HCPCS code J0644: Avyxa leucovorin, per 1 mg2026 Medicare rate & RVUs in Texas
Reports injectable Avyxa leucovorin calcium by each milligram administered, commonly for methotrexate rescue or with fluorouracil in oncology care.
CMS doesn’t publish an office rate for J0644 in Texas.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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What J0644 covers
J0644 identifies Avyxa, an injectable leucovorin calcium product. Leucovorin is used to lessen the toxic effects of high-dose methotrexate and, in certain cancer regimens, alongside fluorouracil. Oncology practices and hospital outpatient departments may report the drug when it is administered by injection, typically intravenously; it may also be given intramuscularly. The drug code identifies the medication, not the administration service.
CMS assigns this code physician fee schedule status E, meaning it is excluded from the physician fee schedule. When Medicare covers the drug, it generally pays it as a Part B drug using CMS's quarterly Average Sales Price drug pricing files. Coverage is left to the Medicare contractor's judgment. Each unit represents 1 mg of leucovorin calcium: a 25 mg administered dose corresponds to 25 units. Report the Avyxa-specific code for that product rather than another leucovorin calcium code.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where J0644 pays more and less in Texas
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
8 of 8 payment localities
| Payment locality | Office | Facility |
|---|---|---|
| Austin, TX | Unavailable | Unavailable |
| Beaumont, TX | Unavailable | Unavailable |
| Brazoria, TX | Unavailable | Unavailable |
| Dallas, TX | Unavailable | Unavailable |
| Fort Worth, TX | Unavailable | Unavailable |
| Galveston, TX | Unavailable | Unavailable |
| Houston, TX | Unavailable | Unavailable |
| Rest of Texas | Unavailable | Unavailable |
How the J0644 rate is calculated
Each of J0644’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · J0644
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense0.00
0.00 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
0.0000
Conversion factor
$33.4009
Medicare rate
$0.00
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for J0644
J0644 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.
Place of service · J0644
Which rate does Medicare pay?
The POS code on the claim line (CMS-1500 box 24B).
POS 11 · non-facility rate · national
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J0644 isn’t priced in this setting.
J0644 compared with similar codes
Compare codes · National
5 codes, side by side
How to choose
- J0643Leucovorin injectionPer 1 mg
- Both describe injectable leucovorin calcium at a 1 mg unit level, but J0644 identifies Avyxa; J0643 does not name that product.
- J0640Leucovorin injectionPer 50 mg
- J0640 also represents leucovorin calcium injection but uses a different unit measure. Select the code whose product and unit basis match the drug administered.
- J0641Levoleucovorin injectionPer 0.5 mg
- J0641 identifies levoleucovorin, a different folate drug, rather than leucovorin calcium. Do not choose it for Avyxa.
- J0642Levoleucovorin injectionKhapzory, per 0.5 mg
- J0642 identifies Khapzory, a levoleucovorin product. J0644 is for Avyxa leucovorin calcium.
J0644 billing questions
When should a biller choose J0644 instead of J0643?
Use J0644 for Avyxa. J0643 describes leucovorin calcium at a 1 mg unit level but does not name Avyxa.
How many units should be reported?
Each unit represents 1 mg of leucovorin calcium. A 25 mg dose corresponds to 25 units.
Does J0644 report the injection administration?
No. J0644 identifies the Avyxa drug, not the service of administering it.
How does Medicare treat J0644?
CMS excludes it from the physician fee schedule (status E). When covered, it is generally paid as a Part B drug using the quarterly ASP drug pricing files, and the Medicare contractor determines coverage.
Is J0644 used for oral leucovorin?
No. J0644 identifies injectable Avyxa leucovorin calcium, not an oral product.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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