. When Medicare covers the drug, it generally pays it as a Part B drug using CMS's quarterly Average Sales Price drug pricing files. Coverage is left to the Medicare contractor's judgment. Each unit represents 1 mg of leucovorin calcium: a 25 mg administered dose corresponds to 25 units. Report the Avyxa-specific code for that product rather than another leucovorin calcium code.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where J0644 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

J0644 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the J0644 rate is calculated

Each of J0644’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for J0644

J0644 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.

J0644 compared with similar codes

How to choose

J0643Leucovorin injectionPer 1 mg

Both describe injectable leucovorin calcium at a 1 mg unit level, but J0644 identifies Avyxa; J0643 does not name that product.

J0640Leucovorin injectionPer 50 mg

J0640 also represents leucovorin calcium injection but uses a different unit measure. Select the code whose product and unit basis match the drug administered.

J0641Levoleucovorin injectionPer 0.5 mg

J0641 identifies levoleucovorin, a different folate drug, rather than leucovorin calcium. Do not choose it for Avyxa.

J0642Levoleucovorin injectionKhapzory, per 0.5 mg

J0642 identifies Khapzory, a levoleucovorin product. J0644 is for Avyxa leucovorin calcium.

Codes related to J0644

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates