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HCPCS Q4227: AmniocoreMedicare rate & RVUs

Report Amniocore per square centimeter when this amniotic membrane product is applied with a primary wound procedure, such as treatment of an ulcer.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare pays $127.26 for Q4227 nationally in the office. Local office rates run $109.31–$183.51.

Medicare rate · Q4227

Amniocore

Work RVUs
0
Total RVUs
3.81
Global days
ZZZ

National rate · 2026

$127.26

Office setting, before claim adjustments.

See every locality for Q4227 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

On this page 10 sections
  1. Medicare rate
  2. What Q4227 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q4227 covers

Amniocore is an amniotic membrane product reported by the square centimeter when used as part of wound treatment. Wound care clinicians and surgeons may apply it to a prepared wound in an outpatient clinic, hospital department, or surgical setting. Examples include chronic ulcers and surgical wounds; the product supply is distinct from the procedure that prepares and treats the wound.

Report Q4227 with the primary procedure that applies the product, using the quantity of Amniocore applied. Documentation should identify the product, wound site, treated area, and quantity so the reported units can be supported. CMS classifies this as an add-on code paid within the primary procedure’s global period. It is technical-component-only; a separate code covers interpretation. Its CMS relative-value profile assigns practice expense and no physician work RVU.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4227 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 payment localities

$109.31 to $183.51

$109.31$146.41$183.51
One dot per payment locality, office / nonfacility. Hover a dot to see the locality; select it to open that rate.

109 of 109 payment localities

Q4227 office and facility rates by payment locality
Payment localityOfficeFacility
Alabama$111.35Unavailable
Alaska*$135.53Unavailable
Arizona$123.31Unavailable
Arkansas$109.31Unavailable
Atlanta$129.29Unavailable
Austin$134.64Unavailable
Bakersfield$139.47Unavailable
Baltimore/Surr. Cntys$136.55Unavailable
Beaumont$115.80Unavailable
Brazoria$126.11Unavailable

Q4227 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
Q4227 office rate range by state
State / territoryOffice rate rangeLocalities
AK$135.531
AL$111.351
AR$109.311
AZ$123.311
CA$139.47–$183.5129
CO$135.401
CT$137.061
DC$149.911
DE$125.731
FL$121.66–$132.473
GA$113.51–$129.292
GU$144.691
HI$144.691
IA$116.441
ID$117.081
IL$116.19–$130.694
IN$117.971
KS$115.041
KY$113.131
LA$112.62–$119.752
MA$134.00–$151.952
MD$128.78–$149.913
ME$117.08–$126.112
MI$116.19–$122.802
MN$130.951
MO$109.70–$121.153
MS$109.571
MT$127.261
NC$118.731
ND$127.261
NE$117.461
NH$132.471
NJ$138.97–$147.622
NM$116.701
NV$127.381
NY$120.89–$151.315
OH$116.191
OK$113.641
OR$126.75–$141.382
PA$116.82–$132.472
PR$128.661
RI$131.461
SC$117.591
SD$127.261
TN$115.681
TX$115.80–$134.648
UT$119.621
VA$125.09–$149.912
VI$128.661
VT$125.981
WA$134.00–$156.142
WI$121.911
WV$110.591
WY$127.261

How the Q4227 rate is calculated

Each of Q4227’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q4227

RVUs × geographic indexes × conversion factor

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense3.81

3.81 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

3.8100

Conversion factor

$33.4009

Medicare rate

$127.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q4227

The CMS indicators that decide how Q4227 is paid alongside other services.

CMS payment indicators · Q4227

Amniocore

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical3Technical component only.

Q4227 compared with similar codes

Compare codes · National

4 codes, side by side

  • Q4227

    Amniocore0 wRVU

    $127.26

  • Q4221

    Wound product0 wRVU

    $127.26+$0.00

  • Q4229

    Amniotic membrane0 wRVU

    $127.26+$0.00

  • Q4226

    Not on the physician fee schedule0 wRVU

    Not priced

How to choose

Q4221Wound product
Q4221 identifies AmnioWrap2; Q4227 identifies Amniocore. Select the code matching the product used, not simply the wound area.
Q4229Amniotic membrane
Q4229 identifies Cogenex amniotic membrane, while Q4227 identifies Amniocore. The product name determines which supply code applies.
Q4226Myown harv prep proc sq cm
Q4226 describes the MyOwn harvest and preparation process. Q4227 reports Amniocore product by square centimeter.

Codes related to Q4227

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q4227
CodeHow it relatesNational office range
Primary code
15271Skin substitute graftPrimary skin-substitute application procedure for eligible trunk, arm, or leg wound areas.$140.17–$205.27
15272Skin substitute graftAdditional-area skin-substitute application procedure when the applicable wound area requires it.$23.02–$32.02
Used instead
Q4221Wound productAmnioWrap2 is another amniotic wound product reported by square centimeter.$109.31–$183.51
Q4229Amniotic membraneCogenex amniotic membrane is another per-square-centimeter wound product.$109.31–$183.51
Q4226Myown harv prep proc sq cmMyOwn describes a harvest and preparation process rather than Amniocore product supply.No office rate

Q4227 billing questions

Can Q4227 be reported by itself?

No. CMS identifies Q4227 as an add-on code that must be billed with a primary procedure.

How is the quantity reported?

The descriptor is per square centimeter. Document the Amniocore quantity applied and the treated wound area to support the reported units.

Does Q4227 include interpretation?

No. It is a technical-component-only code, and a separate code covers interpretation.

What documentation supports Q4227?

Record the Amniocore product, wound site, treated area, quantity applied, and the primary procedure performed.

How does the global period affect payment?

CMS pays Q4227 within the global period of the primary procedure; it is not a stand-alone procedure code.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for Q4227PPRRVU2026_Oct_nonQPP.csv, line 18,318 (RVU26D)

Open CMS sourceHow we calculate rates

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